Chitosan microparticle preparation for controlled drug release by response surface methodology

2003 ◽  
Vol 20 (6) ◽  
pp. 791-797 ◽  
Author(s):  
J. A. Ko ◽  
H. J. Park ◽  
Y. S. Park ◽  
S. J. Hwang ◽  
J. B. Park
Keyword(s):  
Response Surface Methodology ◽  
Drug Release ◽  
Response Surface ◽  
Controlled Drug Release

From formulation of acrylamide-based hydrogels to their optimization for drug release using response surface methodology

2018 ◽  
Vol 92 ◽  
pp. 20-25 ◽  
Author(s):  
Farzaneh Sabbagh ◽  
Ida Idayu Muhamad ◽  
Zahra Nazari ◽  
Peyman Mobini ◽  
Sara Baghban Taraghdari
Keyword(s):  
Response Surface Methodology ◽  
Drug Release ◽  
Response Surface

scholarly journals Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation

2020 ◽  
Vol Volume 14 ◽  
pp. 5325-5336
Author(s):  
Afrasim Moin ◽  
Hosahalli V Gangadharappa ◽  
Mohd Adnan ◽  
Syed M Rizvi ◽  
Syed A Ashraf ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Drug Release ◽  
Response Surface ◽  
Polymer Matrices ◽  
Natural Polymer ◽  
In Vivo Evaluation

scholarly journals Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Jadupati Malakar ◽  
Amit Kumar Nayak ◽  
Soumita Goswami
Keyword(s):  
Response Surface Methodology ◽  
Drug Release ◽  
Sustained Release ◽  
Response Surface ◽  
Diffusion Mechanism ◽  
Matrix Tablets ◽  
Fickian Diffusion ◽  
Order Model ◽  
Sustained Drug Release ◽  
Predicted Values

The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 23 factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release and hardness were analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized bisoprolol fumarate matrix tablets showed prolonged sustained release of bisoprolol fumarate over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.

LC-UV Method for Estimation of Drug Release from Carvacrol Loaded Nanobeads optimized by Response Surface Methodology

2020 ◽  
Vol 17 ◽  
Author(s):  
Pinal Talpada ◽  
Falguni Tandel
Keyword(s):  
Response Surface Methodology ◽  
Drug Release ◽  
Response Surface ◽  
Mobile Phase ◽  
Design Space ◽  
Limit Of Detection ◽  
Robust Method ◽  
Topical Formulation ◽  
Limit Of Quantitation

Aims: RP-HPLC-UV method was developed and validated for estimation of Carvacrol release rom Carvacrol loaded nanobeads through study of interaction between method parameters on method responses by Response Surface Methodology (RSM). Background: Literature review reveals that there is no validated analytical method for determining drug release of Carvacrol loaded nanobeads. Objective: The main objective of the research is to develop a novel robust method for estimation of carvacrol in drug release sample by applying RSM. Objective is to study the effect /interaction of method parameters like mobile phase ratio, pH and flowrate to the method output/response such as retention time, peak area, tailing factor, theoretical plates. To develop the design space and set the limit for all the method parameter is another objective. Finally the optimized method would be validated as per ICH Q2(R1)guideline for parameters like accuracy, specificity, precision, robustness, limit of detection, limit of quantitation. Methods: HPLC method was optimized by RSM approach using Design of Expert software. Box behnken design was applied using three factors and four responses.17 trials as per RSM were performed and final optimised LC method was selected based on design space. LC-UV method was validated as per ICH Q2 (R1) guideline. Drug release study was performed at pH 7.2 and pH 8. Results: Mobile phase finalised was Tetrahydrofuran: Acetonitrile: Water: Triethylamine (70:18:12:1 %v/v) having pH 6.5 adjusted with glacial acetic acid. Chromatographic column used was C18, 5µm particle size. Carvacrol was detected at 275nm and 1 mL/min flow rate. In-vitro drug release of Carvacrol from topical formulation is performed in a Franz diffusion cell. Drug release at pH 7.2 was found to be 82.8689 which is less than 90.1664 in phosphate buffer pH 8 at 24 hours. Conclusion: RSM was useful to minimize the experimental trials, study the interaction of method variation with method responses and give design space for robust method. Method was proved to be precise, specific, accurate and robust and suitable for Carvacrol release estimation.

