Hit and False-Alarm Rates of Selected ABR Indices in Differentiating Cochlear Disorders From Acoustic Tumors

1996 ◽  
Vol 5 (1) ◽  
pp. 90-96 ◽  
Author(s):  
Frank E. Musiek ◽  
Cynthia A. McCormick ◽  
Raymond M. Hurley
Keyword(s):  
False Alarm ◽  
Amplitude Ratio ◽  
High Specificity ◽  
Auditory Brainstem ◽  
Latency Difference ◽  
Cochlear Pathology ◽  
Brainstem Response ◽  
Absolute Latency ◽  
Two Indices ◽  
Low Sensitivity

We performed a retrospective study of 26 patients with acoustic tumors and 26 patients with otologically diagnosed cochlear pathology to determine the sensitivity (hit rate), specificity (false-alarm rate), and efficiency of six auditory brainstem response indices. In addition, a utility value was determined for each of these six indices. The I–V interwave interval, the interaural latency difference, and the absolute latency of wave V provided the highest hit rates, the best A’ values and good utility. The V/I amplitude ratio index provided high specificity but low sensitivity scores. In regard to sensitivity and specificity, using the combination of two indices provided little overall improvement over the best one-index measures.

scholarly journals Auditory brainstem response in gerbils submitted to ischemia and sepsis

CoDAS ◽  
2015 ◽  
Vol 27 (2) ◽  
pp. 155-159
Author(s):  
Janaina Patricio de Lima ◽  
Irineu Tadeu Velasco ◽  
Denise Frediane Barbeiro ◽  
Eliane Schochat
Keyword(s):  
Ischemic Stroke ◽  
Auditory Brainstem Response ◽  
Neuronal Death ◽  
Clinical Condition ◽  
Invasive Procedure ◽  
Auditory Brainstem ◽  
The Other ◽  
Brainstem Response ◽  
Absolute Latency ◽  
The Individual

Introduction: An ischemic stroke is a clinical condition that affects thousands of people worldwide. As a result of this injury, neuronal death can be observed, and in the natural course of recovery, the individual may develop sepsis. Sepsis is a systemic inflammatory response that can lead the patient to death. To assess the clinical condition of a patient with this condition, the Auditory Brainstem Response (ABR) can be useful, since it is not an invasive procedure, it is a fast technique and it can be done at the bedside. Purpose: To assess auditory brainstem response (ABR) latency values in gerbils subjected to ischemia and sepsis. Methods: ABR values were collected from 72 adult male gerbils, which were divided into six groups: control, sepsis, ischemia, sham, ischemia with sepsis, and sham with sepsis. For the induction of sepsis, lipopolysaccharide (LPS) was applied intraperitoneally in gerbils. The animals were anesthetized with a ketamine/xylazine combination before collection; their ABR were collected before any procedure (base collection), after ischemia, and 24 hours after the application of LPS. The absolute latency of wave IV was evaluated, and the values were compared between groups. Results: There were significant differences in the groups submitted to sepsis in the latency value of wave IV in relation with the other groups. Conclusion: ABR was sensitive to sepsis with the increase in latency of wave IV during the development of the disease in the experimental model used.

scholarly journals Auditory Brainstem Response: reference-values for age

CoDAS ◽  
2014 ◽  
Vol 26 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Luana Araujo Cruz Rosa ◽  
Marcia Rumi Suzuki ◽  
Rosanna Giaffredo Angrisani ◽  
Marisa Frassom Azevedo
Keyword(s):  
Reference Values ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Age Group ◽  
Group Methods ◽  
Brainstem Response ◽  
Term Newborns ◽  
Absolute Latency ◽  
Preterm Newborns

PURPOSE: To study the absolute latencies of waves I , III and V and interpeak I-III , III-V and I-V of Auditory brainstem responses obtained in preterm newborns in relation to post-conceptual age, term newborns and six months of age infants, establishing reference values for each age group. METHODS: Retrospective study realized through the analysis of tests performed on 80 infants divided into four groups, being the group one composed per newborns assessed between 35 and 36 weeks post-conceptual age; group two by newborns assessed between 37 and 38 weeks; group three with newborns reviewed between 39 to 40 weeks; and group four with infants evaluated with six months. RESULTS: The wave I absolute latency in the group one was 1.81 ms, decreasing to 1.79 ms in groups two and three, and to 1.70 ms in group four. The wave III latency in group one was 4.74 ms, decreasing to 4.62 ms in group two, to 4.56 ms in the group three and to 4.37 ms in the group four. The wave V latency in group one was 7.14 ms, in the group two it was 7.05 ms, in the group three 6.90 ms; and in the group four it was 6.50 ms. Interpeak latencies were also decreased in all groups. CONCLUSION: The latencies studied decreased with the increasing age and were similar values with the international literature.

