scholarly journals The Significance of Cytoskeleton System in Tumor Cell Infiltration

2021 ◽  
Vol 4 (2) ◽  
pp. 51
Author(s):  
Han Yu ◽  
Likun Liu ◽  
Shulan Hao
Keyword(s):  
Tumor Cell ◽  
Complex Network ◽  
Intermediate Filaments ◽  
Cell Invasion ◽  
Tumor Invasion ◽  
Signal Transmission ◽  
Tumor Cell Invasion ◽  
Eukaryotic Cells ◽  
Material Transport ◽  
In Cells

Cytoskeleton system is mainly composed of three kinds of fibrils: microtubules, microfilaments and intermediate filaments. They are a complex network of protein filaments in the cytoplasm of eukaryotic cells. They not only act as scaffolds in cells, but also play an important role in maintaining the movement of cells, participating in the material transport and signal transmission in cells. It is found that the whole cytoskeleton system is closely related to tumor invasion and growth. Therefore, this article reviews the overview of the cytoskeleton system and its significance for tumor cell invasion and growth.

scholarly journals Pathological Investigation of Meningioma Capsule with respect to Tumor Cell Invasion

2021 ◽  
Author(s):  
Takashi Sugawara ◽  
Daisuke Kobayashi ◽  
Taketoshi Maehara
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Invasion ◽  
Tumor Invasion ◽  
Recurrence Risk ◽  
Tumor Cell Invasion ◽  
Brain Surface ◽  
Eloquent Cortex ◽  
The Brain

Abstract OBJECTIVE No previous study has pathologically investigated whether the meningioma capsule presents with tumor cells. We investigated which types of tumor capsules include tumor cells to help decide the kind of capsules which can be left intraoperatively without recurrence risk. METHODS We investigated 22 specimens of 14 newly diagnosed meningiomas between February 2011 and June 2021. Capsules were classified into three types: tumor capsule (TC), capsule-like thickened arachnoid membrane (CAM), and extended membrane (EM). Capsule properties were scored as hardness (soft = 1, medium = 2, hard = 3) and transparency (high = 1, medium = 2, low = 3). Hardness, transparency, and score sum was compared between capsules with/without tumor invasion in CAM and EM types. RESULTS The mean follow-up duration was 28.1 months, and there was only one recurrence in a remote location from the residual capsule. Nine capsules were classified as TC, seven as CAM, and six as EM. 88.9% of TCs, 42.9% of CAMs, and 50% of EMs were invaded by tumor cells. Hardness, transparency, and score sum in CAM with tumor invasion was lower than in CAM without, but not significant (p = 0.114, p = 0.114, p = 0.057). CONCLUSION Thickened TC or soft and highly transparent CAM imply a high risk of tumor cell invasion, thus such cases should be followed up long and carefully. The hard and low transparent residual CAMs may have low risk of tumor invasion, thus these kinds of residual capsules might not increase the recurrence risk. Thus, leaving such capsules tightly adhered to the eloquent cortex is theoretically justified to avoid damaging the brain surface.

CUTL1–a modulator of tumor cell invasion and target of TGF-beta which is highly expressed in colon cancer

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
P Michl ◽  
M Ei'Bahrawy ◽  
R Poulsom ◽  
A Ramjaun ◽  
J Downward
Keyword(s):  
Colon Cancer ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Tgf Beta

Tumor Cell Invasion Assay

BIO-PROTOCOL ◽  
2012 ◽  
Vol 2 (3) ◽  
Author(s):  
Yanling Chen
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Invasion Assay

scholarly journals Regulation of CD44 Alternative Splicing by SRm160 and Its Potential Role in Tumor Cell Invasion

2006 ◽  
Vol 26 (1) ◽  
pp. 362-370 ◽  
Author(s):  
Chonghui Cheng ◽  
Phillip A. Sharp
Keyword(s):  
Alternative Splicing ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Rna Splicing ◽  
Tumor Cell Invasion ◽  
Dependent Manner ◽  
Cd44 Isoforms ◽  
Transmembrane Glycoprotein ◽  
Cell Invasiveness ◽  
Interfering Rna

ABSTRACT The multiple isoforms of the transmembrane glycoprotein CD44 are produced by alternative RNA splicing. Expression of CD44 isoforms containing variable 5 exon (v5) correlates with enhanced malignancy and invasiveness of some tumors. Here we demonstrate that SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner. Overexpression of SRm160 stimulates inclusion of CD44 v5 when Ras is activated. Conversely, small interfering RNA (siRNA)-mediated silencing of SRm160 significantly reduces v5 inclusion. Immunoprecipitation shows association of SRm160 with Sam68, a protein that also stimulates v5 inclusion in a Ras-dependent manner, suggesting that these two proteins interact to regulate CD44 splicing. Importantly, siRNA-mediated depletion of CD44 v5 decreases tumor cell invasion. Reduction of SRm160 by siRNA transfection downregulates the endogenous levels of CD44 isoforms, including v5, and correlates with a decrease in tumor cell invasiveness.

scholarly journals Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp.

2010 ◽  
Vol 63 (9) ◽  
pp. 563-565 ◽  
Author(s):  
Yasuhiro Igarashi ◽  
Ryoko Shimasaki ◽  
Satoshi Miyanaga ◽  
Naoya Oku ◽  
Hiroyasu Onaka ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Streptomyces Sp

scholarly journals An Immortalization-Dependent Switch in Integrin Function Up-regulates MMP-9 to Enhance Tumor Cell Invasion

2008 ◽  
Vol 68 (18) ◽  
pp. 7371-7379 ◽  
Author(s):  
John M. Lamar ◽  
Kevin M. Pumiglia ◽  
C. Michael DiPersio
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Enhance Tumor Cell
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