scholarly journals Advances into the Epigenetic Regulation by DNA Methylation in Non-Alcoholic Fatty Liver Disease

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Teresa Rubio- Tomás
Keyword(s):  
Dna Methylation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Epigenetic Regulation ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Abstract 5323: Gene-specific DNA methylation alterations in non-alcoholic fatty liver disease (NAFLD)-derived hepatocellular carcinoma in mice

2018 ◽  
Author(s):  
Barbara Borowa-Mazgaj ◽  
Aline de Conti ◽  
Mulugeta Seneshaw ◽  
Faridodin Mirshahi ◽  
Frederick A. Beland ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Identification of the genomic region under epigenetic regulation during non-alcoholic fatty liver disease progression

2017 ◽  
Vol 48 (3) ◽  
pp. E320-E334 ◽  
Author(s):  
Kikuko Hotta ◽  
Takuya Kitamoto ◽  
Aya Kitamoto ◽  
Yuji Ogawa ◽  
Yasushi Honda ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Disease Progression ◽  
Epigenetic Regulation ◽  
Fatty Liver Disease ◽  
Genomic Region ◽  
Alcoholic Fatty Liver ◽  
Liver Disease Progression ◽  
Alcoholic Fatty Liver Disease

scholarly journals Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression

2018 ◽  
Vol 51 (5) ◽  
pp. 2123-2135 ◽  
Author(s):  
Youlian Zhou ◽  
Tiying Zheng ◽  
Huiting Chen ◽  
Yongqiang Li ◽  
Hongli Huang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Liver Disease ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Serum Adiponectin ◽  
Promoter Regions ◽  
Alcoholic Fatty Liver ◽  
Probiotic Treatment ◽  
Alcoholic Fatty Liver Disease

Background/Aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD. Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. After 13 weeks of treatment, blood, liver, and cecal tissue samples were collected. Serum lipids, liver function indexes by biochemical analyzers, and changes in liver pathology with hematoxylin-eosin (HE) and masson staining were detected. Furthermore, the serum adiponectin by enzyme-linked immunosorbent assay (ELISA) and liver adiponectin methylation levels in the promoter regions by pyrophosphate sequencing were determined. High throughput Illumina sequencing targeted microbial 16S genes, bioinformatics and statistical analysis identified cecal-associated gut microbiota. Results: HFD with antibiotic exposure showed the most severe steatohepatitis and a severe gut microbiota alteration. Reduced bacterial diversity was also seen and the abundances of Firmicutes, Lactobacillus, Cyanobacteria, Acidobacteria, Chlamydiae, Chlamydiales, Rubrobacteria, Verrucomicrobia, Blautia, Shewanella, Bacteroides, Bacteroides acidifaciens, and Bacteroides uniformis, were shown to be partly reversed by probiotic treatment. Decreased serum adiponectin levels and increased DNA methylation levels of adiponectin promoter regions were also markedly associated with the NAFLD progression during gut microbiota alteration. Conclusion: Our results suggested that both gut microbiota alteration and adiponectin variability may be drivers of NAFLD progression and that targeting the gut microbiota, such as via administration of a probiotic, may delay NAFLD progression via adiponectin.

Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease

2013 ◽  
Vol 23 (6) ◽  
pp. 471-482 ◽  
Author(s):  
Yuan Tian ◽  
Vincent Wai-Sun Wong ◽  
Henry Lik-Yuen Chan ◽  
Alfred Sze-Lok Cheng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Fatty Liver ◽  
Epigenetic Regulation ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease

2016 ◽  
Vol 31 (9) ◽  
pp. 1646-1653 ◽  
Author(s):  
Naoshi Nishida ◽  
Norihisa Yada ◽  
Satoru Hagiwara ◽  
Toshiharu Sakurai ◽  
Masayuki Kitano ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Dna Damage ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Oxidative Dna Damage ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Newborn and childhood differential DNA methylation and liver fat in school-age children