scholarly journals Effects of Secondhand Smoke Exposure on Hearing and Auditory Evoked Potentials, ABR and AMLR in Young Adults

2018 ◽  
Vol 29 (08) ◽  
pp. 685-695
Author(s):  
Ishara Ramkissoon ◽  
Mihika Batavia
Keyword(s):  
Evoked Potentials ◽  
Amplitude Ratio ◽  
Auditory Brainstem ◽  
Auditory Function ◽  
Hearing Sensitivity ◽  
Middle Latency Response ◽  
Auditory Middle Latency Response ◽  
Brainstem Response ◽  
Shs Exposure ◽  
The Right

AbstractPopulation health is impacted by environmental secondhand smoke (SHS) exposure. Although the negative health effects of SHS exposure include respiratory problems in children (nonsmokers) as seen in cigarette smokers, other health impacts such as sensory function are not assumed to be the same for both passive nonsmokers and smokers. However, hearing loss was recently reported in adolescents and aging adults with SHS exposure, suggesting that SHS might impact auditory function similarly to cigarette smoking. Specific effects of SHS exposure on the central auditory system have not been fully described.To measure auditory function via pure-tone audiometry and evoked potentials in young nonsmoking adults aged 18–23 yr who reported exposure to environmental SHS.Participants were selected for the SHS-exposed (SHS-E) group first, followed by age and gender matched individuals for the SHS-unexposed (SHS-U) group. Self-reported nonsmoker status was confirmed by biochemical analysis of urine for cotinine level.Potential participants (N = 208) completed a questionnaire about health, smoking history, SHS exposure, and hearing ability. Individuals with any neurological conditions, alcohol/drug dependencies, excessive noise exposure, using certain medications, or current smokers were excluded. Twenty-two nonsmokers in excellent health consented to participate. Participants in the SHS-E group reported SHS exposure in home, work, or social settings for an extensive time period. Participants in the SHS-U group did not live with smokers and reported no SHS exposure, medication use, tinnitus, or any chemical exposures. Statistical analysis was conducted on data from 20 participants, 10 per group with a mean age of 20 yr.Participants underwent auditory procedures in one session in an IAC sound-treated room, including otoscopy, tympanometry, pure-tone threshold evaluation, auditory brainstem response per ear, and a three-channel auditory middle latency response in the right ear. The primary study outcomes were hearing thresholds measured (dB HL) at five frequencies, and evoked potential wave latencies (I, III, V, Na, Pa, Nb, Pb) and amplitudes (V–I, Na–Pa, Pa–Nb, Nb–Pb). It was hypothesized that SHS-exposed individuals would have poorer hearing sensitivity (threshold >25 dB HL) and abnormal central auditory function (longer latencies; smaller amplitudes) based on evoked potentials. Statistical analyses focused on identification of group differences in hearing and central auditory function.All participants had normal hearing sensitivity (thresholds ≤25 dB HL) with no significant group differences. The V/I amplitude ratio in the right ear was significantly decreased in SHS-exposed individuals (p < 0.05). Auditory brainstem response latencies were not significantly different between participant groups or ears. Wave Pb latency was significantly increased in SHS-exposed individuals (p < 0.01). Auditory middle latency response relative amplitudes were significantly different from each other at every electrode site (Cz, Fz, C4) but not between groups. Overall, the Na–Pa complex was highest in amplitude at all three electrode sites.This preliminary study indicated toxic effects of SHS exposure by evoked potentials with decreased V/I amplitude ratio and longer (delayed) Pb latency in young adults. Further studies should corroborate these findings to facilitate clinical recommendations.

