scholarly journals A Sensitive Electrochemical Sensor for Rapid Determination of Mebeverine Hydrochloride and Metronidazole Benzoate Selective Molecular Imprinted Polymer in the PVC Membrane

2018 ◽  
Vol 31 (1) ◽  
pp. 75
Author(s):  
Inas Hasan Mohammed Al Khafaji ◽  
Yehya Kamal Khaleel Al-Bayati
Keyword(s):  
Rapid Determination ◽  
Polymerization Process ◽  
Pvc Membrane ◽  
Imprinted Polymer ◽  
Mebeverine Hydrochloride ◽  
Pentaerythritol Triacrylate ◽  
Pharmaceutical Sample ◽  
Dibutyl Sebacate ◽  
Liquid Electrodes ◽  
Metronidazole Benzoate

    By using precipitation polymerization, liquid electrodes of polymers imprinted with Mebeverine hydrochloride and metronidazole benzoate were created whereas the imprinted polymer (MIP) and non imprinted (NIP) polymers were prepared by using Mebeverine hydrochloride and Metronidazole benzoate qua a template. In the polymerization process, 2-Acrylamido-2-methyl-1-propane Sulphonic acid (AMPS) or 1-Vinylimidazole (VIZ) was used qua monomer, pentaerythritol triacrylate (PETRA) or Divinylbanzene (DVB) was used qua a cross-linker while benzoyl peroxide (BPO) was used as an initiator. The MIP membranes and the membranes of NIP were created by using Dibutyl Sebacate (DBS) and Tris(2-ethylhexyl)phosphate(TEHP) qua plasticizers in PVC matrix. The response time of the liquid electrodes was 1min. whereas their slopes and detection limits reached to 19.62 – 57.36 mV per decade and 1.2 x 10-6 – 2.0 x 10-5 M, respectively. Filling with standard solution of drug (0.1M), the liquid electrodes response -with suitable No.( selectivity for numerous of species - was suitable No.( since pH reached to 1.5 – 12. The developed electrodes were successfully applied for the analyte determination in preparation pharmaceutical sample without any time consuming pretreatment steps.

scholarly journals Synthesis New Liquid Electrodes for Determination Lansoprzole Based on a Molecularly Imprinted Polymer

2020 ◽  
Vol 10 (01) ◽  
pp. 175-182
Author(s):  
Zahraa Mahdi ◽  
Yehya Kamal Al-Bayati
Keyword(s):  
Dibutyl Phthalate ◽  
Limit Of Detection ◽  
Dioctyl Phthalate ◽  
Glycol Dimethacrylate ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Pharmaceutical Sample ◽  
Dimethyl Adipate ◽  
Standard Solution ◽  
Liquid Electrodes

Liquid electrodes of Lansoprazole (LP) imprinted polymer was synthesis based on precipitation polymerization mechanism. The molecularly imprinted (MIP) and non-imprinted (NIP) polymers were synthesized using LP as a template. By methyl methacrylate (MMA) as a monomer, Pentaerythritol tetraacrylate (PTA) and ethylene glycol dimethacrylate (EGDMA) as cross-linkers and benzoyl peroxide (BP) as an initiator. The molecularly imprinted membranes were synthesized using Dimethyl adipate (DMA), Dibutyl phthalate (DBPH), Dioctyl phthalate(DOPH), and Nitrobenzene (NB) as plasticizers in PVC matrix. The slopes and limit of detection of liquid electrodes obtained from the calibration curves ranged from (-17.85– -20.89) mV/decade and 1.8 x 10-5–6.0 x 10-6 M, respectively, and the response time was about 60 seconds. The Liquid electrodes were filled with 10-2 M standard solution of the drug and observed stable response for a pH ranged from 2.0 to 11.0 and with good selectivity for over several species. The fresh electrodes of synthesis were effectively used in the pharmaceutical sample to determine LP without any time-consuming pretreatment measures.

scholarly journals SYNTHESIS OF NEW LEVOFLOXACIN SELECTIVE MEMBRANE SENSOR BASED ON MOLECULARLY IMPRINTED POLYMERS.

