This chapter presents information on neonatal drugs that begin with S, including use, pharmacology, adverse effects, fetal and infant implications of maternal treatment, treatment, and supply of Salbutamol = Albuterol (USAN), Sildenafil, Skin care and skin sterility, Sodium phenylbutyrate and glycerol phenylbutyrate, Sodium benzoate, Sodium bicarbonate, Sodium chloride, Sodium fusidate (fusidic acid), Sodium valproate, Sotalol, Spiramycin, Spironolactone, Stiripentol, Streptokinase, Sucrose, Sulfadiazine = Sulphadiazine (former BAN), Surfactants, and Suxamethonium = Succinylcholine (USAN)