Prolactin level correction in restoration of menstrual cycle in obese women

Obesity is a common problem among women of reproductive age. There are data from clinical and experimental studies indicating the role of hyperprolactinemia in the development of metabolic syndrome, as well as the metabolic benefits of treating hyperprolactinemia.Research objective: to evaluate the clinical efficacy of Vitex Agnus Castus standardized extract on hormonal and metabolic status in women with menstrual cycle disorders and obesity.Materials and methods. 60 women aged 19 to 35 years with obesity and menstrual cycle disorders with laboratory-confirmed insulin resistance and prolactin near the upper limit of the reference values or was slight increase were examined. All the patients were given recommendations for lifestyle modification. 30 of them, who formed the main group, received Cyclodynon. 30 patients of the control group were not prescribed Cyclodynon therapy.Results. At the end of the treatment, the menstrual cycle was normalized in 93.3% patients of the main group, and in 66.3% patients of the control group (p < 0.05). Ovulation signs were detected in 86.67% women of the main group and only in 30.0% women of the control group (p < 0.05). The mean prolactin value and the HOMA index were significantly lower in the main group; prolactin level did not exceed the physiological values in 86.67% women in the main group after 6 months, and in 40.0% of the control group, p < 0.05. There was a decrease in body mass index and waist/hip circumference ratio in patients of the studied groups; the dynamics was slightly higher in the main group but did not differ significantly. Conclusions. Cyclodynon is effective for the treatment of menstrual cycle disorders and metabolic disorders in women with obesity and metabolic syndrome. Good tolerability, absence of side effects, and sufficient efficacy of Cyclodynon allow it to be recommended as the drug of choice in patients with prolactin levels near the upper limit of the reference values or a slight increase of it and in patients with intolerance to synthetic dopamine agonists.

ASSESSMENT OF RESIDUAL EFFECTS AND CONSEQUENCES OF COVID-19 IN ELDERLY AND SENILE PEOPLE IN SHYMKENT

Первые случаи COVID-19 в Казахстане начали регистрироваться в марте 2020г. и на середину июля по официальным данным было уже зарегистрировано почти 60 тысяч случаев, в том числе 373 летальных (0,6%). Понимание истинного бремени заболевания является важным для усиления системы общественного здравоохранения и своевременного корректирования карантинных и смягчающих мер в современном мире. Название инфекции COVID-19 появилось благодаря англоязычной аббревиатуре «Coronavirus Disease 2019». Большая часть пациентов с COVID-19 полностью выздоравливает. Однако, у части из них остаются остаточные явления - одышка при легкой физической нагрузке, легкий кашель, боли и дискомфорт в области лопаток, ухудшение показателей функции сердца, отсутствие обоняния и вкуса, снижение зрения, повышенная утомляемость, бессонница, нарушение менструального цикла, выпадение волос, депрессивное состояние. Остаточные явления в значительной степени снижают качество жизни пациентов, особенно у лиц пожилого и старческого возраста, переболевших COVID-19, мешая вести прежний образ жизни, ухудшая работоспособность и способность выдерживать психоэмоциональные нагрузки. В данной статье проведена оценка остаточных явлений и последствий COVID-19 у лиц пожилого и старческого возраста г. Шымкент. The first cases of COVID-19 in Kazakhstan began to be registered in March 2020. and by mid-July, according to official data, almost 60 thousand cases were already registered, including 373 fatal (0.6%). Understanding the true burden of the disease is important for strengthening the public health system and timely correction of quarantine and mitigation measures in the modern world. The name of the COVID-19 infection appeared due to the English-language abbreviation «Coronavirus Disease 2019». Most of the patients with COVID-19 fully recover. However, some of them have residual phenomena-shortness of breath with light physical exertion, a slight cough, pain and discomfort in the shoulder blades, deterioration of heart function, lack of smell and taste, decreased vision, increased fatigue, insomnia, menstrual cycle disorders, hair loss, depression. Residual phenomena significantly reduce the quality of life of patients, especially in elderly and senile people who have had COVID-19, preventing them from leading a previous lifestyle, impairing their performance and ability to withstand psychoemotional loads. This article evaluates the residual effects and consequences of COVID-19 in elderly and senile people in Shymkent.

DESCRIPTION OF MENSTRUAL CYCLE DISORDERS IN 3 MONTHS INJECTABLE CONTRACEPTIVE USERS

3-month injectable contraception is a hormonal contraceptive that is widely used by women of childbearing age (WUS) because it is very effective in preventing pregnancy, and includes the Intermediate-term Method. The use of 3-month injectable contraceptives also has drawbacks or side effects, one of which is menstrual cycle disorders. The purpose of this study was to determine the description of menstrual cycle disorders in users of 3-month injectable contraceptives.This study used a descriptive design. The population in this study was women of childbearing age who used injection contraception for 3 months at the sub-health center of Tanjung Village. The total population in this study was 48 samples. The sampling technique was carried out by the total sampling technique. The analytical method used in this study was descriptive statistics.The results of the study showed that using 3-month injectable contraceptives were found that 29 respondents (60.4%) experienced amenorrhea, 15 respondents (31.3%) spotting, and 4 respondents (8.3%) did not experience menstrual cycle disorders.Most users of 3-month injectable contraceptives experience amenorrhea