Thirty Year Old Female Presented with Nipple Destruction: A Case Report

2019 ◽  
Vol 11 (1) ◽  
pp. 81-83
Author(s):  
Md Mustafizur Rahman ◽  
Nadim Ahmed ◽  
Sami Ahmad ◽  
Shoaeb Imtiaz Alam ◽  
Mohammad Rashedul Hassan ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Paget’S Disease ◽  
Radical Mastectomy ◽  
Paget's Disease ◽  
College Hospital ◽  
Rare Type ◽  
Medical College ◽  
Ductal Cell ◽  
Areola Complex

Paget’s disease of the breast is a rare type of cancer of the nipple–areola complex and that is often associated with an underlying in situ or invasive carcinoma. It is often misdiagnosed as eczema of breast and treatment is delayed. Here we present a case where a 30 year old female presented with itching ulceration and destruction of her left nipple. She was treated initially by local physicians by applying local ointments but as her condition did not improve she was admitted to department of surgery Shaheed Suhrawardy Medical College hospital where she was diagnosed as Paget’s disease with infiltrating ductal cell carcinoma. She underwent modified radical mastectomy with axillary clearance and referred to oncology department for further management. J Shaheed Suhrawardy Med Coll, June 2019, Vol.11(1); 81-83

scholarly journals Practical consensus recommendatons for Paget’s disease in breast cancer

2018 ◽  
Vol 07 (02) ◽  
pp. 083-086 ◽  
Author(s):  
A. Gaurav ◽  
V. Gupta ◽  
R. Koul ◽  
S. Dabas ◽  
R. Sareen ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Treatment Options ◽  
Paget’S Disease ◽  
Practical Experience ◽  
Disease Diagnosis ◽  
Paget's Disease ◽  
Expert Group ◽  
Rare Type ◽  
Areola Complex

AbstractPaget's disease of the breast is a rare type of cancer of the nipple–areola complex and that is often associated with an underlying in situ or invasive carcinoma. Diagnosis and treatment of Paget's disease is controversial. Expert oncologists discuss on the update on the approaches of Paget's disease diagnosis and its treatment options. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.

scholarly journals Paget’s disease of the breast: a case series

2020 ◽  
Vol 7 (8) ◽  
pp. 2706
Author(s):  
Solomon N. Elenwo ◽  
Rollings S. Jamabo
Keyword(s):  
Invasive Carcinoma ◽  
Paget’S Disease ◽  
Case Series ◽  
Radical Mastectomy ◽  
Paget's Disease ◽  
Histological Findings ◽  
Modified Radical Mastectomy ◽  
Modes Of Presentation ◽  
Simple Mastectomy

Paget’s disease of the nipple is a rare disease with a rather bizarre presentation which makes the diagnosis easily missed. Three cases are presented here with different modes of presentation and histological findings. A biopsy provided the definitive diagnosis in the three patients and the treatments offered was based on the histological findings - modified radical mastectomy and simple mastectomy for invasive carcinoma and carcinoma in-situ respectively.

Practical approach to extensive cutaneous spread without any underlying malignancy: a rare presentation of Paget’s disease of breast

2020 ◽  
Vol 13 (4) ◽  
pp. e233600
Author(s):  
Kamal Kishore Lakhera ◽  
Sanjeev Patni ◽  
Nidhi Patni ◽  
Rohit Jindal
Keyword(s):  
Abdominal Wall ◽  
Invasive Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Breast Pathology ◽  
Rare Presentation ◽  
Breast Parenchyma ◽  
Areola Complex ◽  
Underlying Malignancy

Paget’s disease of the breast is a rare intraepithelial malignancy involving the nipple–areola complex, often associated with an underlying in-situ or invasive carcinoma in the breast parenchyma. Most of the cases disease is usually limited to nipple–areola or surrounding periareolar skin. We are reporting a case of extensive Paget’s disease, involving entire breast skin and even part of abdominal wall skin without any underlining breast pathology, which is a rare presentation.

scholarly journals Paget’s disease of breast with an unusual presentation of involvement of overlying skin of breast: a case report

