scholarly journals Green Synthesis of Uracil Derivatives, DNA Binding Study and Docking-based Evaluation of their Anti-cancer and Anti-viral Potencies

2022 ◽  
pp. 116-133
Author(s):  
Vadivelan Rengasamy ◽  
Mohd Suhail ◽  
Arvind Jain
Keyword(s):  
Dna Binding ◽  
Green Synthesis ◽  
Binding Study ◽  
Uracil Derivatives ◽  
Anti Cancer

Chiral halogenated Schiff base compounds: green synthesis, anticancer activity and DNA-binding study

2018 ◽  
Vol 1161 ◽  
pp. 497-511 ◽  
Author(s):  
Mahnaz Ariyaeifar ◽  
Hadi Amiri Rudbari ◽  
Mehdi Sahihi ◽  
Zahra Kazemi ◽  
Abolghasem Abbasi Kajani ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Green Synthesis ◽  
Anticancer Activity ◽  
Binding Study

Water-soluble copper(II) complexes with 4,5-dichloro-isothiazole-3-carboxylic acid and heterocyclic N-donor ligands: Synthesis, crystal structures, cytotoxicity, and DNA binding study

2020 ◽  
Vol 510 ◽  
pp. 119778 ◽  
Author(s):  
Julia A. Eremina ◽  
Elizaveta V. Lider ◽  
Taisiya S. Sukhikh ◽  
Lyubov S. Klyushova ◽  
Maria L. Perepechaeva ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Dna Binding ◽  
Crystal Structures ◽  
Water Soluble ◽  
Binding Study ◽  
Donor Ligands

scholarly journals Green synthesis, characterization and anti-cancer capability of Co0.5Ni0.5Nd0.02Fe1.98O4 nanocomposites

2021 ◽  
pp. 103564
Author(s):  
M.A. Almessiere ◽  
F.A. Khan ◽  
I.A. Auwal ◽  
M. Sertkol ◽  
N. Tashkandi ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Anti Cancer

DNA-binding, photocleavage and anti-cancer activity of tin(IV) corrole

2018 ◽  
Vol 22 (09n10) ◽  
pp. 739-750 ◽  
Author(s):  
An-Na Xie ◽  
Zhao Zhang ◽  
Hua-Hua Wang ◽  
Atif Ali ◽  
Dong-Xu Zhang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Calf Thymus Dna ◽  
Free Base ◽  
Docking Analysis ◽  
Calf Thymus ◽  
Anti Cancer ◽  
Active Intermediate ◽  
Dna Scission ◽  
Cancer Activity

A new tin(IV) corrole, 5,10,15-tris(4-methoxycarbonylphenyl) corrole tin(IV) (1-Sn) was synthesized and characterized. The DNA binding, photocleavage and anti-cancer activity were studied and compared with its free-base. The interaction of 1-Sn and its free-base 1 with calf thymus DNA had been investigated by spectroscopic methods, viscosity measurements and molecular docking analysis. The results revealed that 1-Sn and 1 could interact with calf thymus DNA via an outside groove binding mode. Furthermore, although 1 displayed no photonuclease activity, 1-Sn exhibited good photonuclease activity as indicated by agarose gel electrophoresis, and superoxide anion might be the active intermediate for the DNA scission. Finally, 1 was nontoxic but 1-Sn displayed cytotoxicity towards A549 tumor cell lines.

Two DNA binding modes of a zinc-metronidazole and biological evaluation as a potent anti-cancer agent

2019 ◽  
Vol 38 (7) ◽  
pp. 449-480 ◽  
Author(s):  
Farhad Ahmadi ◽  
Nosaibeh Shabrandi ◽  
Leilah Hosseinzadeh ◽  
Homa Azizian
Keyword(s):  
Dna Binding ◽  
Biological Evaluation ◽  
Binding Modes ◽  
Anti Cancer ◽  
Cancer Agent

Synthesis, characterization, X-ray structure and DNA binding study of palladium(II) complex with new thioether containing ONS donor ligand

2020 ◽  
Vol 132 (1) ◽  
Author(s):  
SUBRATA JANA ◽  
RAHUL NASKAR ◽  
CHANDAN KUMAR MANNA ◽  
TAPAN KUMAR MONDAL
Keyword(s):  
Dna Binding ◽  
Binding Study ◽  
Donor Ligand ◽  
X Ray

Development of oxopyrrolidine-based anti-cancer compounds: DNA binding, in silico, cell line studies, drug-likeness and mechanism at supra-molecular level

2014 ◽  
Vol 68 (4) ◽  
Author(s):  
Imran Ali ◽  
Waseem Wani ◽  
Kishwar Saleem ◽  
Ming-Fa Hsieh
Keyword(s):  
Dna Binding ◽  
In Silico ◽  
Binding Constants ◽  
Sodium Hydride ◽  
Nitrogen Atmosphere ◽  
In Silico Studies ◽  
Anti Cancer ◽  
Increasing Demand ◽  
Good Oral Bioavailability ◽  
Mcf 7

AbstractDue to an increasing demand for effective anti-cancer drugs, an oxopyrrolidine-based ligand, sodium 1-(3-(2-aminoethylamino)propyl)-5-oxopyrrolidine-2-carboxylate, was synthesised by the sodium hydride-assisted coupling of pyroglutamic acid with 1,3-diiodopropane under a nitrogen atmosphere. The intermediate thus formed was allowed to react with ethylenediamine in acetonitrile. The ligand formed individual complexes with Cu(II) and Ni(II) metal ions, respectively. The complexes were relatively resistant to degradation in PBS at physiological pH. The DNA-binding constants (K b) for the ligand, copper and nickel complexes were 2.09 × 104 M-1, 2.37 × 104 M-1 and 2.11 × 104 M-1, respectively, revealing the strong binding of these complexes with DNA. Haemolysis assays indicated that the ligand and its complexes were less toxic to rabbit RBCs than doxorubicin. Lipinski’s parameters calculated for the reported compounds indicated their good oral bioavailability. All the compounds exhibited good activities towards MCF-7 (wild type) cancer cell lines. The results of in silico studies, DNA-binding and anti-cancer activities indicated that the reported compounds might be interacting with DNA as one of their possible mechanisms of action.

6-Hydroxy Derivative as New Desfluoroquinolone (DFQ): Synthesis and DNA-Binding Study

2000 ◽  
Vol 19 (8) ◽  
pp. 1327-1336 ◽  
Author(s):  
Oriana Tabarrini ◽  
Claudia Sissi ◽  
Arnaldo Fravolini ◽  
Manlio Palumbo
Keyword(s):  
Dna Binding ◽  
Binding Study ◽  
Hydroxy Derivative
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