A Study of the in Vitro Release Profile of a New Prostaglandin E2Delivery System for Local Administration in Obstetrics

1983 ◽  
Vol 62 (s113) ◽  
pp. 59-61 ◽  
Author(s):  
A. S. Harris ◽  
P. Stenberg ◽  
U. Ulmsten
Keyword(s):  
In Vitro Release ◽  
Release Profile ◽  
Local Administration ◽  
Vitro Release

Development and In Vitro Characterization of Paclitaxel Loaded Solid Lipid Nanoparticles

2019 ◽  
Vol 9 (1) ◽  
pp. 76-85 ◽  
Author(s):  
R. Nithya ◽  
K. Siram ◽  
R. Hariprasad ◽  
H. Rahman
Keyword(s):  
Zeta Potential ◽  
Solid Lipid Nanoparticles ◽  
In Vitro Release ◽  
Lipid Nanoparticles ◽  
Release Profile ◽  
Mcf7 Cells ◽  
Solid Lipid ◽  
Cancerous Cells ◽  
Vitro Release

Background: Paclitaxel (PTX) is a potent anticancer drug which is highly effective against several cancers. Solid lipid nanoparticles (SLNs) loaded with anticancer drugs can enhance its toxicity against tumor cells at low concentrations. Objective: To develop and characterize SLNs of PTX (PSLN) to enhance its toxicity against cancerous cells. Method: The solubility of PTX was screened in various lipids. Solid lipid nanoparticles of PTX (PSLN) were developed by hot homogenization method using Cutina HR and Gelucire 44/14 as lipid carriers and Solutol HS 15 as a surfactant. PSLNs were characterized for size, morphology, zeta potential, entrapment efficiency, physical state of the drug and in vitro release profile in 7.4 pH phosphate buffer saline (PBS). The ability of PTX to enhance toxicity towards cancerous cells was tested by performing cytoxicity assay in MCF7 cell line. Results: Solubility studies of PTX in lipids indicated better solubility when Cutina HR and Gelucire 44/14 were used. PSLNs were found to possess a neutral zeta potential with a size range of 155.4 ± 10.7 nm to 641.9 ± 4.2 nm. In vitro release studies showed a sustained release profile for PSLN over a period of 48 hours. SLNs loaded with PTX were found to be more toxic in killing MCF7 cells at a lower concentration than the free PTX.

Structural comparison, physicochemical properties, and in vitro release profile of curcumin-loaded lyotropic liquid crystalline nanoparticle: Influence of hydrotrope as interface stabilizers

2020 ◽  
Vol 306 ◽  
pp. 112861 ◽  
Author(s):  
Juliana Ferreira de Souza ◽  
Katiusca da Silva Pontes ◽  
Thais Francine Ribeiro Alves ◽  
Cecilia Torqueti de Barros ◽  
Venancio Alves Amaral ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Liquid Crystalline ◽  
In Vitro Release ◽  
Release Profile ◽  
Structural Comparison ◽  
Vitro Release

Caffeic Acid in Dermatological Formulations: In Vitro Release Profile and Skin Absorption

2017 ◽  
Vol 20 (8) ◽  
Author(s):  
Caroline M. Spagnol ◽  
Leonardo D. Di Filippo ◽  
Vera L.B. Isaac ◽  
Marcos A. Correa ◽  
Herida R.N. Salgado
Keyword(s):  
Caffeic Acid ◽  
In Vitro Release ◽  
Release Profile ◽  
Skin Absorption ◽  
Vitro Release

Studies with Emulsion Containing trans-resveratrol: in vitro Release Profile and ex vivo Human Skin Permeation

2015 ◽  
Vol 12 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Priscila de Almeida ◽  
Michele Alves ◽  
Hudson Polonini ◽  
Stephane Calixto ◽  
Tiago Braga Gomes ◽  
...  
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Skin Permeation ◽  
In Vitro Release ◽  
Release Profile ◽  
Vitro Release

In vitro release profile of estradiol transdermal therapeutic systems

1990 ◽  
Vol 79 (7) ◽  
pp. 601-602 ◽  
Author(s):  
Norlin W. Tymes ◽  
Vinod P. Shah ◽  
Jerome P. Skelly
Keyword(s):  
In Vitro Release ◽  
Release Profile ◽  
Vitro Release
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