scholarly journals Wastewater-based Epidemiology for Infectious Diseases: The Foundations and Future Perspectives

2021 ◽  
Vol 44 (5) ◽  
pp. 125-133
Author(s):  
Wakana OISHI ◽  
Yifan ZHU ◽  
Chikako MARUO ◽  
Mayuko SAITO ◽  
Masaaki KITAJIMA ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Future Perspectives

scholarly journals Natural killer cells as a therapeutic tool for infectious diseases - current status and future perspectives

Oncotarget ◽  
2018 ◽  
Vol 9 (29) ◽  
pp. 20891-20907 ◽  
Author(s):  
Stanislaw Schmidt ◽  
Lars Tramsen ◽  
Bushra Rais ◽  
Evelyn Ullrich ◽  
Thomas Lehrnbecher
Keyword(s):  
Natural Killer Cells ◽  
Infectious Diseases ◽  
Natural Killer ◽  
Current Status ◽  
Future Perspectives ◽  
Therapeutic Tool ◽  
Killer Cells

scholarly journals The Use of CRISPR/Cas9 as a Tool to Study Human Infectious Viruses

2021 ◽  
Vol 11 ◽  
Author(s):  
Huafeng Lin ◽  
Gang Li ◽  
Xiangwen Peng ◽  
Aimin Deng ◽  
Lei Ye ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Infectious Diseases ◽  
Food Industry ◽  
Gene Editing ◽  
Agricultural Practices ◽  
Clinical Settings ◽  
Future Perspectives ◽  
Biological Feature ◽  
B Virus ◽  
Immunodeficiency Virus

Clustered regularly interspaced short palindromic repeats (CRISPR) systems are a set of versatile gene-editing toolkit that perform diverse revolutionary functions in various fields of application such as agricultural practices, food industry, biotechnology, biomedicine, and clinical research. Specially, as a novel antiviral method of choice, CRISPR/Cas9 system has been extensively and effectively exploited to fight against human infectious viruses. Infectious diseases including human immunodeficiency virus (HIV), hepatitis B virus (HBV), human papillomavirus (HPV), and other viruses are still global threats with persistent potential to probably cause pandemics. To facilitate virus removals, the CRISPR/Cas9 system has already been customized to confer new antiviral capabilities into host animals either by modifying host genome or by directly targeting viral inherent factors in the form of DNA. Although several limitations and difficulties still need to be conquered, this technology holds great promises in the treatment of human viral infectious diseases. In this review, we will first present a brief biological feature of CRISPR/Cas9 systems, which includes a description of CRISPR/Cas9 structure and composition; thereafter, we will focus on the investigations and applications that employ CRISPR/Cas9 system to combat several human infectious viruses and discuss challenges and future perspectives of using this new platform in the preclinical and clinical settings as an antiviral strategy.

“Big Three” Infectious Diseases: Tuberculosis, Malaria and HIV/AIDS

2021 ◽  
Vol 21 ◽  
Author(s):  
Parameshwar Makam ◽  
Ramkishore Matsa
Keyword(s):  
Infectious Diseases ◽  
Current Status ◽  
Lower Income ◽  
Future Perspectives ◽  
Comprehensive Overview ◽  
Modern Era ◽  
Hiv Aids

: Infectious diseases have been evolving and re-evolving over the ages and causing immense misery to humans. Among them, some have been prevented and eradicated, but few are still threatening the modern era since their origin. The majority of these infectious diseases are poverty-driven, hence highly prevalent in the lower-income and mid-income countries of Africa and Asia. The world’s deadliest infections, including Tuberculosis, Malaria and HIV/AIDS, have been considered as the “Big Three” infectious diseases (BTIDs). With leading infections and deaths every year, the BTIDs have been recognized as the world’s greatest pandemics. In light of these alarming situations, this review has been aimed to provide a comprehensive overview of the current status of chemotherapeutics, associated challenges and future perspectives of BTIDs.

scholarly journals Deep Learning Driven Drug Discovery: Tackling Severe Acute Respiratory Syndrome Coronavirus 2

2021 ◽  
Vol 12 ◽  
Author(s):  
Yang Zhang ◽  
Taoyu Ye ◽  
Hui Xi ◽  
Mario Juhas ◽  
Junyi Li
Keyword(s):  
Deep Learning ◽  
Drug Discovery ◽  
Severe Acute Respiratory Syndrome ◽  
Infectious Diseases ◽  
Broad Spectrum ◽  
Antimicrobial Compounds ◽  
Discovery Process ◽  
Future Perspectives ◽  
Drug Discovery Process ◽  
Drug Candidates

Deep learning significantly accelerates the drug discovery process, and contributes to global efforts to stop the spread of infectious diseases. Besides enhancing the efficiency of screening of antimicrobial compounds against a broad spectrum of pathogens, deep learning has also the potential to efficiently and reliably identify drug candidates against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Consequently, deep learning has been successfully used for the identification of a number of potential drugs against SARS-CoV-2, including Atazanavir, Remdesivir, Kaletra, Enalaprilat, Venetoclax, Posaconazole, Daclatasvir, Ombitasvir, Toremifene, Niclosamide, Dexamethasone, Indomethacin, Pralatrexate, Azithromycin, Palmatine, and Sauchinone. This mini-review discusses recent advances and future perspectives of deep learning-based SARS-CoV-2 drug discovery.

Use of MALDI-TOF mass spectrometry in the battle against bacterial infectious diseases: recent achievements and future perspectives

2017 ◽  
Vol 14 (3) ◽  
pp. 253-267 ◽  
Author(s):  
Vassilios Sandalakis ◽  
Ioannis Goniotakis ◽  
Iosif Vranakis ◽  
Dimosthenis Chochlakis ◽  
Anna Psaroulaki
Keyword(s):  
Mass Spectrometry ◽  
Infectious Diseases ◽  
Future Perspectives ◽  
Maldi Tof Mass Spectrometry ◽  
Maldi Tof

scholarly journals COVID‐19: Emergence of Infectious Diseases, Nanotechnology Aspects, Challenges, and Future Perspectives

2020 ◽  
Vol 5 (25) ◽  
pp. 7521-7533
Author(s):  
Akanksha Gupta ◽  
Sanjay Kumar ◽  
Ravinder Kumar ◽  
Ashish Kumar Choudhary ◽  
Kamlesh Kumari ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Future Perspectives

scholarly journals 18F-FDG PET/CT contribution to tuberculous vertebral osteomyelitis diagnosis: a case report

2020 ◽  
Vol 2020 (9) ◽  
Author(s):  
Katerina Manika ◽  
Maria Kipourou ◽  
Stamata Georga ◽  
Eleni Faniadou ◽  
Georgios Pilianidis ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Fever Of Unknown Origin ◽  
Extrapulmonary Tuberculosis ◽  
Vertebral Osteomyelitis ◽  
Unknown Origin ◽  
Future Perspectives ◽  
Valuable Contribution ◽  
Delay In Diagnosis ◽  
Pet Ct ◽  
Fdg Pet Ct

ABSTRACT Tuberculous vertebral osteomyelitis (TVO) is an extrapulmonary tuberculosis form characterized by difficulty and delay in diagnosis. PET/CT is a valuable, well-established tool in the diagnostic workup of cancer and fever of unknown origin, which is increasingly appreciated in the management of infectious diseases. We report a TVO case where PET/CT had a valuable contribution towards diagnosis and monitoring of treatment response, highlighting its advantages and future perspectives when dealing with infectious diseases.

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