Investigation of the role of α-lipoic acid on fatty acids profile, some minerals (zinc, copper, iron) and antioxidant activity against aluminum-induced oxidative stress in the liver of male rats

2017 ◽  
Vol 28 (4) ◽  
Author(s):  
Zafer Sahin ◽  
Ahmet Ozkaya ◽  
Okkes Yilmaz ◽  
Abdurrauf Yuce ◽  
Mehmet Gunes
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Antioxidant Activity ◽  
Lipoic Acid ◽  
Wistar Rats ◽  
Male Rats ◽  
Fatty Acids Profile ◽  
Male Wistar Rats ◽  
Aluminum Accumulation

AbstractBackground:We have investigated the effects of α-lipoic acid (LA), a powerful antioxidant, on the fatty acid (FA) profiles, aluminum accumulation, antioxidant activity and some minerals such as zinc, copper and iron against aluminum chloride (AlClMethods:Twenty-eight male Wistar rats were divided into four groups as control, LA, AlClResults:AlClConclusions:These results indicate that AlCl

scholarly journals Chronic exposure of adult male Wistar rats to bisphenol A causes testicular oxidative stress: Role of gallic acid

2020 ◽  
Vol 54 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Samuel Gbadebo Olukole ◽  
Eunice Olufunke Ola-Davies ◽  
Damilare Olaniyi Lanipekun ◽  
Bankole Olusiji Oke
Keyword(s):  
Oxidative Stress ◽  
Bisphenol A ◽  
Gallic Acid ◽  
Adult Male ◽  
Chronic Exposure ◽  
Wistar Rats ◽  
The Body ◽  
Male Rats ◽  
Male Wistar Rats

AbstractObjectives. Bisphenol A (BPA) has been reported that among other male reproductive dys-functions, it can cause marked estrogenic effects including alteration in serum hormones as well as testicular lesions in exposed animals. This work sought to study the role of gallic acid (GA), a known antioxidant, on the BPA-induced testicular oxidative stress in adult male Wistar rats using serum hormone analysis, histopathology, and biochemical assays.Methods. Adult male rats were divided into four groups (n=10) including control (0.2 ml of corn oil), GA (20 mg/kg/day), BPA (10 mg/kg/day), BPA+GA (BPA, 10 mg/kg/day + GA, 20 mg/kg/day). All medications were given by oral gavage for 45 consecutive days. The body and testicular weights were measured. Blood and organ samples were collected for the serum hormonal assay: testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL), and tissue biochemistry analysis: superoxide dismutase (SOD), reduced glutathione (GSH), glutathione-S-transferase (GST), malondialdehyde (MDA), hydrogen peroxide (H2O2), respectively.Results. The BPA-treated rats showed significant reduction in the gonadosomatic index. BPA also caused significant decrease in the levels of the serum testosterone and prolactin. Furthermore, BPA induced testicular oxidative stress by decreasing the activities of antioxidant enzymes and increasing reactive oxygen species. However, co-treatment with GA protected against these alterations.Conclusion. Findings from the present study confirmed the previously reported data and show that the ability of GA, as a potent antioxidant, may protect against BPA-induced alterations in the male reproductive function. Hence, GA protects against testicular oxidative stress in adult male Wistar rats following chronic exposure to BPA.

Curcumin prevents inflammatory response, oxidative stress and insulin resistance in high fructose fed male Wistar rats: Potential role of serine kinases

2016 ◽  
Vol 244 ◽  
pp. 187-194 ◽  
Author(s):  
Nachimuthu Maithilikarpagaselvi ◽  
Magadi Gopalakrishna Sridhar ◽  
Rathinam Palamalai Swaminathan ◽  
Bobby Zachariah
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Inflammatory Response ◽  
Wistar Rats ◽  
Potential Role ◽  
High Fructose ◽  
Male Wistar Rats ◽  
Serine Kinases

Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress

2016 ◽  
Vol 94 (10) ◽  
pp. 1074-1082 ◽  
Author(s):  
Dragan Hrncic ◽  
Jelena Mikić ◽  
Aleksandra Rasic-Markovic ◽  
Milica Velimirović ◽  
Tihomir Stojković ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Open Field ◽  
Wistar Rats ◽  
Brain Regions ◽  
Oxidative Status ◽  
Standard Diet ◽  
Male Wistar Rats ◽  
Brain Oxidative Stress ◽  
The Brain

The aim of this study was to examine the effects of a methionine-enriched diet on anxiety-related behavior in rats and to determine the role of the brain oxidative status in these alterations. Adult male Wistar rats were fed from the 30th to 60th postnatal day with standard or methionine-enriched diet (double content comparing with standard diet: 7.7 g/kg). Rats were tested in open field and light–dark tests and afterwards oxidative status in the different brain regions were determined. Hyperhomocysteinemia induced by methionine-enriched diet in this study decreased the number of rearings, as well as the time that these animals spent in the center of the open field, but increased index of thigmotaxy. Oxidative status was selectively altered in the examined regions. Lipid peroxidation was significantly increased in the cortex and nc. caudatus of rats developing hyperhomocysteinemia, but unaltered in the hippocampus and thalamus. Based on the results of this research, it could be concluded that hyperhomocysteinemia induced by methionine nutritional overload increased anxiety-related behavior in rats. These proanxiogenic effects could be, at least in part, a consequence of oxidative stress in the rat brain.

scholarly journals Effects of Licorice (Glycyrrhiza glabra) on testicular oxidative stress in sleep-deprived male Wistar rats

2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Ayodeji J Ajibare ◽  
Olabode O Akintoye ◽  
Oyesanmi A Fabunmi ◽  
Luqman A Olayak ◽  
Babatunde A Olofinbiyi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Medicinal Plant ◽  
Sleep Deprivation ◽  
Wistar Rats ◽  
Glycyrrhiza Glabra ◽  
Simultaneous Increase ◽  
Distilled Water ◽  
Stress Injury ◽  
Male Wistar Rats

Background: Sleep deprivation is a public health problem that causes oxidative stress injury. Research evidence agrees that oxidative stress serves as an underlying factor in many chronic debilitating diseases. This study investigated the effect of aqueous Licorice extract (Glycyrrhiza glabra) a medicinal plant with known antioxidant activity on testicular oxidative stress parameters. Methods Twenty-five male Wistar rats were randomly allocated to and administered one of the following treatment regimens daily for five days: CONTROL – Distilled water, Sleep – Deprived (SD) – Distilled water, Sleep Deprived +Sleep Recovery (SD+SR) – Distilled Water, SD+LICORICE (SD+LICORICE) – 150 mg/kg bodyweight of Licorice and Sleep – Deprivation + Sleep-Recovery + Licorice (SD+SR+LICORICE) – 150 mg/kg bodyweight of Licorice. The rats in Sleep – Recovery groups were allowed to sleep in their cages after sleep deprivation protocol for 5 days each treatment regimen had ad libitum access to standard rat chow. After the experiment, the rats were sacrificed and blood was collected. Serum cortisol and testosterone were taken alongside testicular Glutathione, Catalase, and Malondialdehyde. Results Sleep deprivation significantly raised cortisol level and decreased testosterone levels both of which were reversed by licorice administration. Significant reduction in Malondialdehyde (MDA) in rats treated with licorice with a simultaneous increase in both GSH and CAT was also observed. Conclusions The antioxidant activity of licorice (Glycyrrhiza glabra) aqueous extract on the testis of rats exposed to oxidative stress suggests the potential of using this traditional medicinal plant in preventing oxidative injury caused by sleep deprivation.

