Brimonidine Tartrate | ScienceGate

A simple, accurate and precise UV spectrophotometric method has been developed for the simultaneous estimation of brimonidine tartrate (BRT) and brinzolamide (BRZ) using methanol as solvent. The λmax for BRT and BRZ were found to be 244 nm and 253 nm, respectively. The linearity was found in the range of 1-7 μg/mL and 5- 35 μg/mL for BRT and BRZ, respectively. The LOD and LOQ for BRT were found to be 0.0149 µg/mL and 0.0425 µg/mL at 244 nm and 0.0278 µg/mL and 0.0843 µg/mL at 253 nm, respectively whereas those for BRZ were found to be 0.0330 µg/mL and 0.1000 µg/mL at 244 nm and 0.0243 µg/mL and 0.0737 µg/mL at 253 nm, respectively. The % recovery of the drugs by the proposed method was found in the range of 98.29% to 100.82%. The method was found to be precise and robust. The method was successfully applied for determination of BRT and BRZ in an in-house suspension.

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DESIGN AND EVALUATION OF CONTROLLED-RELEASE OCULAR INSERTS OF BRIMONIDINE-TARTRATE AND TIMOLOL MALEATE

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i1.15199 ◽

2016 ◽

Vol 9 (1) ◽

pp. 79 ◽

Cited By ~ 2

Author(s):

Preethi G. B. ◽

Prashanth Kunal

Keyword(s):

Controlled Release ◽

Drug Release ◽

Sodium Alginate ◽

Calcium Chloride ◽

Release Kinetics ◽

Water Soluble ◽

Moisture Loss ◽

Timolol Maleate ◽

Brimonidine Tartrate

Objective: The current work was attempted to formulate and evaluate a controlled-release matrix-type ocular inserts containing a combination of brimonidine tartrate and timolol maleate, with a view to sustain the drug release in the cul-de-sac of the eye.Methods: Initially, the infrared studies were done to determine the drug–polymer interactions. Sodium alginate-loaded ocuserts were prepared by solvent casting technique. Varying the concentrations of polymer—sodium alginate, plasticizer—glycerine, and cross-linking agent—calcium chloride by keeping the drug concentration constant, made a total of nine formulations. These formulations were evaluated for its appearance, drug content, weight uniformity, thickness uniformity, percentage moisture loss, percentage moisture absorption, and in vitro release profile of the ocuserts. Finally, accelerated stability studies and the release kinetics were performed on the optimised formulation.Results: It was perceived that polymer, plasticizer, and calcium chloride had a significant influence on the drug release. The data obtained from the formulations showed that formulation—F9 was the optimised formulation, which exhibited better drug release. The release data of the optimised formulation tested on the kinetic models revealed that it exhibited first-order release kinetics. Conclusion: It can be concluded that a natural bioadhesive hydrophilic polymer such as sodium alginate can be used as a film former to load water soluble and hydrophilic drugs like brimonidine tartrate and timolol maleate. Among all formulations, F9 with 400 mg sodium alginate, 2% calcium chloride and 60 mg glycerin were found to be the most suitable insert in terms of appearance, ease of handling, thickness, in vitro drug release and stability.

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DEVELOPMENT AND CHARACTERIZATION OF IN SITU GEL OF XANTHAN GUM FOR OPHTHALMIC FORMULATION CONTAINING BRIMONIDINE TARTRATE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i7.25221 ◽

2018 ◽

Vol 11 (7) ◽

pp. 277 ◽

Cited By ~ 3

Author(s):

Vazir Ashfaq Ahmed ◽

Divakar Goli

Keyword(s):

