scholarly journals ON THE ISSUE OF SAFETY OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

2018 ◽  
Vol 6 (3) ◽  
pp. 123-129
Author(s):  
N. Yu. Velts ◽  
T. M. Bukatina ◽  
E. O. Zhuravleva ◽  
G. V. Kutekhova ◽  
M. A. Darmostukova ◽  
...  
Keyword(s):  
Active Substance ◽  
Current Practice ◽  
Individual Case ◽  
Self Administration ◽  
Over The Counter ◽  
Nsaid Group ◽  
Daily Dose ◽  
Inflammatory Drugs ◽  
The Russian Federation ◽  
Anti Inflammatory

Non-steroidal anti-inflammatory drugs (NSAIDs) are liders in selling both in the Russian Federation and worldwide. The combination of  analgesic, anti-inflammatory and antipyretic effects make the drugs  of this group very popular in patients with various diseases. The  realization of NSAIDs in pharmacies occurs both by prescription and  over-the-counter, so the safety assessment of the use of this group  of drugs remains relevant. In the current practice, self-administration (responsible selfmedication) of drugs of the NSAID  group is an additional factor affecting the safety of their intake. According to the studies, about 40 % of patients taking  NSAIDs consider that NSAIDS are absolutely safe, and more than 30  % of those taking OTC NSAIDs use them in excess of the  recommended dosages. We analyzed 3963 individual case safety  reports (ICSR) in the federal database «Pharmacovigilance» from  07.12.2008 to 31.08.2017. The inclusion criterions was the presence of information on the off-label application of NSAIDs in the ICSR,  reports of adverse effects that may be associated with the use of this drug or erroneous reports on the active substance, which was  not present in this drug. The most frequent mistakes in the  application were an increase of the daily dose, a change in the  method of administration to patient who are contraindicated with this drug. There were 9 ICSR of burning sensation in the anus with the  introduction of ibuprofen suppositories (not in the label), and 7 ICSR  of ineffectiveness of the active substance, which was not present in this drug.

scholarly journals Defined Daily Dose and Appropriateness of Clinical Application: The Coxibs and Traditional Nonsteroidal Anti-Inflammatory Drugs for Postoperative Orthopaedics Pain Control in a Private Hospital in Malaysia

Pharmacy ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 235
Author(s):  
Faizah Safina Bakrin ◽  
Mohd Makmor-Bakry ◽  
Wan Hazmy Che Hon ◽  
Shafeeq Mohd Faizal ◽  
Mohamed Mansor Manan ◽  
...  
Keyword(s):  
Drug Utilization ◽  
Teaching Hospital ◽  
Pain Control ◽  
Orthopaedic Surgery ◽  
Prescribing Patterns ◽  
World Health ◽  
Defined Daily Dose ◽  
Daily Dose ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Introduction: Drug utilization of analgesics in a private healthcare setting is useful to examine their prescribing patterns, especially the newer injectable cyclooxygenase (COX)-2 inhibitors (coxibs). Objectives: To evaluate the utilization of coxibs and traditional nonsteroidal anti-inflammatory drugs (tNSAIDs) indicated for postoperative orthopaedic pain control using defined daily dose (DDD) and ratio of use density to use rate (UD/UR). Method: A retrospective drug utilization review (DUR) of nonsteroidal anti-inflammatory drugs (NSAIDs) at an inpatient department of a private teaching hospital in Seremban, Malaysia was conducted. Patients’ demographic characteristics, medications prescribed, clinical lab results, visual analogue scale (VAS) pain scores and length of hospital stay were documented. Orthopaedic surgeries, namely arthroscopy, reconstructive, and fracture fixation, were included. Stratified random sampling was used to select patients. Data were collected through patients’ medical records. The DDD per 100 admissions and the indicator UD/UR were calculated with the World Health Organization’s DDD as a benchmark. The inclusion criteria were patients undergoing orthopaedic surgery prescribed with coxibs (celecoxib capsules, etoricoxib tablets, parecoxib injections) and tNSAIDs (dexketoprofen injections, diclofenac sodium tablets). Data were analysed descriptively. This research was approved by the academic institution and the hospital research ethics committee. Result: A total of 195 records of patients who received NSAIDs were randomly selected among 1169 cases. In term of the types of orthopaedic surgery, the ratio of included records for arthroscopy:fracture fixation:reconstructive surgery was 55.4:35.9:8.7. Most of the inpatients had low rates of common comorbidities such as cardiovascular disease as supported by their baseline parameters. The majority were not prescribed with other concomitant prescriptions that could cause drug interaction (74.9%), or gastroprotective agents (77.4%). Overall, DDDs per 100 admissions for all NSAIDs were less than 100, except for parecoxib injections (389.23). The UD/UR for all NSAIDs were less than 100, except for etoricoxib tablets (105.75) and parecoxib injections (108.00). Discussion: As per guidelines, the majority (96.9%) received other analgesics to ensure a multimodal approach was carried out to control pain. From the UD/UR results, the arthroscopy surgery was probably the most appropriate in terms of NSAID utilization. Conclusion: The prescribing pattern of NSAIDs except parecoxib was appropriate based on adverse effect and concurrent medication profile. The findings of this DUR provide insight for a low-risk patient population at a private specialized teaching hospital on the recommended use of NSAIDs for postoperative orthopaedic pain control.

