scholarly journals Prevention of encrustation and biofilm formation on the ureteral stent surface. Part 1

2020 ◽  
Vol 12 (3) ◽  
pp. 176-181
Author(s):  
A.Yu. Tsukanov ◽  
◽  
D.S. Akhmetov ◽  
A.A. Novikov ◽  
D.A. Negrov ◽  
...  
Urologiia ◽  
2018 ◽  
Vol 2_2018 ◽  
pp. 40-45
Author(s):  
A.Yu. Tsukanov Tsukanov ◽  
D.S. Akhmetov Akhmetov ◽  
A.I. Blesman Blesman ◽  
E.A. Rogachev Rogachev ◽  
◽  
...  

Pathogens ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 764
Author(s):  
Kymora B Scotland ◽  
Sonia HY Kung ◽  
Ben H Chew ◽  
Dirk Lange

Despite routine implementation in urology, indwelling ureteral stents pose as a nidus for infection. Conditioning film accumulates on stents, which prime pathogen adhesion, promoting infectious biofilm formation. However, the extent to which conditioning film components play a role in facilitating bacterial adhesion and biofilm formation remains largely unknown. Here, we examined the interaction of previously identified stent-bound conditioning film components (fibrinogen, uromodulin, and albumin) with bacterial uropathogens. Cytoscopically removed stents were incubated with common uropathogens (Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus). Immunofluorescent double staining was performed to study the localization of uropathogens relative to stent-bound conditioning film proteins. Conditioning film components were identified on the external stent surface with some deposition in the inner lumen. Bacteria co-localized with fibrinogen, uromodulin, and albumin, suggesting a potential mechanism for stent-associated infections. Here, we determine strong co-localization between common uropathogenic bacterial species with prominent conditioning film components on ureteral stents. Further functional validation of interactions amongst these uropathogens and conditioning film proteins may enhance clinical management for stent-associated infections and development of improved stent technologies.


2007 ◽  
Vol 51 (12) ◽  
pp. 4518-4520 ◽  
Author(s):  
Oscar Cirioni ◽  
Roberto Ghiselli ◽  
Daniele Minardi ◽  
Fiorenza Orlando ◽  
Federico Mocchegiani ◽  
...  

ABSTRACT Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.


2020 ◽  
Vol 13 (4) ◽  
pp. 132-138
Author(s):  
A.Yu. Tsukanov ◽  
◽  
D.S. Akhmetov ◽  
A.A. Novikov ◽  
D.A. Negrov ◽  
...  

Introduction. Stent encrustation and formation of biofilms on its surfaces are serious medical problems, that cannot be solved without removing or replacing of the drain. Various researches are being conducted worldwide, trying to solve this problem, while a universal way of such stent complications prevention is still unreached. Aim. The aim of this study was to evaluate the effectiveness of biodegradable stents and physical methods as alternative ways to prevent drainage complications. Materials and methods. A literature search was performed of the Pubmed, Web of Sience, Science Direct, Scopus, Cyberleninka, E-library, CNMB and other databases for the period of time from 1984 to 2020 for the following keywords: ureteral stent, encrustation, biofilm, urolithiasis, bacteriuria, ultrasound. Of more than 100 studies found, 48 scientific papers, most fully correspond to the article topic, were analyzed. Results. The use of biodegradable stents eliminates a need for interventions to remove them, improving the patient's quality of life, as well as reducing the economic burden on the healthcare system. However, the problem of degradation rate control and stent degradation products elimination still exists. Conclusions. The majority of proposed physical methods of impact on a stent need a contact way of implementation, that largely hinders their clinical use. Thus, non-invasive methods seem promising and require further researches.


Author(s):  
B.D. Tall ◽  
K.S. George ◽  
R. T. Gray ◽  
H.N. Williams

Studies of bacterial behavior in many environments have shown that most organisms attach to surfaces, forming communities of microcolonies called biofilms. In contaminated medical devices, biofilms may serve both as reservoirs and as inocula for the initiation of infections. Recently, there has been much concern about the potential of dental units to transmit infections. Because the mechanisms of biofilm formation are ill-defined, we investigated the behavior and formation of a biofilm associated with tubing leading to the water syringe of a dental unit over a period of 1 month.


2006 ◽  
Vol 175 (4S) ◽  
pp. 18-18
Author(s):  
Kari Hendlin ◽  
Krishna Vedula ◽  
Christina Horn ◽  
Manoj Monga

2004 ◽  
Vol 171 (4S) ◽  
pp. 128-128
Author(s):  
Martti Talja ◽  
Juha Lumiaho ◽  
Antero Heino ◽  
Tero Valimaa ◽  
Pertti Tormala
Keyword(s):  

1990 ◽  
Vol 26 (5) ◽  
pp. 871
Author(s):  
Y Yoon ◽  
D W Sung ◽  
W S Choi ◽  
D H Lee ◽  
Y T Ko ◽  
...  

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