Effects of Stimulus Repetition Rate and Frequency on the Auditory Brainstem Response in Normal, Cochlear-Impaired, and VIII Nerve/Brainstem-Impaired Subjects

1983 ◽  
Vol 26 (4) ◽  
pp. 560-567 ◽  
Author(s):  
Cynthia G. Fowler ◽  
Douglas Noffsinger
Keyword(s):  
Repetition Rate ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
S Waves ◽  
Rate Dependent ◽  
Cochlear Pathology ◽  
Brainstem Response ◽  
Latency Shift ◽  
Stimulus Repetition Rate ◽  
Dual Mechanism

The effects of signal repetition rate and frequency on the auditory brainstem responses of normal listeners, of persons with cochlear lesions, and of persons with VIII nerve/brainstem lesions were evaluated. The normal group exhibited more waves I and II than did the cochlear and VIII/brainstem groups. The normal and cochlear groups exhibited more waves III and V than did the VIII nerve/brainstem group. The latency of wave I was not different among groups, whereas wave V was significantly later in the VIII nerve/brainstem group than in the other groups. Waves I, III, and V were later for 50/s than for 10/s. Waves I and III displayed shorter latencies for 4000 Hz than for 2000 Hz, whereas wave V displayed similar latencies for the two stimuli. In conclusion, cochlear pathology (⩽65 dB HL) does not prolong the latencies of waves I and V. A dual mechanism is discussed to explain the rate-dependent latency shift of wave V.

Decision Analysis of Auditory Brainstem Responses and Rotational Vestibular Tests in Acoustic Tumor Diagnosis

1987 ◽  
Vol 96 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Charles A. Mangham
Keyword(s):  
Decision Analysis ◽  
High Sensitivity ◽  
High Specificity ◽  
Cost Effective ◽  
Auditory Brainstem ◽  
Tumor Diagnosis ◽  
Auditory Brainstem Responses ◽  
Test Protocol ◽  
Brainstem Response ◽  
Acoustic Tumor

This study addresses the problem of the escalation of the costs of medical care which make diagnosis of acoustic tumor expensive. Specifically, we examined the hypothesis that a test protocol of the auditory brainstem response (ABR) in parallel with sinusoidal harmonic acceleration (SHA) is more cost-effective in identification of the risk of tumor than ABR alone. The subjects were 74 patients with acoustic tumors and 78 controls. ABR and SHA data from these subjects were submitted to decision analysis. ABR was more cost-effective than the protocol of ABR in parallel with SHA. Using these data, we outlined a “decision tree” for acoustic tumor diagnosis that fit the goals of high sensitivity when earlier probability of tumor was high, and high specificity when earlier probability of tumor was low.

Comparison of 1000-Hz Toneburst and Click Stimuli in Otoneurologic ABR

1995 ◽  
Vol 4 (2) ◽  
pp. 55-60 ◽  
Author(s):  
Kathleen C. M. Campbell ◽  
Barbara A. Brady
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sensitivity And Specificity ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Clinical Interpretation ◽  
Eighth Nerve ◽  
Latency Difference ◽  
Brainstem Response ◽  
Response Testing

The present study compares the utility of click and 1000-Hz toneburst stimuli in otoneurologic auditory brainstem response testing in 45 patients with cochlear sensorineural hearing loss and in 13 patients with tumors affecting the eighth nerve. Waves I and III occurred more frequently for the click stimulus than for the 1000-Hz stimulus in ears without tumors. In ears with tumors, Waves I and III were generally absent for both stimuli. Wave V was generally present in response to both stimuli. The Wave V interaural latency difference (ILD V) was significantly different between groups for both stimuli but was not significantly different between stimuli. The sensitivity and specificity were similar for the two stimuli. In selected cases and as an adjuvant measure, the additional use of the 1000-Hz toneburst was useful. Recommendations for clinical interpretation and application are discussed.

scholarly journals Effect of Stimulus Rates in Chirp and Click Evoked Auditory Brainstem Response in Adults with Normal Hearing Sensitivity

2021 ◽  
Vol 28 (3) ◽  
pp. 248-254
Author(s):  
Susmi Pani ◽  
Archita Sahoo ◽  
Indranil Chatterjee ◽  
Palash Dutta
Keyword(s):  
Repetition Rate ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Auditory Brainstem Responses ◽  
Stimulus Repetition ◽  
Hearing Sensitivity ◽  
Brainstem Response ◽  
Absolute Latency ◽  
The Absolute ◽  
Stimulus Repetition Rate