scholarly journals Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology

2014 ◽  
Vol 50 (3) ◽  
pp. 493-504 ◽  
Author(s):  
Ikrima Khalid ◽  
Mahmood Ahmad ◽  
Muhammad Usman Minhas ◽  
Muhammad Sohail
Keyword(s):  
Response Surface Methodology ◽  
Controlled Release ◽  
Drug Release ◽  
Response Surface ◽  
Release Profile ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Direct Compression ◽  
Response Variables

The objective of the current study was to formulate mucoadhesive controlled release matrix tablets of flurbiprofen and to optimize its drug release profile and bioadhesion using response surface methodology. Tablets were prepared via a direct compression technique and evaluated for in vitro dissolution parameters and bioadhesive strength. A central composite design for two factors at five levels each was employed for the study. Carbopol 934 and sodium carboxymethylcellulose were taken as independent variables. Fourier transform infrared (FTIR) spectroscopy studies were performed to observe the stability of the drug during direct compression and to check for a drug-polymer interaction. Various kinetic models were applied to evaluate drug release from the polymers. Contour and response surface plots were also drawn to portray the relationship between the independent and response variables. Mucoadhesive tablets of flurbiprofen exhibited non-Fickian drug release kinetics extending towards zero-order, with some formulations (F3, F8, and F9) reaching super case II transport, as the value of the release rate exponent (n) varied between 0.584 and 1.104. Polynomial mathematical models, generated for various response variables, were found to be statistically significant (P<0.05). The study also helped to find the drug's optimum formulation with excellent bioadhesive strength. Suitable combinations of two polymers provided adequate release profile, while carbopol 934 produced more bioadhesion.

scholarly journals Effect of Hydroxypropyl Methylcellulose and Microcrystalline Cellulose in Design and Optimization of Nebivolol Hydrochloride Immediate Release Tablets by Response Surface Methodology

2021 ◽  
Vol 12 (3) ◽  
pp. 1990-1998
Author(s):  
Ramu Samineni ◽  
Jithendra Chimakurthy ◽  
Sathish Kumar Konidala ◽  
Udayaratna K ◽  
Devatulasi K ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Drug Release ◽  
Response Surface ◽  
Microcrystalline Cellulose ◽  
Hydroxypropyl Methylcellulose ◽  
Immediate Release ◽  
Wet Granulation ◽  
Weight Variation ◽  
Nebivolol Hydrochloride

The goal of the research is to design and optimize Nebivolol Hydrochloride immediate-release tablet using response surface methodology. Nebivolol Hydrochloride immediate-release tablets used in the treatment of heart attacks, myocardial infarction. Response surface methodology calculations for this optimization study were performed utilizing Minitab 17. Different formulations of immediate-release were prepared by applying 2 factors 3 levels full factorial design using Minitab 17, which gave 9 formulations by using the wet granulation method. Independent variables like the amount of hydroxypropyl methylcellulose (X1), and microcrystalline cellulose (X2) and dependent variables like the per cent drug release at 45 minutes (Y1), disintegration (Y2) were selected for optimization. The prepared batches of Nebivolol Hydrochloride immediate-release tablets were evaluated for the pre-compression and post-compression parameters like weight variation, thickness, hardness, and friability, disintegration, and in-vitro drug release studies. All the Physico-chemical parameters were found satisfactory for prepared tablets. The optimized formulation F7 showed disintegrated in 83 sec, percentage dissolution release 97.85 at the end of 45th minute. The results shows that formulated immediate-release tablets of Nebivolol HCl were better to meet patient compliance with respect to effectiveness.

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