Delay in the Absolute Latency of Auditory Brainstem Response (ABR) Component P1in Acute Inflammatory Demyelinating Disease

Introduction: An ischemic stroke is a clinical condition that affects thousands of people worldwide. As a result of this injury, neuronal death can be observed, and in the natural course of recovery, the individual may develop sepsis. Sepsis is a systemic inflammatory response that can lead the patient to death. To assess the clinical condition of a patient with this condition, the Auditory Brainstem Response (ABR) can be useful, since it is not an invasive procedure, it is a fast technique and it can be done at the bedside. Purpose: To assess auditory brainstem response (ABR) latency values in gerbils subjected to ischemia and sepsis. Methods: ABR values were collected from 72 adult male gerbils, which were divided into six groups: control, sepsis, ischemia, sham, ischemia with sepsis, and sham with sepsis. For the induction of sepsis, lipopolysaccharide (LPS) was applied intraperitoneally in gerbils. The animals were anesthetized with a ketamine/xylazine combination before collection; their ABR were collected before any procedure (base collection), after ischemia, and 24 hours after the application of LPS. The absolute latency of wave IV was evaluated, and the values were compared between groups. Results: There were significant differences in the groups submitted to sepsis in the latency value of wave IV in relation with the other groups. Conclusion: ABR was sensitive to sepsis with the increase in latency of wave IV during the development of the disease in the experimental model used.

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Auditory Brainstem Response: reference-values for age

CoDAS ◽

10.1590/2317-1782/2014469in ◽

2014 ◽

Vol 26 (2) ◽

pp. 117-121 ◽

Cited By ~ 3

Author(s):

Luana Araujo Cruz Rosa ◽

Marcia Rumi Suzuki ◽

Rosanna Giaffredo Angrisani ◽

Marisa Frassom Azevedo

Keyword(s):

Reference Values ◽

Auditory Brainstem Response ◽

Auditory Brainstem ◽

Auditory Brainstem Responses ◽

Age Group ◽

Group Methods ◽

Brainstem Response ◽

Term Newborns ◽

Absolute Latency ◽

Preterm Newborns

PURPOSE: To study the absolute latencies of waves I , III and V and interpeak I-III , III-V and I-V of Auditory brainstem responses obtained in preterm newborns in relation to post-conceptual age, term newborns and six months of age infants, establishing reference values for each age group. METHODS: Retrospective study realized through the analysis of tests performed on 80 infants divided into four groups, being the group one composed per newborns assessed between 35 and 36 weeks post-conceptual age; group two by newborns assessed between 37 and 38 weeks; group three with newborns reviewed between 39 to 40 weeks; and group four with infants evaluated with six months. RESULTS: The wave I absolute latency in the group one was 1.81 ms, decreasing to 1.79 ms in groups two and three, and to 1.70 ms in group four. The wave III latency in group one was 4.74 ms, decreasing to 4.62 ms in group two, to 4.56 ms in the group three and to 4.37 ms in the group four. The wave V latency in group one was 7.14 ms, in the group two it was 7.05 ms, in the group three 6.90 ms; and in the group four it was 6.50 ms. Interpeak latencies were also decreased in all groups. CONCLUSION: The latencies studied decreased with the increasing age and were similar values with the international literature.

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Effect of Stimulus Rates in Chirp and Click Evoked Auditory Brainstem Response in Adults with Normal Hearing Sensitivity

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2020.v28i3.287 ◽

2021 ◽

Vol 28 (3) ◽

pp. 248-254

Author(s):

Susmi Pani ◽

Archita Sahoo ◽

Indranil Chatterjee ◽

Palash Dutta

Keyword(s):

Repetition Rate ◽

Auditory Brainstem ◽

Normal Hearing ◽

Auditory Brainstem Responses ◽

Stimulus Repetition ◽

Hearing Sensitivity ◽

Brainstem Response ◽

Absolute Latency ◽

The Absolute ◽

Stimulus Repetition Rate

Introduction The effects of increasing stimulus repetition rate on the ABR using click stimuli have been investigated in normal and hearing impaired subjects with neurologic abnormality but there is limited study on the effect of stimulus repetition rate on ABR using chirp stimuli. The present study aims to compare the chirp evoked auditory brainstem responses with reference to changes in latency of peaks, interaural latency differences and interwave latency intervals as a function of rate and compare those responses with the click evoked auditory brainstem responses, in normal hearing subjects. Materials and Methods Total 30 normally hearing adults were considered for this study. All participants were screened for normal hearing sensitivity upto 8 kHz in pure tone audiometry for middle ear pathology and central auditory processing disorder. Four parameters of ABR were considered to assess in this study including absolute latency, interwave latency intervals, latency-rate function and interaural latency. ABR was done based on the protocol of this study. Results Results revealed that there was a significant difference in the absolute latency and interwave intervals when the stimulus repetition rate was increased. Conclusion The latencies of wave III and V increases and waveform morphology changed as the stimulus repetition rate increased above 20/sec. The absolute latency of wave III and V was found to be shorter than clicks and can be used especially in newborn hearing evaluation assuming in shorter time window.

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Hit and False-Alarm Rates of Selected ABR Indices in Differentiating Cochlear Disorders From Acoustic Tumors

American Journal of Audiology ◽

10.1044/1059-0889.0501.90 ◽

1996 ◽

Vol 5 (1) ◽

pp. 90-96 ◽

Cited By ~ 4

Author(s):

Frank E. Musiek ◽

Cynthia A. McCormick ◽

Raymond M. Hurley

Keyword(s):

False Alarm ◽

Amplitude Ratio ◽

High Specificity ◽

Auditory Brainstem ◽

Latency Difference ◽

Cochlear Pathology ◽

Brainstem Response ◽

Absolute Latency ◽

Two Indices ◽

Low Sensitivity

We performed a retrospective study of 26 patients with acoustic tumors and 26 patients with otologically diagnosed cochlear pathology to determine the sensitivity (hit rate), specificity (false-alarm rate), and efficiency of six auditory brainstem response indices. In addition, a utility value was determined for each of these six indices. The I–V interwave interval, the interaural latency difference, and the absolute latency of wave V provided the highest hit rates, the best A’ values and good utility. The V/I amplitude ratio index provided high specificity but low sensitivity scores. In regard to sensitivity and specificity, using the combination of two indices provided little overall improvement over the best one-index measures.

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