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Madelon L. Geurtsen ◽  
Vincent W. V. Jaddoe ◽  
Lucas A. Salas ◽  
Susana Santos ◽  
Janine F. Felix
Keyword(s):  
Dna Methylation ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Liver Fat ◽  
School Age Children ◽  
Alcoholic Fatty Liver ◽  
Fat Accumulation ◽  
Fat Fraction ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease is the most common chronic liver disease in children in western countries. Adverse early-life exposures are associated with higher liver fat percentages in children. Differential DNA methylation may underlie these associations. We aimed to identify differential DNA methylation in newborns and children associated with liver fat accumulation in childhood. We also examined whether DNA methylation at 22 cytosine-phosphate-guanine sites (CpGs) associated with adult non-alcoholic fatty liver disease is associated with liver fat in children. Within a population-based prospective cohort study, we analyzed epigenome-wide DNA methylation data of 785 newborns and 344 10-year-old children in relation to liver fat fraction at 10 years. DNA methylation was measured using the Infinium HumanMethylation450 BeadChip (Illumina). We measured liver fat fraction by Magnetic Resonance Imaging. Associations of single CpG DNA methylation at the two-time points with liver fat accumulation were analyzed using robust linear regression models. We also analyzed differentially methylation regions using the dmrff package. We looked-up associations of 22 known adult CpGs at both ages with liver fat at 10 years. Results The median liver fat fraction was 2.0% (95% range 1.3, 5.1). No single CpGs and no differentially methylated regions were associated with liver fat accumulation. None of the 22 known adult CpGs were associated with liver fat in children. Conclusions DNA methylation at birth and in childhood was not associated with liver fat accumulation in 10-year-old children in this study. This may be due to modest sample sizes or DNA methylation changes being a consequence rather than a determinant of liver fat.

scholarly journals Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

Gut ◽  
2016 ◽  
Vol 66 (7) ◽  
pp. 1321-1328 ◽  
Author(s):  
Timothy Hardy ◽  
Mujdat Zeybel ◽  
Christopher P Day ◽  
Christian Dipper ◽  
Steven Masson ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Plasma Dna ◽  
Alcoholic Fatty Liver ◽  
Potential Biomarker ◽  
Alcoholic Fatty Liver Disease

scholarly journals The Co-occurrence of Chronic Hepatitis B and Fibrosis Is Associated With a Decrease in Hepatic Global DNA Methylation Levels in Patients With Non-alcoholic Fatty Liver Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
FangYuan Li ◽  
Qian Ou ◽  
ZhiWei Lai ◽  
LiuZhen Pu ◽  
XingYi Chen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis B ◽  
Fatty Liver ◽  
Chronic Hepatitis B ◽  
Fatty Liver Disease ◽  
Global Dna Methylation ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Global DNA hypomethylation has been reported in patients with chronic hepatitis B (CHB) and non-alcoholic fatty-liver disease (NAFLD). However, the global DNA methylation profile of patients with concurrent NAFLD and CHB (NAFLD + CHB) is still unclear. We aimed to detect the hepatic global DNA methylation levels of NAFLD + CHB patients and assess the associated risk factors. Liver biopsies were collected from 55 NAFLD patients with or without CHB. The histological characteristics of the biopsy were then assessed. Hepatic global DNA methylation levels were quantified by fluorometric method. The hepatic global DNA methylation levels in NAFLD + CHB group were significantly lower than that in NAFLD group. Participants with fibrosis showed lower levels of hepatic global DNA methylation than those without fibrosis. Participants with both CHB and fibrosis had lower levels of hepatic global DNA methylation than those without either CHB or fibrosis. The co-occurrence of CHB and fibrosis was significantly associated with a reduction in global DNA methylation levels compared to the absence of both CHB and fibrosis. Our study suggests that patients with NAFLD + CHB exhibited lower levels of global DNA methylation than patients who had NAFLD alone. The co-occurrence of CHB and liver fibrosis in NAFLD patients was associated with a decrease in global DNA methylation levels.

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