2020 ◽  
Vol 7 (12) ◽  
pp. 4231
Author(s):  
Pravin Kumar ◽  
Arpita Jindal ◽  
Bhushan Bhalgat ◽  
Phanindra Kumar Swain ◽  
Raj Govind Sharma
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Rare Type ◽  
Areola Complex ◽  
Mammary Paget’S Disease ◽  
Surrounding Skin

Paget’s disease of breast is also known as Paget’s disease of the nipple & mammary Paget’s disease, involving the skin of nipple & areola. It is rare type of cancer with tumors inside the same breast which may be either ductal carcinoma in-situ or invasive breast cancer. We report a case with Paget’s disease of breast which is not only involving the nipple-areola complex but also involving surrounding skin of breast.

Paget’s Disease of the Breast and Our Clinical Experience at Ain Shams University Hospitals

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ashraf abd el Moghny Mostafa ◽  
Karim Fahmy abd el Moaty ◽  
Paula Samir Nazim Sadary
Keyword(s):  
Breast Cancer ◽  
Paget’S Disease ◽  
Radical Mastectomy ◽  
Paget's Disease ◽  
Treatment Modalities ◽  
Pathological Features ◽  
University Hospitals ◽  
Simple Mastectomy ◽  
Delays In Diagnosis

Abstract Background Worldwide, breast cancer comprises 10.4% of all cancer incidences among women, making it the second most common type of non-skin cancer (after lung cancer) and the fifth most common cause of cancer death. In 2004, breast cancer caused 519,000 deaths worldwide (7% of cancer deaths; almost 1% of all deaths). Breast cancer is about 100 times more common in women than in men, although males tend to have poorer outcomes due to delays in diagnosis. Aim of the Work To clarify clinical, pathological features and outcomes of the treatment modalities for Paget’s disease of the breast at Ain Shams University Hospitals. Materials and Methods Our study was held as a retrospective cohort study to clarify clinical, pathological features and outcomes of the treatment modalities for Paget’s disease of the breast at Ain Shams University Hospitals. Results At Ain Shams university hospitals patients having pagetoid cells by biopsy and no mass radiologically underwent simple mastectomy and if pathology proved any malignancy in breast tissue axillary clearance was done and might be followed by radiotherapy. Conclusion Patients having pagetoid cells by biopsy and a mass radiologically which is invasive or insitu with microinvasion will undergo modified radical mastectomy and may be followed by radiotherapy. But if pagetoid cells and mass radiologically which is in situ simple mastectomy will be done.

Outcome of Percutaneous Nephrostomy in Children With Ureteropelvic Junction Obstruction

2020 ◽  
Vol 20 (2) ◽  
pp. 61-64
Author(s):  
Mohammad Mahfuzur Rahman Chowdhury ◽  
Rifat Zaman ◽  
Md Amanur Rasul ◽  
Akm Shahadat Hossain ◽  
Shafiqul Alam Chowdhury ◽  
...  
Keyword(s):  
Renal Function ◽  
Low Dose ◽  
Ureteropelvic Junction Obstruction ◽  
Percutaneous Nephrostomy ◽  
Ureteropelvic Junction ◽  
College Hospital ◽  
Medical College ◽  
Split Renal Function

