scholarly journals Recurrent Disease in Juvenile Differentiated Thyroid Carcinoma: Prognostic Factors, Treatments, and Outcomes

2014 ◽  
Vol 55 (5) ◽  
pp. 710-717 ◽  
Author(s):  
J. Mihailovic ◽  
K. Nikoletic ◽  
D. Srbovan
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Recurrent Disease ◽  
Differentiated Thyroid Carcinoma

scholarly journals Prognostic Factors in Patients with Multiple Recurrences of Well-Differentiated Thyroid Carcinoma

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Theresa Holler ◽  
Jenna Theriault ◽  
Richard J. Payne ◽  
Jonathan Clark ◽  
Spiro Eski ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Univariate Analysis ◽  
Mount Sinai Hospital ◽  
Differentiated Thyroid Carcinoma ◽  
Multiple Treatment ◽  
Time To Recurrence ◽  
Stage Disease ◽  
Well Differentiated ◽  
Multiple Recurrences

Introduction.Patients with multiple recurrences of well-differentiated thyroid carcinoma (WDTC) have markedly reduced overall survival when compared with those who have 1 recurrence of their disease. The purpose of this investigation is to identify prognostic factors for mortality in this subgroup.Methods.Patients with multiple recurrences of WDTC were retrospectively identified from the thyroid cancer database at Mount Sinai Hospital, Toronto (1963–2000). Data on patient, tumor, and recurrence characteristics were collected, and each patient was given aMACIS score.Results.A total of 31 patients were identified (11 male, 20 female; 16–83 years). Using univariate analysis, age 45, stage disease, distant metastasis, vascular invasion, MACIS score 6, and time to recurrence of 12 months were found to be significant predictors for mortality in this subgroup.Conclusions.Patients with multiple recurrences of WDTC follow a distinct clinical course, marked with multiple treatment failures and a substantial risk of mortality.

Differentiated thyroid carcinoma: survival and prognostic factors

2011 ◽  
Vol 58 (4) ◽  
pp. 157-162
Author(s):  
Julia Sastre Marcos ◽  
Ofelia Llamazares Iglesias ◽  
Almudena Vicente Delgado ◽  
Amparo Marco Martínez ◽  
Bárbara Cánovas Gaillemin ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma

Prognostic Factors of Outcome in Poorly Differentiated Thyroid Carcinoma

2005 ◽  
Vol 133 (2) ◽  
pp. P95-P95
Author(s):  
D HILTZIK ◽  
D CARLSON ◽  
A SHAHA ◽  
J SHAH ◽  
B SINGH ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated Thyroid Carcinoma ◽  
Poorly Differentiated

scholarly journals Evaluation of Prognostic Factors Associated With Differentiated Thyroid Carcinoma With Pulmonary Metastasis

2016 ◽  
Vol 41 (12) ◽  
pp. 917-921 ◽  
Author(s):  
Mohsen Qutbi ◽  
Babak Shafeie ◽  
Mahasti Amoui ◽  
Faraj Tabeie ◽  
Zahra Azizmohammadi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Pulmonary Metastasis ◽  
Differentiated Thyroid Carcinoma ◽  
Factors Associated

scholarly journals Evaluating the Prognostic Factors Associated with Cancer-specific Survival of Differentiated Thyroid Carcinoma Presenting with Distant Metastasis

2012 ◽  
Vol 20 (4) ◽  
pp. 1329-1335 ◽  
Author(s):  
Brian Hung-Hin Lang ◽  
Kai Pun Wong ◽  
Chung Yeung Cheung ◽  
Koon Yat Wan ◽  
Chung-Yau Lo
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Distant Metastasis ◽  
Differentiated Thyroid Carcinoma ◽  
Cancer Specific Survival ◽  
Factors Associated

scholarly journals LONG-TERM FOLLOW-UP STUDY OF JUVENILE DIFFERENTIATED THYROID CARCINOMA TREATED BY RADIOACTIVE IODINE

2018 ◽  
pp. 87-95
Author(s):  
J. Mihailovic
Keyword(s):  
Prognostic Factors ◽  
Initial Treatment ◽  
Radioactive Iodine ◽  
Recurrent Disease ◽  
Differentiated Thyroid Carcinoma ◽  
Follow Up Study ◽  
Tumor Multifocality ◽  
Long Term Follow Up

The overall prognosis in pediatric differentiated thyroid carcinoma (DTC) is excellent. Recurrent disease is frequent, however, and requires additional treatment. In this study we retrospectively analyzed the outcome of juvenile DTC treated by radioactive iodine (I-131) during the long-term follow-up study of 29 years. Methods: 54 DTC patients (34 females, 20 males; ≤20 years old, mean age, 16,5 years) were treated with 131I (RAI) with a median follow-up of 13 years. Patients (pts) underwent different initial treatment: 49 pts, TTx+RAI; 2 pts, TTx; and 3 pts, STTx. The probability of recurrence and prognostic factors were tested by Kaplan-Meier’s method. Results: Initially, 37/54 pts achieved complete remission (CR), 16/54 pts partial remission (PR), 1/54 had progressive disease (PG). During the follow-up 11 pts (20,4%) who achieved CR developed recurrent disease (RD); median appearance time, 4 years (range, 1–25 years). Probability of recurrence was 15,8% at 5 years; 20,3% at 10 years, 25,6% at 15, 20 and 26 years after initial treatment. Strong predictive factors of recurrence were age (p=0,0001), initial treatment (p=0,0001), and tumor multifocality (p=0,004), while gender, nodal metastases at presentation, distal metastases at presentation, histological type of the tumor, tumor or T stage and clinical stage showed no influence on relapse (p=0,176; p=0,757; p=0,799; and p=0,822, respectively). Patients with RD, PR and PG were retreated, with surgery or surgery plus RAI, receiving cumulative activity up to 40 GBq. The overall outcome in our patients was excellent: 88,9% CR, 5,55% SD, 1,85% PG, 1,85% DRD, and 1,85% OCD. Conclusion: Younger age at diagnosis, less radical primary surgery without subsequent RAI, and tumor multifocality are strong prognostic factors for recurrence. In order to reduce relapse rate and to improve surveillance for recurrent disease, TTx followed by RAI appears to be the most beneficial initial treatment for patients with juvenile DTC. The use of RAI seems to be safe without adverse effects on subsequent fertility and pregnancy or secondary malignancy.

Prognostic factors in patients with recurrent differentiated thyroid carcinoma

1997 ◽  
Vol 64 (3) ◽  
pp. 202-206 ◽  
Author(s):  
Hideki Asakawa ◽  
Tetsuro Kobayashi ◽  
Yoshifumi Komoike ◽  
Yasuhiro Tamaki ◽  
Yuji Matsuzawa ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma
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