Premalignant epithelial disorders of the vulva: squamous vulvar intraepithelial neoplasia, vulvar Paget's disease and melanoma in situ

2010 ◽  
Vol 89 (6) ◽  
pp. 741-748 ◽  
Author(s):  
Annelinde Terlou ◽  
Leen J. Blok ◽  
Theo J.M. Helmerhorst ◽  
Marc van Beurden
Keyword(s):  
Paget’S Disease ◽  
Intraepithelial Neoplasia ◽  
Paget's Disease ◽  
Vulvar Intraepithelial Neoplasia ◽  
Melanoma In Situ ◽  
Vulvar Paget’S Disease

Melanoma In Situ Versus Paget’s Disease

2014 ◽  
pp. 133-143
Author(s):  
Jon A. Reed ◽  
Christopher R. Shea ◽  
Victor G. Prieto
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Melanoma In Situ

Pigmented Paget's disease of the nipple mistaken for melanoma in situ : a diagnostic pitfall for the unwary

Pathology ◽  
2018 ◽  
Vol 50 (3) ◽  
pp. 364-367 ◽  
Author(s):  
Annalisa Solinas ◽  
Annabelle Mahar ◽  
Wendy A. Cooper ◽  
John F. Thompson ◽  
Andrew J. Spillane ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Diagnostic Pitfall ◽  
Melanoma In Situ

scholarly journals A case of recurrent vulvar Paget's disease difficult to differentiate from in situ spread of transitional cell carcinoma.

1999 ◽  
Vol 38 (2) ◽  
pp. 183-186
Author(s):  
Mitsuhiro NOKUBI ◽  
Yoshio SUZUKI ◽  
Yoshishige SATO ◽  
Mitsuo HAYASHI ◽  
Takehiro OIKAWA ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Vulvar Paget’S Disease

Thirty Year Old Female Presented with Nipple Destruction: A Case Report

2019 ◽  
Vol 11 (1) ◽  
pp. 81-83
Author(s):  
Md Mustafizur Rahman ◽  
Nadim Ahmed ◽  
Sami Ahmad ◽  
Shoaeb Imtiaz Alam ◽  
Mohammad Rashedul Hassan ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Paget’S Disease ◽  
Radical Mastectomy ◽  
Paget's Disease ◽  
College Hospital ◽  
Rare Type ◽  
Medical College ◽  
Ductal Cell ◽  
Areola Complex

Paget’s disease of the breast is a rare type of cancer of the nipple–areola complex and that is often associated with an underlying in situ or invasive carcinoma. It is often misdiagnosed as eczema of breast and treatment is delayed. Here we present a case where a 30 year old female presented with itching ulceration and destruction of her left nipple. She was treated initially by local physicians by applying local ointments but as her condition did not improve she was admitted to department of surgery Shaheed Suhrawardy Medical College hospital where she was diagnosed as Paget’s disease with infiltrating ductal cell carcinoma. She underwent modified radical mastectomy with axillary clearance and referred to oncology department for further management. J Shaheed Suhrawardy Med Coll, June 2019, Vol.11(1); 81-83

Not All Cases of Mammary Paget’s Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!

2021 ◽  
pp. 106689692110029
Author(s):  
Kerschen Anja ◽  
Dano Hélène ◽  
Van Eeckhout Pascal ◽  
Marot Liliane ◽  
Van Bockstal Mieke
Keyword(s):  
Present Report ◽  
Paget’S Disease ◽  
Growth Factor Receptor ◽  
Punch Biopsy ◽  
Paget's Disease ◽  
Cytokeratin 7 ◽  
In Situ Carcinoma ◽  
Epidermal Growth ◽  
Mammary Paget’S Disease

Mammary Paget’s disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resulted in an initial misdiagnosis and, subsequently, a delay in the patient's follow-up. Additional immunohistochemistry for GATA binding protein 3 (GATA3) and human epidermal growth factor receptor 2 (HER2), as well as a second opinion of a breast pathologist, resulted in the diagnosis of mammary Paget's disease. The aim of this article is to raise awareness among pathologists and prevent them from misdiagnosing CK7-negative Paget disease of the breast.

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