Abstract
Background: Mindfulness interventions are effective at improving psychological distress and quality of life in cancer patients. Few mindfulness programs for cancer recovery exist in major cities throughout the Southeastern United States. The primary objective of this study was to assess the feasibility of a modified mindfulness-based stress reduction (MBSR) program for breast cancer patients in Birmingham, Alabama. The secondary objective was to estimate the effectiveness of the modified program by examining changes in patients’ mindfulness skills and quality of life. Methods: This study was a prospective, quasi-experimental feasibility study conducted over 10 months within a university hospital in Birmingham, Alabama. Feasibility was achieved if 80% of eligible patients screened chose to enroll in the study and 70% of enrolled patients attended all 8 program sessions. Program effectiveness was estimated by changes in mindfulness and quality of life indicators. These indicators were measured by validated scales administered at pretest, posttest, and 8-week follow-up and assessed with a non-parametric Friedman test. The program curriculum followed a modified version of Dr. Jon Kabat-Zinn’s MBSR program. Program sessions included sitting meditation, hatha/restorative yoga, and a body-focused attention practice called body scan. There were 3 groups of 2-5 patients.Results: The sample consisted of 12 patients. Forty-four percent (12/27) of eligible patients enrolled in the study, failing to meet recruitment success criteria of 80%; two out of 12 enrolled patients completed all 8 program sessions, resulting in 16.7% (2/12) retention, which fell below the retention success criteria of 70%. However, more than half (66.7%) of participants completed at least 7 sessions. Between baseline and 8-week follow-up, patients demonstrated statistically significant improvements in distress, general wellbeing, and fatigue-related quality of life.Conclusions: Feasibility objectives were not achieved. However, a large majority of participants (66.7%) completed 7 of the 8 program sessions. Program effectiveness was promising for distress, fatigue, and wellbeing. Results warrant further research on MBSR programs for breast cancer patients in Alabama. Future programs should investigate how to increase overall recruitment numbers, focusing on introducing mindfulness concepts to inexperienced populations. Studies should consider hosting sessions in community locations or via telemedicine to improve accessibility.
122MO Quality of life from the Penelope-B study on high-risk HR+/HER2- early breast cancer patients treated with endocrine therapy with or without palbociclib