2021 ◽  
Vol 13 (1) ◽  
pp. 95-107
Author(s):  
Saja F. Abdullah1 ◽  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Imprinted Polymer ◽  
Standard Drug ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Selective Membrane ◽  
Pharmaceutical Sample ◽  
Liquid Electrodes ◽  
Drug Solution

Two molecular imprinted polymer (MIP) membranes for Levofloxacin (LEV) were prepared based on PVC matrix. The imprinted polymers were prepared by polymerization of styrene (STY) as monomer, N,N methylene di acrylamide as a cross linker ,benzoyl peroxide (BPO) as an initiator and levofloxacin as a template. Di methyl adepate (DMA) and acetophenone (AOPH) were used as plasticizers , the molecular imprinted membranes and the non molecular imprinted membranes were prepared. The slopes and detection limits of the liquid electrodes ranged from -21.96 – -19.38 mV/decade and 2×10-4M- 4×10-4M, and Its response time was around 1 minute, respectively. The liquid electrodes were packed with 0.1 M standard drug solution and its response were stable at pH ranges from 1.0 to 11.0 and with good selectivity for more than several type. The electrodes produced have been successfully applied in preparation of the pharmaceutical sample for the determination of the analyte without any time consuming pretreatment steps.

scholarly journals SYNTHESIS NEW LIQUID ELECTRODES FOR DETERMINATION DOMPERIDONE MALEATE BASED ON A MOLECULARLY IMPRINTED POLYMER

2020 ◽  
Vol 12 (2) ◽  
pp. 93-105
Author(s):  
زهراء مهدي1 ◽  
◽  
يحيى كمال البياتي2 ◽  
Keyword(s):  
Ethylene Glycol ◽  
Response Time ◽  
Molecularly Imprinted Polymer ◽  
Limit Of Detection ◽  
Glycol Dimethacrylate ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Pharmaceutical Sample ◽  
Standard Solution ◽  
Liquid Electrodes

Liquid electrodes of domperidone maleate (DOMP) imprinted polymer were synthesis based on precipitation polymerization mechanism. The molecularly imprinted (MIP) and non-imprinted (NIP) polymers were synthesized using DOMP as a template. By methyl methacrylate (MMA) as monomer, N,Nmethylenebisacrylamide (NMAA) and ethylene glycol dimethacrylate (EGDMA) as cross-linkers and benzoyl peroxide (BP) as an initiator. The molecularly imprinted membranes were synthesis using acetophenone (APH), di-butyl sabacate (DBS), Di octylphthalate (DOPH) and triolyl phosphate (TP)as plasticizers in PVC matrix. The slopes and limit of detection of liquid electrodes obtained from the calibration curves ranged from (-18.88– -29.01) mV/decade and (4.0 × 10-5 – 6.0 × 10-5) M, respectively and the response time was about 60 seconds. The Liquid electrodes were filled with (10-2 M) standard solution of the drug and observed stable response for a pH ranged from 2.0 to 11.0 and with good selectivity for over several species. The fresh electrodes of synthesis were effectively used in the pharmaceutical sample to determine DOMP without any time consuming pretreatment measures.

scholarly journals PENGARUH MILLING TERHADAP KARAKTERISTIK MOLECULARLY IMPRINTED POLYMER KARBARIL (C12H11NO2)

2020 ◽  
Vol 5 (2) ◽  
pp. 1-5
Author(s):  
Suci Aprilia
Keyword(s):  
Thermal Decomposition ◽  
Ethylene Glycol ◽  
Molecularly Imprinted Polymer ◽  
Extraction Process ◽  
High Energy ◽  
Polymerization Process ◽  
Cross Linking ◽  
Glycol Dimethacrylate ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Molecularly Imprinted Polymer (MIP) has been synthesized with carbaryl used as a template and forms complex bonds with Methacrylic Acid (MAA)through hydrogen bonds, followed by a cross-linking process using Ethylene Glycol Dimethacrylate (EGDMA) cross-linkers. The polymerization process begins with the thermal decomposition of Benzoyl Peroxide (BPO) as an initiator. Non-Imprinted Polymer (NIP) as a control polymer has also been synthesized using a similar procedure without using carbaryl templates. In this study, two variations of carbaryl are used, which are not milled carbamates, and carbaryl has been milled using High Energy Milling (HEM). The FTIR study was carried out to investigate the presence of carbaryl in polymers, MIP, and NIP. The spectrum shows that the concentration of carbaryl compound decreases after the extraction process. This result was also confirmed by the increase in the value of the percentage of transmittance in the MIP, especially the nano carbaryl MIP. This result is supported by the X-RD results, which showed a decrease in the size of the crystals in the carbaryl MIP from 10.07 Å while the nano carbaryl MIP was 9.16 Å.

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