scholarly journals Phenanthrenes in Chinese Yam Peel Exhibit Anti-inflammatory Activity, as Shown by Strong in Vitro Cyclooxygenase Enzyme Inhibition

2016 ◽  
Vol 11 (9) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Qian Li ◽  
Chuan-Rui Zhang ◽  
Amila A. Dissanayake ◽  
Qun-yu Gao ◽  
Muraleedharan G. Nair
Keyword(s):  
Food Item ◽  
Inflammatory Activity ◽  
Spectroscopic Methods ◽  
Over The Counter ◽  
Chinese Yam ◽  
Inflammatory Drugs ◽  
In Vitro Bioassays ◽  
Anti Inflammatory ◽  
Cox 1

Chinese yam ( Dioscorea opposita), peeled or whole, is a popular food item that is considered to be healthy. Often, the yam is peeled before cooking. However, it is also consumed with peel. Therefore, in this study, the peel of this yam was extracted sequentially with n-hexane, ethyl acetate and methanol, and studied for its health-benefits, using in vitro bioassays. Bioactivity-guided purifications of extracts of the peel afforded phenanthrenes (1-4), as characterized by spectroscopic methods. Phenanthrene 1 is a novel analogue. The extracts and isolates were tested for anti-inflammatory activity using cyclooxygenase enzyme (COX-1 and -2) inhibitory assays. All phenanthrenes isolated from the yam peel showed higher inhibition of COX enzymes than the over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, ibuprofen and naproxen.

scholarly journals Microanalysis of Selected NSAIDs Using the Spectrophotometric Method

Eng ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 211-221
Author(s):  
Paweł Gumułka ◽  
Monika Dąbrowska ◽  
Małgorzata Starek
Keyword(s):  
Quality Control ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Pharmacokinetic Studies ◽  
Over The Counter ◽  
Nsaid Group ◽  
Inflammatory Drugs ◽  
Drug Quality Control ◽  
Uv Range

Non-steroidal anti-inflammatory drugs (NSAIDs) are the group of drugs most commonly used in medicine. They are available over the counter to treat fevers and pains of various origins. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for drug quality control, pharmacodynamic and pharmacokinetic studies. This article presents the spectrophotometric method that was used to analyze selected drugs from the NSAID group. The conditions for the determination of selected coxibs and oxicams in the UV range with the use of microplates have been developed. The presented procedure has been validated in accordance with the requirements, guaranteeing reliable results. The obtained results give the basis for the conclusion that the method can be successfully used in the quality control of pharmaceutical preparations with a small amount of available sample.

scholarly journals Assessment of literacy and numeracy skills related to non-steroidal anti-inflammatory drug labels

2019 ◽  
Vol 7 ◽  
pp. 205031211983411 ◽  
Author(s):  
Soo Min Jang ◽  
Ruixin Jiang ◽  
Darren Grabe ◽  
Amy Barton Pai
Keyword(s):  
Primary Care ◽  
Health Literacy ◽  
Vital Sign ◽  
Over The Counter ◽  
Inflammatory Drug ◽  
Scale Range ◽  
Inflammatory Drugs ◽  
Newest Vital Sign ◽  
Anti Inflammatory ◽  
Medication Label

Background: Non-steroidal anti-inflammatory drugs are widely used and have a potential for over-the-counter misuse. Limited health literacy is associated with poor health outcomes. Identification of new strategies to assess literacy and numeracy could be useful in targeting effective education initiatives. Objective: To characterize numeracy and literacy skills related to non-steroidal anti-inflammatory drug labels in primary care patients. Methods: Patients were recruited and consented over an 8-month period after their regular primary care visit. Demographic information was collected and two instruments were administered to assess literacy and numeracy skills: (1) a medication label literacy instrument focused on non-steroidal anti-inflammatory drugs (MedLit-NSAID) and (2) a general healthy literacy-screening tool, the Newest Vital Sign. Two questions on the MedLit-NSAID instrument evaluated understanding of the Food and Drug Administration medication guide for non-steroidal anti-inflammatory drugs and the Food and Drug Administration approved over-the-counter label. Results: A total of 145 patients were enrolled. Mean MedLit-NSAID and Newest Vital Sign scores were 6.8 (scale range 0–8) and 4.2 (scale range 0–6), respectively. Higher education level was associated with higher scores for both tools (p ⩽ 0.05). Total MedLit-NSAID scores on average were higher in females compared with males (6.5 vs 6, p = 0.05). Patients with decreased kidney function (n = 18) had significantly lower MedLit-NSAID scores (p ⩽ 0.05). Test–retest scores were not significantly different for MedLit-NSAID (p = 0.32). The correlation between the tools was 0.54 and internal consistency MedLit-NSAID was 0.61. Conclusion: A medication information focused instrument provided specific information to assess health literacy related to non-steroidal anti-inflammatory drug labels. This information could be utilized to develop patient education initiatives for medication label comprehension.

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