Plasma Free Fatty Acids in Mental Patients before and after Intravenous Administration of Insulin

1967 ◽  
Vol 19 (2) ◽  
pp. 101-105 ◽  
Author(s):  
M. Farstad
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Intravenous Administration ◽  
Mental Patients ◽  
Plasma Free Fatty Acids ◽  
Before And After

Plasma Free Fatty Acids Before and After an Intravenous Insulin Injection in Acute Schizophrenic Men

1970 ◽  
Vol 116 (531) ◽  
pp. 173-177 ◽  
Author(s):  
G. Franzén
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Sympathetic Activity ◽  
Close Relation ◽  
Insulin Injection ◽  
Healthy Controls ◽  
Plasma Free Fatty Acids ◽  
Intravenous Insulin ◽  
Before And After ◽  
Schizophrenic Patients

The possibility of abnormalities in carbohydrate metabolism in schizophrenia has been stressed by many authors (Mann 1925, Freeman et al., 1943, Braceland et al., 1945, Morgan and Pilgrim 1952, Henneman et al., 1954, Moya et al., 1958, Lingjaerde and Skaug 1959). As there is a close relation between lipid metabolism (in terms of plasma free fatty acids, FFA) and glucose metabolism Mueller (1961, 1962) tested the FFA-response to insulin-induced hypoglycaemia in chronic schizophrenic patients. He found that schizophrenics showed less reduction in FFA-values than healthy controls, in some cases even an increase. Results were later presented which tend to confirm Mueller's data (van Sickle et al., 1966). Interest was focused on increased sympathetic activity in the patients, and infusion experiments with epinephrine (van Sickle et al., 1966) and norepinephrine (Cardon and Mueller 1964) were performed without producing conclusive results.

Source of plasma free fatty acids in dogs receiving fat emulsion and heparin

1963 ◽  
Vol 204 (4) ◽  
pp. 691-695 ◽  
Author(s):  
H. C. Meng ◽  
B. Edgren
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Lipolytic Activity ◽  
Blocking Agent ◽  
Fat Emulsion ◽  
Similar Reduction ◽  
Plasma Free Fatty Acids ◽  
Fat Infusion ◽  
Plasma Ffa ◽  
Slight Rise

Unanesthetized dogs were given either 3.0 g fat/kg as a 20% fat emulsion or heparin (2 mg/kg) intravenously or both. Plasma free fatty acids (FFA) and lipolytic activity were determined at intervals. In some experiments hexamethonium (5 mg/kg), a sympathetic ganglionic blocking agent, was administered intravenously either before or after fat or heparin. In fasting dogs fat infusion produced a moderate and heparin caused a slight rise in plasma FFA. Heparin given during lipemia produced a marked elevation of plasma FFA. The plasma lipolytic activity was increased after fat emulsion or heparin. Hexamethonium reduced the fasting plasma FFA about 70% or 0.40–0.6 mEq/liter. A similar reduction of plasma FFA also was observed when hexamethonium was administered during fat infusion or after heparin. Hexamethonium did not affect the increase in plasma lipolytic activity following the administration of fat emulsion or heparin. It seems probable that the increase in plasma FFA observed after intravenous infusion of fat emulsion or heparin is mainly due to the result of intravascular lipolysis.

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