scholarly journals Exploring a possible link between insulin resistance, vaccine to SARS CoV 2 and glycaemic disturbances in diabetes mellitus, type 2

2021 ◽  
Vol 11 (1) ◽  
pp. 229-239
Author(s):  
ASV Prasad
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Diabetes Mellitus Type 2 ◽  
Clinical Syndrome ◽  
Diabetes Mellitus Type ◽  
Future Research ◽  
Exogenous Insulin ◽  
Endogenous Insulin ◽  
Underlying Mechanisms

The occurrence of both hyperglycaemia and hypoglycaemia, individually and in combination is reported in the literature, occurring in various insulin resistance (IR) syndromes, both to endogenous insulin, like Hirata disease, otherwise called the Insulin Autoimmune syndrome (IAS), type A, I R, Type B, IR etc. and to exogenous administered insulin, like, exogenous insulin antibody syndrome, (EIAS), non- classical auto immune syndrome to exogenous insulin, etc. Glycaemic disturbances without IR and in non-diabetics, like idiopathic and symptomatic reactive hypoglycaemias are also described in the literature. This author, recently reported for the first time, a biphasic post - vaccinal syndrome, following vaccination for Covid 19 (Covishield), causing glycemic disturbances in an elderly diabetes mellitus type 2 (DM2) patient on insulin who had moderate IR. Insulin resistance to exogenous insulin observed in the patient, is considered crucial for the occurrence of the observed clinical syndrome as, an increase or decrease of IR, and could explain the observed glycaemic disturbances. The IR to exogenous insulin, and the vaccine to Covid 19, both have immunological basis. The immunological aspects of both IR and the Covid 19 vaccine are briefly reviewed to explore any possible interaction between the two, that could explain the observed clinical syndrome, referred to above. Also, the various underlying mechanisms for the glycaemic disturbances, in the above-mentioned IR syndromes and non-IR or r syndromes are explored as to shed some light on the mechanism of the glycaemic disturbances in the syndrome reported. A hypothesis is suggested, taking into consideration, the aforesaid observations. Apart from IR to exogenous insulin, other unidentified factors that might be causing the clinical syndrome reported, and which might account for its paucity of reporting, need to be investigated by future research.

scholarly journals Dysmetabolic Syndrome in a Man with a Novel Mutation of the Aromatase Gene: Effects of Testosterone, Alendronate, and Estradiol Treatment

2004 ◽  
Vol 89 (1) ◽  
pp. 61-70 ◽  
Author(s):  
Laura Maffei ◽  
Yoko Murata ◽  
Vincenzo Rochira ◽  
Gloria Tubert ◽  
Claudio Aranda ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Diabetes Mellitus Type 2 ◽  
Acanthosis Nigricans ◽  
Diabetes Mellitus Type ◽  
Bone Maturation ◽  
Bilateral Cryptorchidism ◽  
High Doses

We present the fourth case of an adult man (29 yr old) affected by aromatase deficiency resulting from a novel homozygous inactivating mutation of the CYP19 (P450arom) gene. At first observation, continuing linear growth, eunuchoid body proportions, diffuse bone pain, and bilateral cryptorchidism were observed. The patient presented also a complex dysmetabolic syndrome characterized by insulin resistance, diabetes mellitus type 2, acanthosis nigricans, liver steatohepatitis, and signs of precocious atherogenesis. The analysis of the effects induced by the successive treatment with high doses of testosterone, alendronate, and estradiol allows further insight into the roles of androgens and estrogens on several metabolic functions. High doses of testosterone treatment resulted in a severe imbalance in the estradiol to testosterone ratio together with the occurrence of insulin resistance and diabetes mellitus type 2. Estrogen treatment resulted in an improvement of acanthosis nigricans, insulin resistance, and liver steatohepatitis, coupled with a better glycemic control and the disappearance of two carotid plaques. Furthermore, the study confirms previous data concerning the key role of estrogens on male bone maturation, at least in part, and regulation of gonadotropin secretion. The biopsy of the testis showed a pattern of total germ cell depletion that might be due to the concomitant presence of bilateral cryptorchidism. Thus, a possible role of estrogen in male reproductive function is suggested but without revealing a direct cause-effect relationship. Data from this case provide new insights into the role of estrogens in glucose, lipid, and liver metabolism in men. This new case of aromatase deficiency confirms previous data on bone maturation and mineralization, and it reveals a high risk for the precocious development of cardiovascular disease in young aromatase-deficient men.

