Is severe dysplasia the same lesion as carcinoma in situ? 10-Year follow-up of laryngeal precancerous lesions

2012 ◽  
Vol 132 (3) ◽  
pp. 325-328 ◽  
Author(s):  
Hong Kai Zhang ◽  
Hong Gang Liu
Keyword(s):  
Carcinoma In Situ ◽  
Precancerous Lesions ◽  
Severe Dysplasia

Laryngeal Dysplasia: Epidemiology and Treatment Outcome

1995 ◽  
Vol 104 (8) ◽  
pp. 596-602 ◽  
Author(s):  
Keith E. Blackwell ◽  
Thomas C. Calcaterra ◽  
Yao-Shi Fu
Keyword(s):  
Treatment Group ◽  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
Endoscopic Therapy ◽  
Partial Laryngectomy ◽  
Severe Dysplasia ◽  
Long Term Follow Up

A retrospective analysis was undertaken of 65 patients with long-term follow-up for laryngeal squamous dysplasia. Based on the degree of dysplasia demonstrated on initial biopsy, 0 of 6 patients showing hyperkeratosis without dysplasia, 3 of 26 patients (12%) showing mild dysplasia, 5 of 15 patients (33%) showing moderate dysplasia, 4 of 9 patients (44%) showing severe dysplasia, and 1 of 9 patients (11%) showing carcinoma in situ eventually progressed to invasive carcinoma. An analysis was made of the impact of various treatment modalities in 33 patients demonstrating moderate dysplasia, severe dysplasia, or carcinoma in situ. Invasive carcinoma developed in 10 of 21 patients (48%) treated endoscopically and 0 of 12 patients treated by more aggressive therapy, including external beam radiotherapy, partial laryngectomy, or total laryngectomy. Of the patients in the endoscopic therapy group who developed invasive carcinoma, all were salvaged successfully. The overall rate of laryngeal preservation was 15 of 21 patients (71%) in the endoscopic treatment group and 11 of 12 patients (92%) in the aggressive treatment group. This difference is not statistically significant. We conclude that there is a moderately high rate of progression to invasive carcinoma in patients undergoing repeated endoscopic therapy for intraepithelial neoplasms of the larynx. However, with close, long-term follow-up, patients undergoing endoscopic therapy have an overall outcome similar to that in patients treated with partial laryngectomy or radiotherapy prior to developing invasive disease.

Estimation of The Transitional Probability Among Esophageal Cancer and Its Precancerous Lesions

2020 ◽  
Author(s):  
Yong YU ◽  
Yue XIE ◽  
Xue YANG ◽  
Jing-Xuan WANG ◽  
Zhi-Yu CHEN ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Carcinoma In Situ ◽  
Markov Models ◽  
Transition Probabilities ◽  
Precancerous Lesions ◽  
Health State ◽  
Severe Dysplasia ◽  
Mild Dysplasia ◽  
Pathological Stages

Abstract Background: To estimate the transition probabilities of esophageal cancer (EC) and its precancerous lesions during the process of canceration by Markov model, which could provide important information for EC screening with regard to choosing reasonable screening and follow-up intervals.Methods: The transition probabilities among pathological stages were estimated by establishing Markov models for the natural history of EC and repeatedly adjusting and calibrating Markov models through comparing the modeled incidence and distributions of pathological stages (alone or combined) with observed data in real world condition. Results: In one year, the probabilities were 0.024, 0.05, 0.12 for people from health state progressing to mild dysplasia (mD), mild dysplasia (mD) to moderate dysplasia (MD), and moderate dysplasia (MD) to severe dysplasia/carcinoma in situ (SD/CIS), respectively. The age-specific transition probabilities were 0.08~0.18 for severe dysplasia/carcinoma in situ (SD/CIS) progressing to intramucosal carcinoma(IC), 0.4~0.87 for intramucosal carcinoma (IC) to submucosal carcinoma (T1N0M0) (SC), and 0.2~0.85 for submucosal carcinoma (T1N0M0) (SC) to invasive carcinoma (INC). The progression probabilities increased with age and the severity of the disease. Based on the estimated transition probabilities, we predicted the incidence of EC and distributions of its pathological stages. Comparisons between modeled results with observed data confirmed the validation of our transition probabilities.Conclusion: The estimating transition probabilities of EC and its precancerous lesions were reliable and could be used to address questions such as the optimal screening frequency, screening intervals, and health economic evaluation of screening strategies.