Introduction The effects of increasing stimulus repetition rate on the ABR using click stimuli have been investigated in normal and hearing impaired subjects with neurologic abnormality but there is limited study on the effect of stimulus repetition rate on ABR using chirp stimuli. The present study aims to compare the chirp evoked auditory brainstem responses with reference to changes in latency of peaks, interaural latency differences and interwave latency intervals as a function of rate and compare those responses with the  click evoked auditory brainstem responses, in normal hearing subjects. Materials and Methods Total 30 normally hearing adults were considered for this study. All participants were screened for normal hearing sensitivity upto 8 kHz in pure tone audiometry for middle ear pathology and central auditory processing disorder. Four parameters of ABR were considered to assess in this study including absolute latency, interwave latency intervals, latency-rate function and interaural latency. ABR was done based on the protocol of this study. Results Results revealed that there was a significant difference in the absolute latency and interwave intervals when the stimulus repetition rate was increased. Conclusion The latencies of wave III and V increases and waveform morphology changed as the stimulus repetition rate increased above 20/sec. The absolute latency of wave III and V was found to be shorter than clicks and can be used especially in newborn hearing evaluation assuming in shorter time window.

scholarly journals Input and Output Compensation for the Cochlear Traveling Wave Delay in Wide-Band ABR Recordings: Implications for Small Acoustic Tumor Detection

2009 ◽  
Vol 20 (02) ◽  
pp. 099-108 ◽  
Author(s):  
Manuel Don ◽  
Claus Elberling ◽  
Erin Maloff
Keyword(s):  
Traveling Wave ◽  
Indirect Evidence ◽  
High Specificity ◽  
Wide Band ◽  
Tumor Detection ◽  
Auditory Brainstem ◽  
Neural Activation ◽  
Actual Use ◽  
Brainstem Response ◽  
Single Data

Background: The Stacked ABR (auditory brainstem response) attempts at the output of the auditory periphery to compensate for the temporal dispersion of neural activation caused by the cochlear traveling wave in response to click stimulation. Compensation can also be made at the input by using a chirp stimulus. It has been demonstrated that the Stacked ABR is sensitive to small tumors that are often missed by standard ABR latency measures. Purpose: Because a chirp stimulus requires only a single data acquisition run whereas the Stacked ABR requires six, we try to evaluate some indirect evidence justifying the use of a chirp for small tumor detection. Research Design: We compared the sensitivity and specificity of different Stacked ABRs formed by aligning the derived-band ABRs according to (1) the individual's peak latencies, (2) the group mean latencies, and (3) the modeled latencies used to develop a chirp. Results: For tumor detection with a chosen sensitivity of 95%, a relatively high specificity of 85% may be achieved with a chirp. Conclusion: It appears worthwhile to explore the actual use of a chirp because significantly shorter test and analysis times might be possible.

The Effect of Kalman-Weighted Averaging and Artifact Rejection on Residual Noise During Auditory Brainstem Response Testing

2019 ◽  
Vol 28 (1) ◽  
pp. 114-124
Author(s):  
Linda W. Norrix ◽  
Julie Thein ◽  
David Velenovsky
Keyword(s):  
Repeated Measures ◽  
Auditory Brainstem ◽  
Weighted Averaging ◽  
Auditory Brainstem Responses ◽  
Residual Noise ◽  
Electrophysiological Recordings ◽  
Artifact Rejection ◽  
Brainstem Response ◽  
Active Motor ◽  
Averaging Time

Purpose Low residual noise (RN) levels are critically important when obtaining electrophysiological recordings of threshold auditory brainstem responses. In this study, we examine the effectiveness and efficiency of Kalman-weighted averaging (KWA) implemented on the Vivosonic Integrity System and artifact rejection (AR) implemented on the Intelligent Hearing Systems SmartEP system for obtaining low RN levels. Method Sixteen adults participated. Electrophysiological measures were obtained using simultaneous recordings by the Vivosonic and Intelligent Hearing Systems for subjects in 2 relaxed conditions and 4 active motor conditions. Three averaging times were used for the relaxed states (1, 1.5, and 3 min) and for the active states (1.5, 3, and 6 min). Repeated-measures analyses of variance were used to examine RN levels as a function of noise reduction strategy (i.e., KWA, AR) and averaging time. Results Lower RN levels were obtained using KWA than AR in both the relaxed and active motor states. Thus, KWA was more effective than was AR under the conditions examined in this study. Using KWA, approximately 3 min of averaging was needed in the relaxed condition to obtain an average RN level of 0.025 μV. In contrast, in the active motor conditions, approximately 6 min of averaging was required using KWA. Mean RN levels of 0.025 μV were not attained using AR. Conclusions When patients are not physiologically quiet, low RN levels are more likely to be obtained and more efficiently obtained using KWA than AR. However, even when using KWA, in active motor states, 6 min of averaging or more may be required to obtain threshold responses. Averaging time needed and whether a low RN level can be attained will depend on the level of motor activity exhibited by the patient.

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