scholarly journals OVARIAN HYPERSTIMULATION SYNDROME;

2014 ◽  
Vol 21 (03) ◽  
pp. 580-582
Author(s):  
ASMA Batool ◽  
Saima Perveen ◽  
Mussarat Sultana
Keyword(s):  
Abdominal Pain ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Ovarian Hyperstimulation ◽  
Rare Entity ◽  
Ovulatory Cycle ◽  
Successful Management ◽  
Multiple Gestations ◽  
Prompt Diagnosis ◽  
Ovarian Syndrome

It is known that most cases of Ovarian Hyperstimulation Syndrome (OHSS) areassociated with the therapies for ovulation induction. However, OHSS may rarely be associatedwith a spontaneous ovulatory cycle, usually in the case of multiple gestations, hypothyroidism orpolycystic ovarian syndrome. We report a case of moderate OHSS in spontaneously conceivedtwin pregnancy in a 24 years old woman. The clinical picture showed amenorrhea,nausea,vomiting, abdominal pain and moderate ascites. After examinations, imaging and laboratoryinvestigations, the diagnosis was established. The patient was managed expectantly with nocomplications. Although spontaneous ovarian hyperstimulation is a rare entity, it is important thatthe physician recognizes this condition. Prompt diagnosis and successful management is likelyto avoid serious complications, which may develop rapidly.

scholarly journals Prevention of Ovarian Hyperstimulation Syndrome: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Vinayak Smith ◽  
Tiki Osianlis ◽  
Beverley Vollenhoven
Keyword(s):  
Gnrh Agonist ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Best Practice ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Ovarian Hyperstimulation ◽  
Management Options ◽  
Broad Perspective ◽  
Single Method

The following review aims to examine the available evidence to guide best practice in preventing ovarian hyperstimulation syndrome (OHSS). As it stands, there is no single method to completely prevent OHSS. There seems to be a benefit, however, in categorizing women based on their risk of OHSS and individualizing treatments to curtail their chances of developing the syndrome. At present, both Anti-Müllerian Hormone and the antral follicle count seem to be promising in this regard. Both available and upcoming therapies are also reviewed to give a broad perspective to clinicians with regard to management options. At present, we recommend the use of a “step-up” regimen for ovulation induction, adjunct metformin utilization, utilizing a GnRH agonist as an ovulation trigger, and cabergoline usage. A summary of recommendations is also made available for ease of clinical application. In addition, areas for potential research are also identified where relevant.

scholarly journals Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Emsal Pinar Topdagi Yilmaz ◽  
Omer Erkan Yapca ◽  
Yunus Emre Topdagi ◽  
Seray Kaya Topdagi ◽  
Yakup Kumtepe
Keyword(s):  
Gene Mutation ◽  
Ovarian Hyperstimulation Syndrome ◽  
Case Reports ◽  
Receptor Gene ◽  
First Trimester ◽  
Fsh Receptor ◽  
Ovarian Hyperstimulation ◽  
Ovulatory Cycle ◽  
Fshr Gene ◽  
Stimulating Hormone

Development of ovarian hyperstimulation syndrome (OHSS) is very rare in a spontaneous ovulatory cycle and it is usually seen during pregnancy. In the etiology of OHSS, higher hCG (molar pregnancies or multiple pregnancies) and thyroid-stimulating hormone (TSH) levels have been accused. In recent years, some follicle-stimulating hormone (FSH) receptor (FSHR) gene mutations have been described in patients with OHSS in the first trimester with normal hCG levels. Herein, we report two cases of FSHR gene mutation during the investigation of the etiology of spontaneous OHSS. Although OHSS is typically associated with ovulation induction, it should be kept in mind that this condition may also develop in spontaneous pregnancies.

scholarly journals Antral follicle count and anti-Müllerian hormone level as predictors of ovarian hyperstimulation syndrome in women with polycystic ovarian syndrome undergoing controlled ovarian stimulation

2021 ◽  
Vol 21 (86) ◽  
pp. e200-e205
Author(s):  
Rubina Izhar ◽  
◽  
Samia Husain ◽  
Muhammad Ahmad Tahir ◽  
Mauzma Kausar ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Ovarian Stimulation ◽  
Ovarian Hyperstimulation Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Hormone Level ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Controlled Ovarian Stimulation ◽  
Ovarian Hyperstimulation ◽  
Ovarian Syndrome

Aim: To compare the rate of ovarian hyperstimulation syndrome in women with and without polycystic ovarian syndrome, and to determine the cut-off for the antral follicle count and the anti-Müllerian hormone level predictive of ovarian hyperstimulation syndrome in both groups. Methods: This was a prospective cohort study conducted in women aged 20–35 years who were undergoing controlled ovarian stimulation. The women were divided into those with polycystic ovarian syndrome and the controls on the basis of the Rotterdam criteria. The outcome of stimulation was recorded, and the ovarian response markers were compared in both groups. Results: Among 689 women included in the study, 276 (40.1%) had polycystic ovarian syndrome, and 476 (59.9%) were used as the controls. Ovarian hyperstimulation syndrome occurred in 19.6% of the cases, and in 7.7% of the controls (p <0.001). The conception rate was greater in the group of cases (52.5% vs. 16.5%, p = 0.001). Among the cases, the sensitivity and specificity for the prediction of hyper-response were 94.4% and 97.3% for AFC, and 92.6% and 93.7% for the anti-Müllerian hormone, at the cut-off values of ≥18 and ≥6.425 ng/ml, respectively. Among the controls, the sensitivity and specificity for the prediction of hyper-response were 93.8% and 97.1% for the antral follicle count, and 93.6% and 94.5% for the anti-Müllerian hormone, at the cut-off values of ≥10 and ≥3.95 ng/ml, respectively. Conclusion: Group-specific values should be used to identify and counsel women undergoing controlled ovarian stimulation. In light of available evidence, gynaecologists should be trained to perform ultrasound evaluation, determine the antral follicle count of their patients, and offer them appropriate counselling.

