Bone Resorption in Chronic Otitis Media the Role of Mast Cells

1985 ◽  
Vol 100 (1-2) ◽  
pp. 72-80 ◽  
Author(s):  
Gilead Berger ◽  
Michael Hawke ◽  
J. Kenneth Ekem
2012 ◽  
Vol 126 (8) ◽  
pp. 775-779
Author(s):  
A O Calli ◽  
A Sari ◽  
F Cakalagaoglu ◽  
A A Altinboga ◽  
C Calli ◽  
...  

AbstractBackground:The pathogenesis of cholesteatoma remains unclear, despite several theories. Alterations in the density of mast cells positive for cluster of differentiation 117 protein (also known as CD117) can be critical to cholesteatoma formation, due to the effect on keratinocyte growth factor production. This study aimed to investigate the potential role of these mast cells in cholesteatoma pathogenesis.Methods:The number and density of mast cells positive for cluster of differentiation 117 protein were immunohistochemically analysed in 52 patients: 22 with chronic otitis media alone (group one), 25 with chronic otitis media with cholesteatoma (group two) and five controls.Results:The number of these mast cells was much higher in group two (in cholesteatoma matrix tissue) than in group one (in chronic otitis media granulation tissue) or the controls (in normal post-auricular skin). The density of these mast cells was significantly greater in group two than in group one or the controls (p < 0.05). The number and density of these mast cells was much greater in group one than in controls (p < 0.01).Conclusion:Mast cells positive for cluster of differentiation 117 protein could play a role in cholesteatoma formation. Further investigation of the role of these mast cells in cholesteatoma may suggest new ways of addressing this disorder, and may enable the development of targeted treatments.


ORL ◽  
2002 ◽  
Vol 64 (2) ◽  
pp. 95-107 ◽  
Author(s):  
Jae Y. Jung ◽  
Richard A. Chole

1981 ◽  
Vol 6 (3) ◽  
pp. 179-186 ◽  
Author(s):  
J. THOMSEN ◽  
P. BRETLAU ◽  
M. BALSLEV JØRGENSEN

Author(s):  
P J Clamp ◽  
K De-Loyde ◽  
A R Maw ◽  
S Gregory ◽  
J Golding ◽  
...  

Abstract Objective This study aimed to analyse social, health and environmental factors associated with the development of chronic otitis media by age nine. Method This was a prospective, longitudinal, birth cohort study of 6560 children, reviewed at age nine. Chronic otitis media defined as previous surgical history or video-otoscopic changes of tympanic membrane retraction, perforation or cholesteatoma. Non-affected children were used as the control group. Results Univariate analysis demonstrated an association between chronic otitis media and otorrhoea, snoring, grommet insertion, adenoidectomy, tonsillectomy, hearing loss, abnormal tympanograms and preterm birth. Multivariate analysis suggests many of these factors may be interrelated. Conclusion The association between chronic otitis media and otorrhoea, abnormal tympanograms and grommets supports the role of the Eustachian tube and otitis media (with effusion or acute) in the pathogenesis of chronic otitis media. The role of snoring, adenoidectomy and tonsillectomy is unclear. Associations suggested by previous studies (sex, socioeconomic group, parental smoking, maternal education, childcare, crowding and siblings) were not found to be significant predictors in this analysis.


1983 ◽  
Vol 8 (1) ◽  
pp. 47-51 ◽  
Author(s):  
G. G. BROWNING ◽  
G. PICOZZI ◽  
G. SWEENEY ◽  
I. T. CALDER

2007 ◽  
Vol &NA; ◽  
pp. S77
Author(s):  
Mehdi Bakhshaee ◽  
Mohsen Rajati ◽  
Mohammad Feraydouni ◽  
Ehsan Khadivi

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