Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study

This report presents the case of a woman aged 40 who has experienced premature menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian injection of autologous platelet-rich plasma with the aim to rejuvenate the ovarian tissue and enable the employment of her own gametes through in-vitro fertilization. Six weeks following the autologous platelet-rich plasma treatment, a significant reduction in the patient’s follicle-stimulating hormone (FSH) levels were noted. A natural in-vitro fertilization cycle led to a biochemical pregnancy, resulting in a spontaneous abortion at the 5th week of pregnancy. This is the first report of a successful autologous platelet-rich plasma application leading to pregnancy in menopause. This report uniquely contributes to the medical knowledge and challenges current practice in the context of infertility. The efficiency and safety of this treatment with regard to the reproductive system merits further investigation.

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Regenerative Effect of Intraovarian Injection of Activated Autologous Platelet Rich Plasma: Serum Anti-Mullerian Hormone Levels Measured Among Poor-Prognosis In Vitro Fertilization Patients

International Journal of Regenerative Medicine ◽

10.31487/j.rgm.2020.01.02 ◽

2020 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

E. Scott Sills ◽

J. L. Petersen ◽

N. S. Rickers ◽

Samuel H. Wood ◽

...

Keyword(s):

Clinical Trial ◽

In Vitro Fertilization ◽

Platelet Rich Plasma ◽

Ovarian Tissue ◽

Ovarian Response ◽

Vitro Fertilization ◽

Autologous Platelet Rich Plasma ◽

Pre Treatment ◽

Autologous Platelet

This registered, prospective clinical trial assessed serum anti-Mullerian hormone (AMH) patterns after treatment with activated platelet rich plasma (PRP). Patients with low ovarian reserve and/or at least 1 prior failed in vitro fertilization (IVF) cycle (n=182) received PRP injected into ovarian tissue under ultrasound guidance. Pretreatment AMH, BMI and platelet (PLT) concentration were recorded and serum AMH, follicle stimulating hormone, and estradiol were then measured at 2-week intervals for up to three months. Mean±SD patient age was 45.4±6.1yrs. Improved serum AMH was observed in 51 patients (28%) with median increase of 167% [95%CI 91; 280] after treatment; mean interval to maximum AMH increase was 4 weeks (range 2-10 weeks). Improved post-treatment AMH was not limited to younger patients; when stratified by age (<42 vs. ≥42yrs), significant AMH improvements were seen in both groups after treatment (p=0.03 and 0.009, respectively). Among responders, mean basal PLT count was higher (274K) vs. non-responders (250K); p<0.001. This is the first clinical trial to describe an intraovarian PRP technique for low reserve and finds the treatment safe and associated with significant increases in serum AMH for some patients, usually within four weeks. The substantially different pre-treatment PLT concentrations measured across PRP response groups warrants further investigation. Additional research can characterize ovarian response better, optimize PRP protocols, and collect outcomes data from those who subsequently undergo IVF with autologous oocytes.

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Improved in vitro fertilization success and pregnancy outcome with autologous platelet-rich plasma treatment in unexplained infertility patients that had repeated implantation failure history

Gynecological Endocrinology ◽

10.1080/09513590.2019.1597344 ◽

2019 ◽

Vol 35 (9) ◽

pp. 815-818 ◽

Cited By ~ 7

Author(s):

Hakan Coksuer ◽

Yesim Akdemir ◽

Mert Ulas Barut

Keyword(s):

In Vitro Fertilization ◽

Platelet Rich Plasma ◽

Fertilization Success ◽

Unexplained Infertility ◽

Implantation Failure ◽

Vitro Fertilization ◽

Autologous Platelet Rich Plasma ◽

Infertility Patients ◽

Autologous Platelet

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Effectiveness of Intrauterine Infusion of Autologous Platelet-Rich Plasma in the Treatment of Thin Endometrium of Infertile Women

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i60a34513 ◽

2021 ◽

pp. 521-526

Author(s):

Namrata Choudhary ◽

Akash More ◽

Roshankumar Jha ◽

Ashish P. Anjankar

Keyword(s):

In Vitro Fertilization ◽

Endometrial Thickness ◽

Platelet Rich Plasma ◽

Thin Endometrium ◽

Vitro Fertilization ◽

Infertile Women ◽

Female Patients ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

One of the key factors in implantation and pregnancy is endometrium. Sufficiently great percentage of in vitro fertilization failure is because of the endometrial receptivity therefore, high quality embryo and adequate receptive endometrial growth are important for successful implantation. Platelet rich plasma has beneficial effect in advancement of endometrial thickness for women with thin endometrial thickness. PRP can be used in various medical conditions including patients with refractory endometrium as a complementary therapy to conventional treatment. Aim: To determine the effectiveness of intrauterine infusion of autologous platelet-rich plasma in the treatment of thin endometrium of infertile women. Objectives: To identify infertile female patients with inadequate endometrial growth (less than 7 mm) in the past frozen embryo transfer (FET) cycles despite standard treatments. To observe intrauterine infusion of autologous platelet-rich plasma (PRP) in these infertile female patients with thin endometrium. To determine the effectiveness of intrauterine infusion of autologous PRP in the treatment of thin endometrium of infertile women during In vitro fertilization (IVF). Methods: It is a prospective observational study. Present study will be carried out with 30 patients. Women having inappropriate endometrial thickness of less than 7 mm, in past FET cycles will be included. Sonographic machine will be used; to measure endometrial thickness by an expert Gynecologist, where thickest part of uterus will be measured in longitudinal axis. Expected Results: It is expected that intra uterine infusion of PRP will be effective in thickening of endometrial wall in patients with thin endometrium. Once the results are satisfactory it can be helpful for endometrial preparation in reproduction techniques. Conclusion: Present study is purposed to testify PRP as a novel method for advancement of reproductive medicine, it will be helpful to overcome with the issues such as inadequate thickness of endometrium, poor response to conventional therapy and increase clinical pregnancies and live births positively.

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