scholarly journals PROTECTIVE ROLE OF COMBINATION OF HERBAL EXTRACT AGAINST STREPTOZOTOCIN INDUCED IN VIVO ANTIOXIDANT ACTIVITY OF MALE WISTAR RATS

Biomarkers ◽  
2021 ◽  
pp. 1-15
Author(s):  
Akpotu E. Ajirioghene ◽  
Samuel I. Ghasi ◽  
Lawrence O. Ewhre ◽  
Olusegun G. Adebayo ◽  
Jerome N. Asiwe

Author(s):  
Eman I. Sobeh ◽  
Rehab Amin ◽  
H.M. Saleh ◽  
S.E. Ali ◽  
Souad A. ElFeky

2013 ◽  
Vol 4 (2) ◽  
pp. 414 ◽  
Author(s):  
AllaGopala Reddy ◽  
PentelaRavi Kumar ◽  
YerradoddiRamana Reddy ◽  
ThirthamMadava Rao ◽  
Chiluka Haritha ◽  
...  

Author(s):  
Ling Wang ◽  
Hongdi Lv ◽  
Guoqi Xie ◽  
Feng Su ◽  
Xiuli Geng ◽  
...  

Background: Stroke has been considered as the second leading cause of death worldwide. The survivors of stroke experience different level of impair brain function. In China, Chinese traditional medicine had been widely accepted for stroke therapy and prevention. In this study, we developed Traditional Chinese Medicine based Xinnaoning (peace of heart and brain) Tablet and tested its protective role for ischemic stroke in rat model. Material and Methods: Male Wistar rats (n=60) with 12 weeks old and weight from 180 to 200 gram were randomly divided to five groups (n=12). For the groups with Xinaoning administration, the drug was administrated to rats once per day for 7 consecutive days. The blood clotting time and the thrombus wet weight was measured. Serum samples were collected from each rat for further Measurement of biochemical indicators. Results: Our results demonstrated that Xinnaoning tablet reduced lactate acid (LD) level and increased lactic acid dehydrogenase (LDH) in cerebral ischemia model as well as reduced the infarct size caused by stroke. Besides, evaluation of the level of different ATPases suggested Xinnaoning tablet could modulate ATPases activity and confer a protective role in brain. Moreover, analysis indicated Xinnaoning tablet have the anti-coagulation effect in vivo which may contribute to the protection of ischemia. Conclusion: Our findings suggest that Xinnaoning tablet may be a potential way for cerebral ischemia prevention.


Author(s):  
Zafer Sahin ◽  
Ahmet Ozkaya ◽  
Okkes Yilmaz ◽  
Abdurrauf Yuce ◽  
Mehmet Gunes

AbstractBackground:We have investigated the effects of α-lipoic acid (LA), a powerful antioxidant, on the fatty acid (FA) profiles, aluminum accumulation, antioxidant activity and some minerals such as zinc, copper and iron against aluminum chloride (AlClMethods:Twenty-eight male Wistar rats were divided into four groups as control, LA, AlClResults:AlClConclusions:These results indicate that AlCl


2016 ◽  
Vol 174 (1) ◽  
pp. 112-120 ◽  
Author(s):  
Nasim Babaknejad ◽  
Ali Asghar Moshtaghie ◽  
Hashem Nayeri ◽  
Mohsen Hani ◽  
Somaye Bahrami

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