Association of maternal and umbilical cord blood leptin concentrations and abnormal color Doppler indices of umbilical artery with fetal growth restriction

Overproduction of reactive oxygen species (ROS) and, as a result, uncontrolled oxidative stress (OS) can play a central role in disorders of fetal hemodynamics and subsequent development of adverse perinatal outcomes in newborns with fetal growth restriction (FGR). Given the epigenetic nature of such disorders, the aim of our study was to evaluate the expression of miRNAs associated with OS and endothelial dysfunction (miR-27a-3p, miR-30b-5p, miR-125b-5p, miR-221-3p, miR-451a and miR-574-3p) in umbilical cord blood using real-time quantitative RT-PCR. ΜiRNA expression was evaluated in patients with FGR delivery before (n = 9 pregnant) and after 34 weeks of gestation (n = 13 pregnant), and the control groups corresponding to the main groups by gestational age (13 pregnant women in each group, respectively). A significant increase in miR-451a expression was detected in late-onset FGR and correlations with fetoplacental and cerebral circulation were established (increase of resistance in the umbilical artery (pulsatility index, PI UA (umbilical artery): r = −0.59, p = 0.001) and a decrease in cerebral blood flow (CPR: r = 0.48, p = 0.009)). The change in miR-125b-5p expression in the placenta is associated with reduced Doppler of cerebral hemodynamics (CPR: r = 0.73, p = 0.003; PI MCA (middle cerebral artery): r = 0.79, p = 0.0007), and newborn weight (r = 0.56, p = 0.04) in early-onset FGR. In addition, significant changes in miR-125b-5p and miR-451a expression in umbilical cord blood plasma were found in newborns with neonatal respiratory distress syndrome (NRDS) (in early-onset FGR) and very low birth weight (VLBW) (in late-onset FGR). A number of key signaling pathways have been identified in which the regulation of the studied miRNAs is involved, including angiogenesis, neurotrophin signaling pathway and oxidative stress response. In general, our study showed that changes of the redox homeostasis in the mother-placenta-fetus system in FGR and subsequent perinatal outcomes may be due to differential expression of oxidative stress-associated miRNAs.

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OC12.05: Umbilical artery Doppler indices and ultrasonographic placental biometry in relation to pregnancy outcome in a paradigm of fetal growth restriction

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.9160 ◽

2011 ◽

Vol 38 (S1) ◽

pp. 23-23

Author(s):

D. J. Carr ◽

R. P. Aitken ◽

J. S. Milne ◽

A. L. David ◽

J. M. Wallace

Keyword(s):

Pregnancy Outcome ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Umbilical Artery ◽

Growth Restriction ◽

Umbilical Artery Doppler ◽

Doppler Indices

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Solcoseryl versus Low Molecular Weighte Heparin for Intrauterine Fetal Growth Restriction

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1931097 ◽

2021 ◽

pp. 215-228

Author(s):

Samar M. Abd El-Razek ◽

Mohammed M. Elnamory ◽

Mona K. Omar ◽

Hesham M. Eltokhy

Keyword(s):

Birth Weight ◽

Fetal Growth ◽

Gestational Age ◽

Fetal Growth Restriction ◽

Umbilical Artery ◽

Growth Restriction ◽

Once Daily ◽

Group A ◽

Group B ◽

Doppler Indices

Background: FETAL Growth Restriction (FGR) is a problem where the fetus fails to attain its normal growth potential and this affects nearly about 8% of all pregnancies Solcoseryl is a protein-free and antigen-free haemodialysate derived from calf blood. It is thought to activate the cellular respiratory chain leading to better oxygen utilisation by the tissues. Aim of the study was to compare between Solcoseryl and low molecular weight heparin in treatment of patients suffered from intrauterine growth restriction due to placental insufficiency. Methods: The patients who included in this study were divided randomly via (computer-generated random numeric tables prepared by a statistician) into two groups with 35 cases in each group. Group (A) (Solcoseryl. Group): 35 women received Solcoseryl ampule 42.5 mg intravenous infusion (Misr Compony) Once daily for 3 weeks. Group (B) (LMWH (Clexan) Group): 35 women received single dose of LMWH subcutaneous (clexane 40 mg) once daily for 3 weeks. Results: There is a significant decrease regarding umbilical artery RI in both groups but the significant decrease was better in group A compared to group B. Otherwise, there is no significant difference between the two groups umbilical artery RI at different time intervals. there is significant increase in Gestational age and birth weight in patients who receive solcoseryl and LMWH .There is an improvement in Doppler indices of both (UA and MCA) in both group but is better in solcoseryl than LMWH and significant increase in Apgar score at 1min and 5 min in both groups but is better in solcoseryl than LMWH. Conclusions: In this study, LMWH and Solcoseryl administration in IUGR fetuses enhance Doppler indices, promote significant increase in Gestational age so enhance neonatal birth weight.

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