scholarly journals The Effects of Iron Oxide Nanoparticles Administration on Depression Symptoms Induced by LPS in Male Wistar Rats

2018 ◽  
Vol 9 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Fatemeh Saeidienik ◽  
Mohammad Reza Shahraki ◽  
Hamed Fanaei ◽  
Fereshteh Badini ◽  
◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Wistar Rats ◽  
Depression Symptoms ◽  
Oxide Nanoparticles ◽  
Male Wistar Rats

Genotoxicity assessment of iron oxide nanoparticles in male Wistar rats after chronic oral treatment

2014 ◽  
Vol 229 ◽  
pp. S197 ◽  
Author(s):  
Ruzica Rozgaj ◽  
Vilena Kasuba ◽  
Marin Mladinic ◽  
Nevenka Kopjar ◽  
Vedran Micek ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Wistar Rats ◽  
Oral Treatment ◽  
Oxide Nanoparticles ◽  
Male Wistar Rats

Hepatotoxic and Neurotoxic Potential of Iron Oxide Nanoparticles in Wistar Rats: a Biochemical and Ultrastructural Study

2021 ◽  
Author(s):  
Mostafa Mabrouk ◽  
Ghadha Ibrahim Fouad ◽  
Sara A. M. El-Sayed ◽  
Maha Z. Rizk ◽  
Hanan H. Beherei
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Ultrastructural Study ◽  
Wistar Rats ◽  
Oxide Nanoparticles

Neurotoxicity of green- synthesized magnetic iron oxide nanoparticles in different brain areas of wistar rats

2020 ◽  
Vol 77 ◽  
pp. 80-93 ◽  
Author(s):  
Heba M. Fahmy ◽  
Esraa M. Aly ◽  
Faten F. Mohamed ◽  
Neveen A. Noor ◽  
Anwar A. Elsayed
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Wistar Rats ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Brain Areas ◽  
Magnetic Iron Oxide

Intraperitoneal exposure of iron oxide nanoparticles causes dose-dependent toxicity in Wistar rats

2021 ◽  
pp. 074823372110586
Author(s):  
Gajraj S Verma ◽  
Naresh K Nirmal ◽  
Deepika Gunpal ◽  
Hemant Gupta ◽  
Monika Yadav ◽  
...  
Keyword(s):  
Body Weight ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Wistar Rats ◽  
Serum Lactate Dehydrogenase ◽  
Oxide Nanoparticles ◽  
Mean Corpuscular Hemoglobin ◽  
Dependent Manner ◽  
Corpuscular Hemoglobin ◽  
Control Serum

Nanoparticles of iron oxide, with diameters beteween 1 to 100 nm, have notable implications for human health and well being. In the current study, we have investigated the effects of iron oxide nanoparticles (IONP) exposure on general physiology and health of adult Wistar rats. IONP used in the study had spherical shape and average size in the range of 15–20 nm. A total of eight groups of rats were repeatedly injected with 0 (control), 20, 40, and 80 mg IONP per kg body weight intraperitoneally under two different exposure schemes (sub-acute and sub-chronic). IONP exposure caused significant changes in lungs, liver, and kidney indices in both exposure schemes. Sub-acute exposure did not affect body weight gain in treated rats, but longer duration exposure was responsible for significant reduction in body weight. Mesenteries, visceral fatty tissues, and visceral peritoneal membranes demonstrated apparent accumulations of IONP in a dose and time-dependent manner. Hematological analysis showed that total RBC count, hemoglobin content, hematocrit, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and mean platelet volume (MPV) were not affected by IONP exposure. Total lymphocyte count, however, was elevated in low- and mid-dose treated rats, but not in high-dose group. Serum lactate dehydrogenase (LDH) increased significantly in rats treated with mid and high doses as compared to control. Serum creatinine and blood urea nitrogen levels were also significantly altered in treated rats. Histological study found significant hepatic damage and mild spleen toxicity. Our report suggests that IONP exhibit significant toxicity in rats.

Biochemical alterations induced by acute oral doses of iron oxide nanoparticles in Wistar rats

2012 ◽  
Vol 36 (3) ◽  
pp. 296-305 ◽  
Author(s):  
Monika Kumari ◽  
Sheik Rajak ◽  
Shailendra P. Singh ◽  
Upadhyayula S. N. Murty ◽  
Mohammed Mahboob ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Wistar Rats ◽  
Oxide Nanoparticles ◽  
Biochemical Alterations ◽  
Oral Doses

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Sign in / Sign up

Export Citation Format

Share Document