Polychlorinated biphenyl (PCBs)-induced oxidative stress plays a role on vertebral antioxidant system: Ameliorative role of vitamin C and E in male Wistar rats

2014 ◽  
Vol 4 (3) ◽  
pp. 411-416
Author(s):  
Subramanian Karthikeyan ◽  
Muthusamy Sridhar ◽  
Govindan Ramajayam ◽  
Ramadoss Lavanya ◽  
Jagadeesan Arunakaran ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Antioxidant System ◽  
Wistar Rats ◽  
Polychlorinated Biphenyl ◽  
Male Wistar Rats

scholarly journals Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1999
Author(s):  
Lidia V. Kravchenko ◽  
Ilya V. Aksenov ◽  
Nikolay S. Nikitin ◽  
Galina V. Guseva ◽  
Ludmila I. Avrenyeva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Liver Disease ◽  
Lipoic Acid ◽  
Lipid Accumulation ◽  
Wistar Rats ◽  
Weight Ratio ◽  
Body Weight Ratio ◽  
Deficient Diet ◽  
Male Wistar Rats

Non-alcoholic fatty liver disease (NAFLD) is currently estimated as the most prevalent chronic liver disease in all age groups. An increasing body of evidence obtained in experimental and clinical data indicates that oxidative stress is the most important pathogenic factor in the development of NAFLD. The study aimed to investigate the impact of α-lipoic acid (LA), widely used as an antioxidant, on the effects of a hypercaloric choline-deficient diet. Male Wistar rats were divided into three groups: control diet (C); hypercaloric choline-deficient diet (HCCD), and hypercaloric choline-deficient diet with α-lipoic acid (HCCD+LA). Supplementation of HCCD with LA for eight weeks led to a decrease in visceral adipose tissue/body weight ratio, the activity of liver glutathione peroxidase and paraoxonase-1, plasma, and liver total antioxidant activity, as well as an increase in liver/body weight ratio, liver total lipid and triglyceride content, and liver transaminase activities compared to the HCCD group without LA. In conclusion, our study shows that α-lipoic acid detains obesity development but exacerbates the severity of diet-induced oxidative stress and lipid accumulation in the liver of male Wistar rats fed a hypercaloric choline-deficient diet.

scholarly journals Testicular cytoprotective activities of Curcuma longa in STZ-induced diabetic adult male wistar rats

1970 ◽  
Vol 6 (1) ◽  
pp. 905-913
Author(s):  
A.J Olanrewaju ◽  
J.O. Owolabi ◽  
S.Y. Olatunji ◽  
A.B.O. Desalu ◽  
W.C. Amaechi
Keyword(s):  
Oxidative Stress ◽  
Leydig Cells ◽  
Wistar Rats ◽  
Curcuma Longa ◽  
Chow Group ◽  
Reproductive Age ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Histological Structure ◽  
Male Wistar Rats

This study was aimed at investigating the cytoprotective activities of Curcuma longa (Turmeric) on the histological structure of the testes in diabetic male rats. Turmeric is commonly called the golden spice, is used as a spice in cooking and also has a long history of medicinal use, dating back nearly 4000 years to the Vedic culture in India. Its major component is the curcumin that is found to be a natural antioxidant. Diabetes affects large number of young men of reproductive age. It is among a number of disorders associated with oxidative stress. There has been a relationship established between the reduction in glucose load and insulin resistance reduction and oxidative stress in people. Male wistar rats (n=24) were allocated randomly into six groups, 4 in each. Group 1: Control were given only water and standard rat chow; Group 2 and 3: turmeric (100mg/kg) and (25mg/kg) respectively; Group 4: induced with 30mg/kg of streptozotocin (STZ) for 3 days; Group 5: STZ with turmeric (100mg/kg); Group 6: STZ with turmeric (25mg/kg). At the end of the experiment (21 days), the testes were excised for histological analysis. The seminiferous tubules, seminiferous epithelium, Leydig cells were shown to be enhanced in the histoarchitecture of the testes of the treated diabetic groups and did not show any toxicity on the testes in the non-diabetic groups. In conclusion, this study has shown that turmeric does not only possess a non-toxic effect but has cytoprotective effects on the histoarchitecture of the testes in diabetic rats.Keywords: histo-architecture, leydig cells, diabetes, oxidative stress, testes, curcumin.

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