CORONARY ARTERY DISEASE

Objectives: This study was designed to evaluate the pattern of clinical presentation, risk factors and angiographic findingsin young males presenting with acute myocardial infarction (AMI).Materials and methodsThis cross-sectional descriptive study wasconducted at the Cardiology Department, Punjab Institute of Cardiology, Lahore from May 2005 till February 2006. After fulfilling the inclusioncriteria 200 male patients <40 years with coronary artery disease (CAD) were studied. Results: Mean age of the study population was31.5±9.2 years with an age range of 31 to 40 years. Most common risk factor was smoking present in 60% patients. Family history ofischemic heart disease (IHD) was present in 44.5% patients, hyperlipidemia in 35.5% patients, hypertension in 25.5% and diabetes mellitusin 17.5% of patients.Common mode of clinical presentation was AMI 42.5% patients. Left anterior descending (LAD) was diseased in 73.5%,followed by Left Circumflex (LCx) 51% and Right Coronary Artery (RCA) in 39% patients. Left Main Stem (LMS) disease occurred in 9.5%patients. Good left ventricular (LV) systolic function was observed in 38%, moderate LV systolic function in 34% and poor LV systolic functionin 14.5% patients. Conclusion: Patients with premature coronary artery disease have unheralded acute onset of symptoms. Smoking isthe most common risk factor. Young patients have single vessel CAD with frequent involvement of LAD and commonly have good leftventricular systolic function.

Download Full-text

Familial Hypercholesterolaemia With Premature Coronary Artery Disease: A Case Report

Indian Journal of Clinical Cardiology ◽

10.1177/2632463620943022 ◽

2020 ◽

Vol 1 (3-4) ◽

pp. 150-153

Author(s):

Chandramukhi Sunehra ◽

Krishnaswamy Raghu

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Systolic Function ◽

Color Doppler ◽

Artery Bypass ◽

Density Lipoprotein ◽

Left Ventricular ◽

Lipid Lowering ◽

Premature Coronary Artery Disease ◽

Artery Disease

A young, 18-year-old lady presented with history of chest pain on exertion typical of angina. General examination revealed multiple tendon xanthomas. Systemic examination was unremarkable. Electrocardiogram showed segment (ST) depression in inferior and lateral leads. Echocardiogram revealed normal left ventricular systolic function and no left ventricular regional wall motion abnormalities. Diastolic flow turbulence was noted in the left main coronary artery and proximal left anterior descending artery on color Doppler interrogation across the coronary arteries. Lipid profile showed unusually high total cholesterol and low-density lipoprotein cholesterol. Subsequent evaluation with coronary angiogram revealed triple vessel coronary artery disease. The patient underwent coronary artery bypass surgery and is on antiplatelet and lipid-lowering drug therapy.

Download Full-text

Evaluation of Cardiac Scan in Diagnosing Coronary-artery Disease

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405616666200530211415 ◽

2020 ◽

Vol 16 (8) ◽

pp. 1022-1028

Author(s):

Zubaida Butaish ◽

Masheal Alajmi ◽

Arouba Elahi ◽

Saeed M. Bafaraj

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Systolic Function ◽

Imaging Techniques ◽

Cost Effective ◽

Left Ventricular ◽

Diastolic Filling ◽

Study Results ◽

Artery Disease ◽

Lv Systolic Function

Background: With the evaluation of focal epicardial coronary stenosis and non-obstructive atherosclerosis, the cardiac scans play a significant role in diagnosing coronary artery disease (CAD). Moreover, the advancements in the imaging techniques leading to improved risk assessment and timely therapies help in early diagnosis of CAD with greater accuracy. Aims: To evaluate the role of cardiac scan in diagnosing CAD. Methods: Recruited 100 individuals without any history of CAD that refers to the assessment of suspected angina, conducted the prospective study. Electrocardiogram (ECG) findings assisted in the evaluation of left bundle branch blockage, abnormalities of ST-segment, and pathological Q waves. Results: The results depicted negative N.M findings among 38 respondents; whereas, ischemia and myocardial infarctions were diagnosed in 26% and 19% of the respondents, respectively. The majority of the males (59) were positive in contrast to 37 females with positive results. Similarly, 24 respondents were presented with mild dilated left atria (LA), 37 respondents suffered from impaired relaxation pattern of left ventricular (LV) diastolic filling; while, 40 of the respondents had normal global LV systolic function. Conclusion: The study results have concluded that non-invasive, low-risk, and cost-effective technique like ECG is an important beneficial advancement in the diagnosis of CAD.

Download Full-text

Homocysteine, left ventricular dysfunction and coronary artery disease: is there a link?

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2007.353 ◽

2007 ◽

Vol 45 (12) ◽

Cited By ~ 3

Author(s):

Gian Paolo Rossi ◽

Teresa Maria Seccia ◽

Achille Cesare Pessina

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Systolic Function ◽

Left Ventricular ◽

Lv Function ◽

Atherosclerotic Burden ◽

Mechanistic Investigation ◽

Artery Disease ◽

Genetic And Environmental Factors ◽

Lv Systolic Function

AbstractExperimental and observational studies support a role of plasma homocysteine levels (tHcy) in coronary artery disease (CAD). In the GENICA (Genetic and Environmental factors In Coronary Atherosclerosis) study, we found that high tHcy predicted cardiovascular mortality in hypertensive, but not in normotensive, patients independently of CAD and history of myocardial infarction. Moreover, despite not being associated with the coronary atherosclerotic burden, tHcy was inversely associated with left ventricular (LV) ejection fraction. This inverse relationship between LV systolic function and tHcy, which has been independently confirmed, might explain the association of tHcy with the risk of incident heart failure documented in the Framingham Heart Study. Thus, additional mechanistic investigation taking into consideration the effects of tHcy on LV function is necessary to further explore the potential therapeutic usefulness of tHcy lowering treatment in CAD.Clin Chem Lab Med 2007;45:1645–51.

Download Full-text