scholarly journals Reaching a Meaningful Agreement among Diverse Parties: The Potential Contribution of Mind Genomics to an Iterated, Optimal Policy

2021 ◽  
Vol 3 (4) ◽  
1988 ◽  
Vol 43 (4) ◽  
pp. 318-321 ◽  
Author(s):  
Michael D. Intriligator ◽  
Dagobert L. Brito

2016 ◽  
Vol 55 (02) ◽  
pp. 51-62 ◽  
Author(s):  
S. Hermann ◽  
M. Schäfers ◽  
C. Höltke ◽  
A. Faust

SummaryOptical imaging has long been considered a method for histological or microscopic investigations. Over the last 15 years, however, this method was applied for preclinical molecular imaging and, just recently, was also able to show its principal potential for clinical applications (e.g. fluorescence-guided surgery). Reviewing the development and preclinical evaluation of new fluorescent dyes and target-specific dye conjugates, these often show characteristic patterns of their routes of excretion and biodistribution, which could also be interesting for the development and optimization of radiopharmaceuticals. Especially ionic charges show a great influence on biodistribution and netcharge and charge-distribution on a conjugate often determines unspecific binding or background signals in liver, kidney or intestine, and other organs.Learning from fluorescent probe behaviour in vivo and translating this knowledge to radio-pharmaceuticals might be useful to further optimize emerging and existing radiopharmaceuticals with respect to their biodistribution and thereby availability for binding to their targets.


2014 ◽  
Vol 4 (3) ◽  
pp. 30-35
Author(s):  
Catherine Cummins ◽  
◽  
Mohan Kumaratne ◽  
Erlyana . ◽  
Loucine Huckabay ◽  
...  

2018 ◽  
Vol 11 (1) ◽  
pp. 130-149 ◽  
Author(s):  
Osman Jussah ◽  
Mohamed O. M. Orabi ◽  
Janez Sušnik ◽  
Françoise Bichai ◽  
Chris Zevenbergen

Abstract Growing water demand poses a challenge for supply. Poor understanding of alternative sources can hamper plans for addressing water scarcity and supply resilience. The potential of three alternative supply systems in Lilongwe, Malawi and Sharm El-Sheikh, Egypt are compared using a fast, data-light assessment approach. Lilongwe water supply is based on unsustainable use of source water, while Sharm depends primarily on desalination. Both locations experience shortages due to poor system performance and service inequity. Alternative supply systems are shown to potentially contribute to supply augmentation/diversification, improving service and system resilience. There are considerable seasonal variations to consider, especially regarding storage of water. Social preferences could limit the uptake/demand for alternative water. One important conclusion is the value in addressing public perceptions of alternative systems, and assessing water end use in order to site systems appropriately. Other issues surround financing, encouraging uptake and addressing institutional/governance aspects surrounding equitable distribution. A further consideration is whether demand reductions might yield shorter-term improvements in performance without the need to institute potentially expensive alternative water strategies. Reducing non-revenue water is a priority. Such measures should be undertaken with alternative supply enhancement to reduce inequity of supply, improve system performance and increase resilience to future changes.


1996 ◽  
Vol 31 (3) ◽  
pp. 485-504 ◽  
Author(s):  
Patricia Chow-Fraser ◽  
Barb Crosbie ◽  
Douglas Bryant ◽  
Brian McCarry

Abstract During the summer of 1994, we compared the physical and nutrient characteristics of the three main tributaries of Cootes Paradise: Spencer, Chedoke and Borer’s creeks. On all sampling occasions, concentrations of CHL α and nutrients were always lowest in Borer’s Creek and highest in Chedoke Creek. There were generally 10-fold higher CHL α concentrations and 2 to 10 times higher levels of nitrogen and phosphorus in Chedoke Creek compared with Spencer Creek. Despite this, the light environment did not differ significantly between Spencer and Chedoke creeks because the low algal biomass in Spencer Creek was balanced by a relatively high loading of inorganic sediments from the watershed. Laboratory experiments indicated that sediments from Chedoke Creek released up to 10 µg/g of soluble phosphorus per gram (dry weight) of sediment, compared with only 2 µg/g from Spencer Creek. By contrast, sediment samples from Spencer Creek contained levels of polycyclic aromatic hydrocarbon that were as high as or higher than those from Chedoke Creek, and much higher than those found in Borer’s Creek. The distribution of normalized PAH concentrations suggests a common source of PAHs in all three tributaries, most likely automobile exhaust, since there were high concentrations of fluoranthene and pyrene, both of which are derivatives of engine combustion.


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