Prevalence Comparsion between typhoid fever and H. pylori bacteria in Al-Diwaniyah province

SUMMARYWe evaluated the association between typhoid fever andHelicobacter pyloriinfection, as the latter microorganism may influence gastric acid secretion and consequently increase susceptibility toSalmonella typhiinfection. Anti-H. pyloriIgG and IgA antibody titres (ELISA) and gastrin concentration (RIA) were determined in the plasma of 87 blood culture-confirmed typhoid fever cases (collected after clinical recovery) and 232 random healthy controls without a history of typhoid fever, in the Jatinegara district, Jakarta. Patients with typhoid fever more often than controls were seropositive forH. pyloriIgG (67%vs. 50%,P<0·008), when antibody titres were dichotomized around median titres observed in controls.H. pyloriIgA seropositivity was not associated with typhoid fever. Plasma gastrin concentrations indicative of hypochlorhydria (i.e. gastrin ⩾25 or ⩾100 ng/l) were not significantly elevated in typhoid fever cases compared to controls (P=0·54 andP=0·27 respectively). In a multivariate analysis, typhoid fever was independently associated with young age (<33 years, median age of the controls) [odds ratio (OR) 7·93, 95% confidence interval (CI) 3·90–16·10], andH. pyloriIgG seropositivity (OR 1·93, 95% CI 1·10–3·40). Typhoid fever was independently associated withH. pyloriIgG seropositivity, but not with elevated gastrin concentration. Therefore, the association suggests a common risk of environmental exposure to both bacteria, e.g. poor hygiene, rather than a causal relationship via reduced gastric acid production.

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Prevalence of Typhoid fever and Helicobacter pylori infection in local population of Faisalabad, Pakistan

10.21203/rs.3.rs-1101802/v1 ◽

2021 ◽

Author(s):

Ali Raza Ishaq

Keyword(s):

Social Sciences ◽

Helicobacter Pylori ◽

Gastric Carcinoma ◽

Data Processing ◽

Typhoid Fever ◽

Gastric Acid ◽

Local Population ◽

Age Group ◽

Infected People ◽

H Pylori

Abstract BackgroundTyphoid fever and Helicobacter pylori infection increases the secretion of gastric acid that leads to gastric carcinoma. In this research, we have tried to investigate the prevalence of typhoid and H. pylori in Faisalabad, Pakistan.MethodIn the present study, we collected the laboratory reports from different hospital of Faisalabad, Punjab, Pakistan. Statistical Package for Social Sciences (SPSS) (Chicago, IL), version 25 was used for data processing.ResultOur results demonstrated that H. pylori was most frequent in male at the age of 41–50-year-old and typhoid in female having 21-30 age.ConclusionConclusively, mostly female in typhoid and male in H. pylori were infected. People having 21-30 age were greatly infected by typhoid. The patients owing the 41-50 age were more susceptible for H. pylori infections. By comparing the co-infection rate, we found that typhoid is most common in over all age group than H. pylori.

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Seropositivity of H. pylori and Typhoid Fever in Dyspepsia Iraqi Patients

10.47275/0032-745x-291 ◽

2021 ◽

Vol 107 (1) ◽

Author(s):

Ali Razzaq Hussein ◽

Nawfal H Aldujaili

Keyword(s):

Typhoid Fever ◽

H Pylori

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The rod-to-coccoid body transformation in cultures of Helicobacter pylori

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100160686 ◽

1990 ◽

Vol 48 (3) ◽

pp. 626-627

Author(s):

A. R. Crooker ◽

W. G. Kraft ◽

T. L. Beard ◽

M. C. Myers

Keyword(s):

Helicobacter Pylori ◽

Growth Cycle ◽

Negative Bacterium ◽

Body Formation ◽

Coccoid Form ◽

Spiral Form ◽

Prolonged Culture ◽

H Pylori ◽

Upper Gastrointestinal

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.

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Vacuoles Induced in Mammalian Cells by Helicobacter Cytotoxin are Acidic Organelles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158388 ◽

1990 ◽

Vol 48 (3) ◽

pp. 168-169

Author(s):

M. H. Chestnut ◽

C. E. Catrenich

Keyword(s):

Acridine Orange ◽

Mammalian Cells ◽

Laser Scanning ◽

Laser Scanning Microscopy ◽

Confocal Laser ◽

Ulcer Disease ◽

Gastroduodenal Disease ◽

H Pylori

Helicobacter pylori is a non-invasive, Gram-negative spiral bacterium first identified in 1983, and subsequently implicated in the pathogenesis of gastroduodenal disease including gastritis and peptic ulcer disease. Cytotoxic activity, manifested by intracytoplasmic vacuolation of mammalian cells in vitro, was identified in 55% of H. pylori strains examined. The vacuoles increase in number and size during extended incubation, resulting in vacuolar and cellular degeneration after 24 h to 48 h. Vacuolation of gastric epithelial cells is also observed in vivo during infection by H. pylori. A high molecular weight, heat labile protein is believed to be responsible for vacuolation and to significantly contribute to the development of gastroduodenal disease in humans. The mechanism by which the cytotoxin exerts its effect is unknown, as is the intracellular origin of the vacuolar membrane and contents. Acridine orange is a membrane-permeant weak base that initially accumulates in low-pH compartments. We have used acridine orange accumulation in conjunction with confocal laser scanning microscopy of toxin-treated cells to begin probing the nature and origin of these vacuoles.

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