Ovarian hyperstimulation syndrome

2016 ◽  
Author(s):  
Stergios K. Doumouchtsis ◽  
S. Arulkumaran ◽  
Kamal Ojha
Keyword(s):  
Vascular Permeability ◽  
Peritoneal Cavity ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Ovarian Hyperstimulation

This chapter outlines ovarian hyperstimulation syndrome (OHSS), the most serious complication of ovulation induction. OHSS is characterized by massive cystic enlargement of the ovaries, an increase in vascular permeability, and a shift of fluid to the extravascular compartments (mainly the peritoneal cavity), with the formation of ascites. The management and prevention of OHSS is described in this chapter.

scholarly journals Reproductive Outcomes of Women with Polycystic Ovarian Syndrome Following In-Vitro Fertilization — A Meta-Analysis and Systematic Review

2019 ◽  
Vol 01 (04) ◽  
pp. 193-201
Author(s):  
I-Ferne Tan ◽  
Audrey J. R. Lim ◽  
Inthrani R. Indran ◽  
Michael S. Kramer ◽  
Eu-Leong Yong
Keyword(s):  
Live Birth ◽  
Ovarian Hyperstimulation Syndrome ◽  
Birth Rate ◽  
Meta Analysis ◽  
Live Birth Rate ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization ◽  
Ivf Outcomes ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is a common cause of infertility in women. In-vitro fertilization (IVF) is required in 20–30% of women with PCOS trying to conceive. This is associated with increased risk of multiple gestation and ovarian hyperstimulation syndrome. Improvements in IVF techniques, safety standards, and the increased use of frozen embryos in recent years have lead to improved outcomes for women with PCOS. We performed a systematic review and meta-analysis to compare these outcomes with women without PCOS. Search Methods: A search of PubMed, EMBASE, the Cochrane Central Register of clinical trials, and Scopus databases for all articles published until November 16th, 2017 identified 21 studies comparing IVF outcomes in PCOS and non-PCOS women. Inclusion criteria were Rotterdam criteria PCOS, comparable IVF regimes, immediate IVF outcomes, and pregnancy outcomes. Studies were excluded if the control group included any PCOS criteria, donor oocytes, or in-vitro maturation. Outcomes: No difference was observed in live birth rate per cycle in women with vs. without PCOS (RR [Formula: see text] 1.01 [0.89, 1.16]; [Formula: see text] 82%), but the live birth rate per first cycle in PCOS cycles (RR [Formula: see text] 0.93 [0.88, 0.99]) was slightly lower. There was also no difference in the clinical pregnancy rate (RR 1.02 [0.89, 1.17]) or biochemical pregnancy rate (RR 1.03 [0.99, 1.08]) observed between the two groups. PCOS was associated with a significantly higher number of oocytes retrieved (mean difference [Formula: see text] 3.6; 95% CI [2.8, 4.4]), risk of miscarriage (RR 2.90 [2.09, 4.02]), and risk of ovarian hyperstimulation syndrome (RR 3.42 [2.28, 5.13]) per cycle. Conclusion: Despite a widespread perception of poor reproductive potential, women with PCOS experience IVF outcomes similar to those without PCOS. Although there is a slightly lower live birth rate during their first stimulation cycle, success rates are similar after multiple cycles. PCOS is associated with a higher risk of ovarian hyperstimulation syndrome. Further studies are required to mitigate this risk.

scholarly journals A Early Development of Severe Ovarian Hyperstimulation Syndrome following Ovulation Induction

JMS SKIMS ◽  
2011 ◽  
Vol 14 (1) ◽  
pp. 30-32
Author(s):  
Fayaz A Sofi ◽  
Wasim Ahmed ◽  
Ghulam Nabi Dhobi ◽  
Showkat Ali Mufti ◽  
Rafi Ahmed Jan ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Capillary Permeability ◽  
Ovarian Hyperstimulation ◽  
Fatal Complication ◽  
Vitro Fertilization ◽  
Severe Ovarian Hyperstimulation Syndrome

Ovarian Hyperstimulation is a rare but potentially fatal complication of ovarian stimulation during treatment of infertility. Worldwide the incidence of this syndrome is increasing due to liberal use of invitro fertilization for management of infertility. The syndrome is characterized by cystic ovarian enlargement and abnormal capillary permeability due to secretion of vasogenic substances by ovaries. The syndrome is classified into early and late variants with early variants usually mild to moderate in severity. We present a case of severe ovarian hyperstimulation syndrome (OHSS) developing early in a 25-year female while undergoing In-vitro fertilization (IVF). Six days after ovulation induction, the woman developed ascites, bilateral pleural effusion and acute renal failure with ultrasound abdomen revealing bilateral cystic enlargement of ovaries. JMS 2011;14(1):30-32

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