Dextromethorphan Hydrobromide

2021 ◽  
Keyword(s):  
Dextromethorphan Hydrobromide

scholarly journals Structure redetermination of dextromethorphan hydrobromide monohydrate, C18H28BrNO2 – localization of hydrogen atoms

2021 ◽  
Vol 236 (2) ◽  
pp. 353-355
Author(s):  
Kina Muller ◽  
Eric C. Hosten ◽  
Richard Betz
Keyword(s):  
Hydrogen Atoms ◽  
Dextromethorphan Hydrobromide

Abstract C18H28BrNO2, orthorhombic, P212121 (no. 19), a = 7.0417(4) Å, b = 9.1635(5) Å, c = 27.3371(15) Å, V = 1763.97(17) Å3, Z = 4, R gt (F) = 0.0275, wR ref (F 2) = 0.0596, T = 200 K.

Preparation and Characterization of a Novel Mixed Functional Cationic Exchange Copolymer Microsphere as Drug Carrier

2012 ◽  
Vol 476-478 ◽  
pp. 2288-2291 ◽  
Author(s):  
Kaewnapa Wongsermsin ◽  
Praneet Opanasopit ◽  
Tanasait Ngawhirunpat ◽  
Prasert Akkaramongkolporn
Keyword(s):  
Drug Carrier ◽  
Gastric Ph ◽  
The Novel ◽  
Electron Micrograph ◽  
Scanning Electron Micrograph ◽  
Cationic Exchange ◽  
The Fourier Transform ◽  
Release Characteristic ◽  
Dextromethorphan Hydrobromide

The objective of the present study was to prepare a novel mixed functional cationic exchange copolymer microsphere containing methyl methacrylic acid and sulfonated styrene crosslinked with divinylbenzene. The emulsion polymerization was used to prepare the cationic exchange copolymer microsphere which was characterized by the scanning electron micrograph (SEM) and the fourier transform infrared spectroscopy (FTIR). The release characteristic of the loaded drug i.e. dextromethorphan hydrobromide from the copolymer microsphere was studied under both simulated gastric (pH 1.2) and intestinal (pH 6.8) conditions. The result showed that the drug released from the novel copolymer microsphere depended on the pH of the release media.

DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF DEXTROMETHORPHAN HYDROBROMIDE AND QUINIDINE SULPHATE IN PHARMACEUTICAL DOSAGE FORM

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (01) ◽  
pp. 35-40
Author(s):  
A. S. Bagde ◽  
V. V. Khanvilkar ◽  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Chromatography Method ◽  
Pharmaceutical Dosage Form ◽  
Liquid Chromatography Method ◽  
Development And Validation ◽  
Dextromethorphan Hydrobromide

The present work describes a validated reverse phase high performance liquid chromatography (RPHPLC) method for simultaneous estimation of dextromethorphan hydrobromide and quinidine sulphate in pharmaceutical dosage from. The drugs were resolved using Hemochrom Intsil C18-5U column (250×4.6) mm in isocratic mode with mobile phase methanol: water (0.08% diethylamine, 0.02% of glacial acetic acid and pH 4.4 adjusted with orthophosphoric acid) in the ratio of 70:30 V/V at a flow rate of 1.0 mL/min. Retention time of dextromethorphan hydrobromide and quinidine sulphate were 4.9±0.2 and 3.6±0.2, respectively, at 292nm. The above mentioned method was validated as per International Conference on Harmonization (ICH) guidelines. Linear responses were obtained in concentration ranges of 5-35 μg/mL for dextromethorphan hydrobromide and 4-16 μg/mL for quinidine sulphate, with correlation coefficient (r2) of 0.999 for both the drugs. A simple, selective, accurate, precise, robust and reliable RP-HPLC method thus developed and validated for simultaneous estimation of dextromethorphan hydrobromide and quinidine sulphate.

FORMULATION AND CHARACTERIZATION OF MEDICATED CHEWING GUMS OF DEXTROMETHORPHAN HYDROBROMIDE

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (12) ◽  
pp. 29-35
Author(s):  
N.G.N Swamy ◽  
◽  
P Shilpa ◽  
Z. Abbas
Keyword(s):  
Drug Release ◽  
Systemic Absorption ◽  
Chewing Gum ◽  
Release Mechanism ◽  
Physical Parameters ◽  
In Vitro Drug Release ◽  
Chewing Gums ◽  
Dextromethorphan Hydrobromide ◽  
Spray Dried

Chewing gums are mobile drug delivery systems, with a potential for administering drugs either for local action or for systemic absorption via buccal route. Dextromethorphan hydrobromide chewing gum formulations were made employing Pharmagum M as the base with an aim to overcome the firstpass effect, reducing the risk of overdosing, ease of administration and for achieving faster systemic absorption. Dextromethorphan hydrobromide was further transformed into spray dried form and incorporated into Pharmagum M base with the object of solubility enhancement and masking the bitter taste of the drug. The prepared medicated chewing gums were evaluated for various precompression and postcompression parameters. The in vitro drug release profiles were carried out employing Erweka DRT chewing apparatus. It was observed that increasing the chewing gum base concentration resulted in a decreased drug release profile. The drug in the spray dried form revealed improved performance in comparison to the directly contained drug. The drug release data were fitted into various kinetic models. It was observed that the drug release was matrix diffusion controlled and revealed a non-Fickian drug release mechanism. Accelerated stability studies were carried out on select formulations as per ICH guidelines. The formulations were found to be stable in respect to physical parameters and no significant deviations were seen in respect to in vitro drug release characteristics.

Development and Validation of Dissolution Study of Sustained Release Dextromethorphan Hydrobromide Tablets

2014 ◽  
Vol 17 (3) ◽  
pp. 429-433
Author(s):  
Sekar Rajan ◽  
Socorrina Colaco ◽  
N. Ramesh ◽  
Subramania Nainar Meyyanatha ◽  
K. Elango
Keyword(s):  
Sustained Release ◽  
Dissolution Study ◽  
Development And Validation ◽  
Dextromethorphan Hydrobromide
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