scholarly journals INFLUENCE OF BETA-BLOCKERS ON INSULIN RESISTANCE IN PATIENTS WITH DIABETES MELLITUS TYPE 2

2011 ◽  
pp. 23-28 ◽  
Author(s):  
Ivana Damnjanović ◽  
Radmila Veličković-Radovanović ◽  
Radivoj Kocić ◽  
Snežana Zlatković-Guberinić ◽  
Danka Sokolović ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Diabetes Mellitus Type 2 ◽  
Beta Blockers ◽  
Diabetes Mellitus Type ◽  
Patients With Diabetes

scholarly journals THE RELATIONSHIP BETWEEN CALPROTECTIN AND PARAMETERS OF LIPID AND CARBOHYDRATE METABOLISM, ANTHROPOMETRIC AND INFLAMMATORY PARAMETERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2

2019 ◽  
Vol 19 (2) ◽  
pp. 16-18
Author(s):  
M. I. Zhuravlova
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Insulin Resistance ◽  
Acute Myocardial Infarction ◽  
Carbohydrate Metabolism ◽  
Diabetes Mellitus Type 2 ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
The Relationship

Nowadays, an acute myocardial infarction is one of the leading causes of mortality among the population. The EHS-DH registry data clearly illustrate the association between the comorbidities and high mortality following acute myocardial infarction during a year period of follow up. The pronounced influence of carbohydrate metabolism disturbances on the survival of such patients has already been reported. The aim of the study was to analyze the immune inflammation relationships based on assessing calprotectin and the parameters of lipid and carbohydrate metabolism, to evaluate the presence and nature of the relationship between these parameters and carbohydrate metabolism parameters based on the study of blood glucose, insulin and insulin resistance (by the indices HOMA, QUICKI, Caro), anthropometric indicators and inflammatory indicators (monocyte and neutrophile levels). Materials and methods. The study included 64 patients (mean age 65, 31 ± 1.62 years) with acute myocardial infarction and concomitant diabetes mellitus type 2. The design of the study included the primary laboratory investigation of patients during the first day since the onset of acute myocardial infarction with the elevation of the ST segment before the initiation of thrombolytic therapy or percutaneous intervention. The direct correlation between the calprotectin concentration and the HOMA insulin resistance index (R = 0.52; p <0.05), insulinemia (R = 0.57; p <0.05), fasting glycaemia (R = 0, 59; p <0.05), as well as inverse correlation relationships between the Caro index (R = 0.68; p <0.05) and the QUICKI index (R = 0.59; p <0.05) were found out. Moreover, a direct correlation between calprotectin and triglyceride levels (R = 0.31; p <0.05), and negative correlation with high density lipoprotein (R = 0.35; p <0.05) was established as well. The level of total cholesterol and low density lipoproteins showed no significant association with the proinflammatory factor (R = 0.12; p> 0.05 and R = 0.18; p> 0.05, respectively). Conclusions. The increase in the body mass index and the activity of serum monocytes and neutrophils is associated with high concentrations of calprotectin that is accompanied by disturbances of carbohydrate homeostasis towards the growth of insulin resistance and changes of lipidograms of proatherrogenic nature.

Urinary Iodine is Associated with Insulin Resistance in Subjects with Diabetes Mellitus Type 2

2012 ◽  
Vol 120 (10) ◽  
pp. 618-622 ◽  
Author(s):  
O. Al-Attas ◽  
N. Al-Daghri ◽  
K. Alkharfy ◽  
M. Alokail ◽  
N. Al-Johani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Diabetes Mellitus Type 2 ◽  
Urinary Iodine ◽  
Diabetes Mellitus Type

scholarly journals Lipid-proteinic interaction in erythrocytie and placental membranes in women with insulin resistance

2012 ◽  
Vol 58 (2) ◽  
pp. 224-229
Author(s):  
N.P. Mikaelyan ◽  
A.A. Terentyev ◽  
A.G. Maxina ◽  
A.V. Mikaelyan ◽  
S.V. Novikova
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Pregnant Women ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Erythrocyte Membranes ◽  
Obesity And Diabetes ◽  
Placental Membranes ◽  
Lipid Spectrum

Disturbances of erythrocyte and placental membrane functiond have been studied in placenta of pregnant women with obesity and diabetes mellitus type 2. The results of this study demonstrate significant metabolic impairments in women with insulin resistance. Changes in lipid spectrum of erythrocyte membranes and decreased activity of antioxidant enzymes obviously contribute to the development of fetoplacental insufficiency. This changes point to necessity of the antioxidant therapy in pregnant women with obesity and diabetes mellitus type 2.

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