Side and Site of deep vein Thrombosis in Women using Oral Contraceptives

1985 ◽  
Vol 64 (5) ◽  
pp. 399-402 ◽  
Author(s):  
AsbjÖRn Kierkegaard
Keyword(s):  
Deep Vein Thrombosis ◽  
Oral Contraceptives ◽  
Vein Thrombosis ◽  
Deep Vein

scholarly journals Combination oral contraceptives – a practice-guided overview of everyday problems and their solutions

2020 ◽  
pp. 30-32
Author(s):  
DW Wolmarans ◽  
L Brand ◽  
SF Steyn
Keyword(s):  
Deep Vein Thrombosis ◽  
Side Effects ◽  
Adverse Effects ◽  
Oral Contraceptives ◽  
Cardiovascular Events ◽  
Treatment Withdrawal ◽  
Vein Thrombosis ◽  
Withdrawal Of Therapy ◽  
Deep Vein ◽  
Everyday Problems

Combination oral contraceptives (COCs) are some of the most commonly prescribed drugs for women between the ages of 15–451 and while they are accepted to be safe and highly effective, their use is often associated with a number of minor sideeffects. Considering the limited nature of this review, a detailed overview of the complete clinical profile of COCs falls beyond the current scope. Rather, we will focus on the most frequently reported side-effects of COCs that do not necessitate treatment withdrawal. Adverse effects that require immediate withdrawal of therapy are usually related to deep vein thrombosis (DVT) and other cardiovascular events, malignancies or hepatic pathology2 and would require a more in-depth review.

Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen

The Lancet ◽  
1995 ◽  
Vol 346 (8990) ◽  
pp. 1593-1596 ◽  
Author(s):  
K.W.M. Bloemenkamp ◽  
F.M. Helmerhorst ◽  
F.R. Rosendaal ◽  
J.P. Vandenbroucke ◽  
H.R. Büller
Keyword(s):  
Deep Vein Thrombosis ◽  
Oral Contraceptives ◽  
Factor V Leiden ◽  
Factor V ◽  
Third Generation ◽  
Factor V Leiden Mutation ◽  
Vein Thrombosis ◽  
Deep Vein

Obesity: risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive use

2003 ◽  
Vol 89 (03) ◽  
pp. 493-498 ◽  
Author(s):  
Morteza Abdollahi ◽  
Mary Cushman ◽  
Frits Rosendaal
Keyword(s):  
Deep Vein Thrombosis ◽  
Oral Contraceptive ◽  
Oral Contraceptives ◽  
Case Control Study ◽  
Age Groups ◽  
Case Control ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Control Study ◽  
Age And Sex

SummaryDeep vein thrombosis (DVT) is a common disease with an annual incidence of about 1 in 1000. Many risk factors have already been studied, both genetic and acquired. It is unclear whether obesity affects thrombotic risk in unselected patients. Obesity is common, with a prevalence of 20-25% and may therefore have a considerable impact on the overall incidence of thrombosis. We evaluated the risk of thrombosis due to overweight and obesity using data from a large population based case-control study.Four hundred and fifty-four consecutive patients with a first episode of objectively diagnosed thrombosis from three Anticoagulation Clinics in the Netherlands were enrolled in a case-control study. Controls were matched on age and sex to patients and were introduced by the patients. All patients completed a standard questionnaire and interview, with weight and height measured under standard conditions. The associations of obesity with clotting factor levels were studied to investigate possible mechanisms.Obesity (BMI ≥30 kg/m2) increased the risk of thrombosis twofold (CI95: 1.5 to 3.4), adjusted for age and sex. Obese individuals had higher levels of factor VIII and factor IX, but not of fibrinogen. The effect on risk of obesity was not changed after adjustment for coagulation factors levels (fibrinogen, F VIII, F IX, D-dimer). The relative risk estimates were similar in different age groups and in both sexes, indicating a larger absolute effect in older age groups. Evaluation of the combined effect of obesity and oral contraceptive pills among women aged 15-45 revealed that oral contraceptives further increased the effect of obesity on the risk of thrombosis, leading to 10-fold increased risk amongst women with a BMI greater than 25 kg/m2 who used oral contraceptives.Obesity is a risk factor for deep vein thrombosis. Among women with a BMI greater than 25 kg/m2 the synergistic effect with oral contraceptives should be considered when prescribing these.

Isolated Iliac Vein Thrombosis During Oral Contraceptive Therapy in Three "Normal" Women

1997 ◽  
Vol 3 (4) ◽  
pp. 284-287 ◽  
Author(s):  
Antonio Girolami ◽  
Paolo Prandoni ◽  
Alessandra Zanardi ◽  
Bruno Girolami ◽  
Ezio Zanon
Keyword(s):  
Deep Vein Thrombosis ◽  
Oral Contraceptive ◽  
Clinical Evaluation ◽  
Oral Contraceptives ◽  
Iliac Vein ◽  
Vein Thrombosis ◽  
Contraceptive Therapy ◽  
Iliac Vein Thrombosis ◽  
Deep Vein ◽  
Oral Contraceptive Therapy

Isolated iliac vein thrombosis appears to be a rare clinical entity. It is usually due to extrinsic compression on the iliac vein with consequent stasis. Diagnosis may be difficult since compression ultrasonography is usually negative. Only phlebography is surely diagnostic. This procedure should be carried out whenever there is a discrepancy between the clinical evaluation and a negative sonography. We report three women on oral contraceptive therapy in whom a diagnosis of isolated iliac vein thrombosis was suspected clinically and confirmed phlebographically. No other congenital or acquired potential cause of thrombosis was present in the propositae but for the oral contraceptives. Oral contraceptives had been taken for 12, 3, and 2 months respectively for three patients before thrombosis occurred. Two of the propositae were 25 years old and the third was 54. The latter patient had been given oral contraceptives to "prevent osteoporosis" after menopause. The discontinuation of the pill together with usual heparin and coumarin therapy were effective in every instance. A specific pathogenic role of the oral contraceptives may be surmised. In fact, no isolated iliac vein thrombosis was found in a control group of 20 women of fertile age we showed to have idiopathic deep vein thrombosis of the legs. This article emphasizes once again the importance of a careful clinical evaluation in the suspicion of deep vein thrombosis. Key Words: Oral contraceptive therapy-Deep vein thrombosis-Iliac vein thrombosis.

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