Small intestinal malabsorption of vitamin B12 in iron-deficient rats

Pathology ◽  
1975 ◽  
Vol 7 (1) ◽  
pp. 35-44 ◽  
Author(s):  
N.D. Yeomans ◽  
D.J.B. St John
Keyword(s):  
Vitamin B12 ◽  
Intestinal Malabsorption ◽  
Iron Deficient ◽  
Small Intestinal

scholarly journals Reticulocyte size in nutritional anemias

Blood ◽  
1976 ◽  
Vol 48 (5) ◽  
pp. 669-677 ◽  
Author(s):  
DR Clarkson ◽  
EM Moore
Keyword(s):  
Iron Deficiency ◽  
Vitamin B12 ◽  
Mean Corpuscular Volume ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Initial Development ◽  
Abrupt Decrease ◽  
Iron Saturation ◽  
Iron Deficient ◽  
B12 Deficiency

Abstract Alterations in reticulocyte size occur 2–3 days after the onset of iron deficient or megaloblastic erythropoiesis and precede, by several weeks, changes in mean corpuscular volume (MCV). Iron-deficiency anemia induced in a normal subject by repeated phlebotomies was characterized by the initial development of larger than normal reticulocytes followed by an abrupt decrease in reticulocyte size. Microreticulocytes appeared 3 days after the fall in per cent iron saturation and antedated the decrease in MCV to below normal by 6 wk. Mean reticulocyte size was disproportionately smaller than normal in patients presenting with iron deficiency. In contrast, reticulocyte size increased abruptly in a patient (and rats) 2–3 days after administration of methotrexate. Mean reticulocyte size was disproportionately larger than normal in patients presenting with folate or vitamin B12 deficiency. Specific replacement therapy with iron, folate, or vitamin B12 was quickly followed by normalization of reticulocyte size.

The Absorption of α-Tocopherol in Control Subjects and in Patients with Intestinal Malabsorption

1970 ◽  
Vol 38 (2) ◽  
pp. 197-210 ◽  
Author(s):  
M. T. MacMahon ◽  
G. Neale
Keyword(s):  
Biliary Obstruction ◽  
Pancreatic Insufficiency ◽  
Partial Gastrectomy ◽  
Exocrine Pancreatic Insufficiency ◽  
Small Intestinal Mucosa ◽  
Intestinal Lymphangiectasia ◽  
Intestinal Malabsorption ◽  
Control Subjects ◽  
Small Intestinal ◽  
Almost All

1. The absorption of physiological doses of tritiated α-tocopherol has been studied in seven control subjects and in twenty-three patients with malabsorption due to various causes. 2. Control subjects absorbed between 55·0 and 78·6% of an oral dose. Radioactivity appeared in the plasma between 1 and 3 hr, reached a peak between 5 and 9 hr, and subsequently fell exponentially with a mean half-life of 53 hr. Radioactivity in plasma was almost all associated with free α-tocopherol. 3. Absorption of α-tocopherol was most severely impaired in patients with biliary obstruction, and somewhat less severely impaired in patients with exocrine pancreatic insufficiency. Malabsorption in patients with an abnormal small intestinal mucosa varied with the severity of the condition, and could be correlated with the degree of steatorrhoea. 4. In two patients with intestinal lymphangiectasia, malabsorption of the vitamin was relatively more severe than that of fat. Mild malabsorption was found in five of the six patients who had had a partial gastrectomy. 5. The amount of radioactivity recovered from the urine in 3 days ranged from 0·0 to 21·4% of the dose given and could be correlated with the degree of absorption.

scholarly journals Prevalence of Iron, Vitamin B12 deficiency and inflammatory anaemia in treatment naive individual consecutive cancer patients: A cross sectional study.

2020 ◽  
Author(s):  
Avinash Pandey ◽  
Shivkant Singh ◽  
Raj Aryan ◽  
Krishna Murari
Keyword(s):  
Iron Deficiency ◽  
Vitamin B12 ◽  
Cancer Patients ◽  
Serum Ferritin ◽  
Transferrin Saturation ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional ◽  
Iron Deficient ◽  
Treatment Naïve ◽  
B12 Deficiency

Background: In treatment naive Indian cancer patients, prevalence of iron, B12 deficiency and inflammatory anaemia in poorly known. Aims and Objectives : To evaluate prevalence of anaemia and iron, B12 deficiency along with inflammation in treatment naive individual consecutive cancer patients. Material and Methods: All patients registered from 1st July 2019 till 31st December 2019 in Medical Oncology Outpatient Department were offered to undergo Iron profile, Serum B12 levels and Serum ferritin along with routine haematological investigations. Anaemia was defined as Haemoglobin < 11gm/dL. Transferrin saturation <20%, Serum Ferritin >300 microgram/litre and Vitamin B12 level <200 picogram/millilitre were 'cut-offs' used to define iron deficiency, inflammation and Vitamin B12 deficiency respectively. Data was analysed using descriptive statistics, frequency distribution, crosstabs and Bar Diagram in SPSS version 17.0. Pearsons Chi square test and Odds ratio was used to measure the strength of association with variables. Results: 311/441 (70.5%) were found eligible. Median age was 52 + 15.9 (Range 18-84 ) years with 144/331(46%) females. The prevalence of anaemia was 61% + 2.7 (95% CI 55-66%). Mean Haemoglobin was 9.86 + 2.08 (range 3-16) gram/decilitre. 21/311(7%) had severe anaemia (Haemoglobin < 6.9 gm/dl). 135/311 (71%), 61/189 (32%) and 89/189 (47%) anaemic patients had iron deficiency, inflammation and B12 deficiency respectively. More than 70% of Gastrointestinal (50/69), Gynaecological(17/24) and Lung Cancer(18/22) patients had underling Iron deficiency. Conclusion: Two-third of cancer patients are iron deficient. B12 deficiency and inflammation are present in half and one-third patients respectively.

Pathophysiology of small intestinal malabsorption in gerbils infected with Giardia lamblia

1992 ◽  
Vol 103 (2) ◽  
pp. 506-513 ◽  
Author(s):  
Andre Buret ◽  
James A. Hardin ◽  
Merle E. Olson ◽  
D.Grant Gall
Keyword(s):  
Giardia Lamblia ◽  
Intestinal Malabsorption ◽  
Small Intestinal
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