scholarly journals Long-Term Follow-Up of Severe Dysplasia and Carcinoma In Situ of the Bronchus

2009 ◽  
Vol 4 (9) ◽  
pp. 1187-1188 ◽  
Author(s):  
Mathieu Salaün ◽  
Suzanna Bota ◽  
Luc Thiberville
Keyword(s):  
Carcinoma In Situ ◽  
Severe Dysplasia ◽  
Long Term Follow Up

Breast-Conserving Treatment With or Without Radiotherapy in Ductal Carcinoma-In-Situ: Ten-Year Results of European Organisation for Research and Treatment of Cancer Randomized Phase III Trial 10853—A Study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group

2006 ◽  
Vol 24 (21) ◽  
pp. 3381-3387 ◽  
Author(s):  
Nina Bijker ◽  
Philip Meijnen ◽  
Johannes L. Peterse ◽  
Jan Bogaerts ◽  
Irène Van Hoorebeeck ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Phase Iii ◽  
Breast Conserving Treatment ◽  
European Organisation ◽  
Radiotherapy Group ◽  
Long Term Follow Up

Purpose The European Organisation for Research and Treatment of Cancer conducted a randomized trial investigating the role of radiotherapy (RT) after local excision (LE) of ductal carcinoma-in-situ (DCIS) of the breast. We analyzed the efficacy of RT with 10 years follow-up on both the overall risk of local recurrence (LR) and related to clinical, histologic, and treatment factors. Patients and Methods After complete LE, women with DCIS were randomly assigned to no further treatment or RT (50 Gy). One thousand ten women with mostly (71%) mammographically detected DCIS were included. The median follow-up was 10.5 years. Results The 10-year LR-free rate was 74% in the group treated with LE alone compared with 85% in the women treated by LE plus RT (log-rank P < .0001; hazard ratio [HR] = 0.53). The risk of DCIS and invasive LR was reduced by 48% (P = .0011) and 42% (P = .0065) respectively. Both groups had similar low risks of metastases and death. At multivariate analysis, factors significantly associated with an increased LR risk were young age (≤ 40 years; HR = 1.89), symptomatic detection (HR = 1.55), intermediately or poorly differentiated DCIS (as opposed to well-differentiated DCIS; HR = 1.85 and HR = 1.61 respectively), cribriform or solid growth pattern (as opposed to clinging/micropapillary subtypes; HR = 2.39 and HR = 2.25 respectively), doubtful margins (HR = 1.84), and treatment by LE alone (HR = 1.82). The effect of RT was homogeneous across all assessed risk factors. Conclusion With long-term follow-up, RT after LE for DCIS continued to reduce the risk of LR, with a 47% reduction at 10 years. All patient subgroups benefited from RT.

Lobular carcinoma in situ of the breast Detailed analysis of 99 patients with average follow-up of 24 years

1978 ◽  
Vol 2 (3) ◽  
pp. 225-252 ◽  
Author(s):  
Paul Peter Rosen ◽  
Philip H. Lieberman ◽  
David W. Braun ◽  
Cynthia Kosloff ◽  
Frank Adair
Keyword(s):  
Detailed Analysis ◽  
Carcinoma In Situ ◽  
Lobular Carcinoma ◽  
Lobular Carcinoma In Situ

scholarly journals Ductal carcinoma in situ presenting as a cystic retroareolar lesion in an African American man

2021 ◽  
Author(s):  
Amara Ndumele ◽  
Amy Kerger ◽  
Gary Tozbikian ◽  
Samilia Obeng-Gyasi ◽  
Bridget Oppong
Keyword(s):  
African American ◽  
Health Outcomes ◽  
Chest Wall ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Cystic Lesion ◽  
Ductal Carcinoma ◽  
Unusual Finding

We report an unusual finding of DCIS within a cystic lesion in a black man highlighting the need for adequate workup, and timely follow-up for men with breast/chest wall masses given the lack of screening in this population. Furthermore, we will explore how race contributes to prognosis and health outcomes.

HPV DNA patterns and disease implications in the follow-up of patients treated for HPV16 high-grade carcinoma in situ

2006 ◽  
Vol 78 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Monica Cricca ◽  
Simona Venturoli ◽  
Antonio Maria Morselli-Labate ◽  
Silvano Costa ◽  
Donatella Santini ◽  
...  
Keyword(s):  
Carcinoma In Situ ◽  
High Grade ◽  
Hpv Dna ◽  
High Grade Carcinoma
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