Drug Release ◽

Xanthan Gum ◽

Gelation Time ◽

Gel Strength ◽

Eye Drops ◽

In Situ Gel ◽

23 Factorial Design ◽

Brimonidine Tartrate

Objective: The goal of this study was to develop and characterize an ion-activated in situ gel-forming brimonidine tartrate, solution eye drops containing xanthan gum as a mucoadhesive polymer.Method: Sol-gel formulation was prepared using gellan gum as an ion-activated gel-forming polymer, xanthan gum as mucoadhesive agent, and hydroxypropyl methyl cellulose (HPMC E50LV) as release retardant polymer. Phenylethyl alcohol is used as preservatives in borate buffer. The 23 factorial design was employed to optimize the formulation considering the concentration of gelrite, xanthan gum and HPMC as independent variables, gelation time, gel strength, and mucoadhesive force (N). Gelation time , gel strength, mucoadhesive force (N), viscosity (cP) and in vitro percentage drug release were chosen as dependent variables. The formulation was characteristics for pH, clarity, isotonicity, sterility, rheological behavior, and in vitro drug release, ocular irritation, and ocular visualization.Result: Based on desirability index of responses, the formulation containing a concentration of gelrite (0.4%), xanthan gum (0.21%), and HPMC (HPMC E50 (0.24%) was found to be the optimized formulation concentration developed by 23 factorial design. The solution eye drops resulted in an in situ phase change to gel-state when mixed with simulated tear fluid. The gel formation was also confirmed by viscoelastic measurements. Drug release from the gel followed non-fickian mechanism with 88% of drug released in 10 h, thus increased the residence time of the drug.Conclusion: An in situ gelling system is a valuable alternative to the conventional system with added benefits of sustained drug release which may ultimately result in improved patient compliance.

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Demographic and Clinical Factors Associated with Development of Brimonidine Tartrate 0.2%-Induced Ocular Allergy

Journal of Glaucoma ◽

10.1097/00061198-200404000-00014 ◽

2004 ◽

Vol 13 (2) ◽

pp. 163-167 ◽

Cited By ~ 34

Author(s):

Gianluca Manni ◽

Marco Centofanti ◽

Marta Sacchetti ◽

Francesco Oddone ◽

Stefano Bonini ◽

...

Keyword(s):

Ocular Allergy ◽

Clinical Factors ◽

Factors Associated ◽

Brimonidine Tartrate

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Effects of brimonidine tartrate 0.1% ophthalmic solution on the pupil, refraction, and light reflex

Scientific Reports ◽

10.1038/s41598-018-27436-8 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 2

Author(s):

C. O. Sayaka Kato ◽

Kimiya Shimizu ◽

Kazutaka Kamiya ◽

Hitoshi Ishikawa ◽

Akihito Igarashi

Keyword(s):

Ophthalmic Solution ◽

Light Reflex ◽

Brimonidine Tartrate

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FORMULATION DEVELOPMENT AND EVALUATION OF AN IN SITU OPHTHALMIC GELLING SYSTEM OF BRIMONIDINE TARTRATE AND TIMOLOL MALEATE FOR THE TREATMENT OF GLAUCOMA

INDIAN DRUGS ◽

10.53879/id.54.02.10854 ◽

2017 ◽

Vol 54 (02) ◽

pp. 76-78

Author(s):

A Shirodker ◽

◽

S. Bhangle ◽

R. Gude

Keyword(s):

Hydroxypropyl Methylcellulose ◽

In Vitro Release ◽

Content Uniformity ◽

Formulation Development ◽

Timolol Maleate ◽

Release Studies ◽

Brimonidine Tartrate ◽

In Situ Gelling

The present study involved formulation of an in situ gelling system of brimonidine tartrate and timolol maleate for the treatment of glaucoma. Carbopol® 980 NF, xanthum gum and hydroxypropyl methylcellulose K4 M were used as polymers. The prepared in situ gelling systems were evaluated for clarity, appearance, texture analysis, pH, viscosity, rheological properties, in vitro gelation, isotonicity, drug content uniformity, in vitro release studies, microbiological evaluation, ex vivo release studies and stability testing. The results of the attenuated total reflectance spectroscopy and differential scanning calorimetry studies confirmed that there is no incompatibility between the drugs and the excipients. The formulations exhibited pseudoplastic rheology and formulation 3 showed the highest release of both the drugs from the formulation. The stability studies showed that the formulation was stable over the given period of time. Thus, it is evident that the in situ gelling system is a promising drug delivery system for the treatment of glaucoma.

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