Introduction and objectives: Congenital ureteropelvic junction obstruction (UPJO) is the most common cause of hydronephrosis. Management protocols are based on the presence of symptoms and when the patient is asymptomatic the function of the affected kidney determines the line of treatment. Percutaneous nephrostomy (PCN) became a widely accepted procedure in children in the 1990s. The aim of the study was to evaluate the results of performing percutaneous nephrostomy (PCN) in all patients with UPJO and split renal function (SRF) of less than 10% in the affected kidney, because the management of such cases is still under debate. Methods:This prospective clinical trial was carried out at Dhaka Medical College Hospital from January 2014 to December 2016. Eighteen consecutive patients who underwent PCN for the treatment of unilateral UPJO were evaluated prospectively. In these children, ultrasonography was used for puncture and catheter insertion. Local anesthesia with sedation or general anesthesia was used for puncture. Pig tail catheters were employed. The PCN remained in situ for at least 4 weeks, during which patients received low-dose cephalosporin prophylaxis. Repeat renography was done after 4 weeks. When there was no significant improvement in split renal function (10% or greater) and PCN drainage (greater than 200 ml per day) then nephrectomies were performed otherwise pyeloplasties were performed. The patients were followed up after pyeloplasty with renograms at 3 months and 6 months post operatively. Results: All the patients had severe hydronephrosis during diagnosis and 14 patients with unilateral UPJO were improved after PCN drainage and underwent pyeloplasty. The rest four patients that did not show improvement in the SRF and total volume of urine output underwent nephrectomy. In the patients with unilateral UPJO who improved after PCN drainage, the SRF was increased to 26.4% ±8.6% (mean± SD) after four weeks and pyeloplasty was performed. At three and six months follow-up, SRF value was 29.2% ±8.5% and 30.8.2% ±8.8% respectively. Conclusion: Before planning of nephrectomy in poorly functioning kidneys (SRF < 10%) due to congenital UPJO, PCN drainage should be done to asses improvement of renal function. Bangladesh Journal of Urology, Vol. 20, No. 2, July 2017 p.61-64

Differentiating Pagetoid Bowen's disease from Paget's disease on the nipple‐areola complex: Two unique, challenging cases

2021 ◽  
Author(s):  
Leire Barrutia ◽  
Gerardo Martínez‐García ◽  
Alba Santamarina‐Albertos ◽  
Esther Leticia Garabito Solovera ◽  
Víctor Volo ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Bowen’S Disease ◽  
Bowen's Disease ◽  
Nipple Areola Complex ◽  
Areola Complex

Not All Cases of Mammary Paget’s Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!

2021 ◽  
pp. 106689692110029
Author(s):  
Kerschen Anja ◽  
Dano Hélène ◽  
Van Eeckhout Pascal ◽  
Marot Liliane ◽  
Van Bockstal Mieke
Keyword(s):  
Present Report ◽  
Paget’S Disease ◽  
Growth Factor Receptor ◽  
Punch Biopsy ◽  
Paget's Disease ◽  
Cytokeratin 7 ◽  
In Situ Carcinoma ◽  
Epidermal Growth ◽  
Mammary Paget’S Disease

Mammary Paget’s disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resulted in an initial misdiagnosis and, subsequently, a delay in the patient's follow-up. Additional immunohistochemistry for GATA binding protein 3 (GATA3) and human epidermal growth factor receptor 2 (HER2), as well as a second opinion of a breast pathologist, resulted in the diagnosis of mammary Paget's disease. The aim of this article is to raise awareness among pathologists and prevent them from misdiagnosing CK7-negative Paget disease of the breast.

scholarly journals Paget’s Disease of the Breast in a Patient with Amyopathic Dermatomyositis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Sirin Yasar ◽  
Gunay Gurleyik ◽  
Yesim Sabuncuoglu ◽  
Ali Aktekin ◽  
Bulent Yasar ◽  
...  
Keyword(s):  
Rare Case ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Lymph Node Biopsy ◽  
Amyopathic Dermatomyositis ◽  
Dermatology Department ◽  
Node Biopsy ◽  
Areola Complex ◽  
Underlying Malignancy ◽  
Recurrent Malignancy

Amyopathic dermatomyositis (AD) can be a part of paraneoplastic syndrome of an underlying malignancy. Paget’s disease is a rare form of breast cancer. We present a very rare case of Paget’s disease associated with AD. Paget’s disease has been diagnosed in a patient with AD who is under surveillance of dermatology department. The patient has undergone central lumpectomy with removal of the nipple-areola complex and sentinel lymph node biopsy. Surgical margins after lumpectomy and sentinel node biopsy were negative. The whole breast irradiation was performed after surgery. The patient receives medical treatment for AD of which lesions regressed in 1 year during the follow-up period. This is a very rare case of Paget’s disease diagnosed in a patient with AD. Female patients with dermatomyositis have been absolutely recommended to undergo screening for breast and gynaecological malignancies. AD may be an early finding of primary or recurrent malignancy of the breast.

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