scholarly journals Selection of antibiotic resistance at very low antibiotic concentrations

2014 ◽  
Vol 119 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Linus Sandegren
Keyword(s):  
Antibiotic Resistance ◽  
Selection Of

scholarly journals Potential impact of biocide adaptation on selection of antibiotic resistance in bacterial isolates

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Engy Elekhnawy ◽  
Fatma Sonbol ◽  
Ahmed Abdelaziz ◽  
Tarek Elbanna
Keyword(s):  
Antibiotic Resistance ◽  
Cross Resistance ◽  
Main Body ◽  
Bacterial Isolates ◽  
New Agents ◽  
Biocidal Products ◽  
Potential Impact ◽  
Emergence Of Resistance ◽  
Vital Factor ◽  
Selection Of

Abstract Background Antibiotic resistance in pathogenic bacterial isolates has increased worldwide leading to treatment failures. Main body Many concerns are being raised about the usage of biocidal products (including disinfectants, antiseptics, and preservatives) as a vital factor that contributes to the risk of development of antimicrobial resistance which has many environmental and economic impacts. Conclusion Consequently, it is important to recognize the different types of currently used biocides, their mechanisms of action, and their potential impact to develop cross-resistance and co-resistance to various antibiotics. The use of biocides in medical or industrial purposes should be monitored and regulated. In addition, new agents with biocidal activity should be investigated from new sources like phytochemicals in order to decrease the emergence of resistance among bacterial isolates.

scholarly journals Selection of appropriate analytical tools to determine the potency and bioactivity of antibiotics and antibiotic resistance

2016 ◽  
Vol 6 (4) ◽  
pp. 207-213 ◽  
Author(s):  
Nishant A. Dafale ◽  
Uttam P. Semwal ◽  
Rupak K. Rajput ◽  
G.N. Singh
Keyword(s):  
Antibiotic Resistance ◽  
Analytical Tools ◽  
Selection Of

Selection of antibiotic resistance by metals in a riverine bacterial community

Chemosphere ◽  
2021 ◽  
Vol 263 ◽  
pp. 127936
Author(s):  
Isabel Silva ◽  
Marta Tacão ◽  
Isabel Henriques
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Community ◽  
Selection Of

scholarly journals Potential risks of antibiotic resistant bacteria and genes in bioremediation of petroleum hydrocarbon contaminated soils

2020 ◽  
Vol 22 (5) ◽  
pp. 1110-1124 ◽  
Author(s):  
Colin J. Cunningham ◽  
Maria S. Kuyukina ◽  
Irena B. Ivshina ◽  
Alexandr I. Konev ◽  
Tatyana A. Peshkur ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Contaminated Soil ◽  
Contaminated Soils ◽  
Petroleum Hydrocarbon ◽  
Resistant Bacteria ◽  
Careful Selection ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Potential Risks ◽  
Selection Of

The problems associated with potential risks of antibiotic resistance spreading during bioremediation of oil-contaminated soil are discussed. Careful selection of bacterial strains and pretreatment of organic wastes used as fertilizers are suggested.

scholarly journals Selection for antibiotic resistance is reduced when embedded in a natural microbial community

2019 ◽  
Author(s):  
Uli Klümper ◽  
Mario Recker ◽  
Lihong Zhang ◽  
Xiaole Yin ◽  
Tong Zhang ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Microbial Community ◽  
Single Species ◽  
Natural Environments ◽  
Order Of Magnitude ◽  
Natural Microbial Community ◽  
Cost Of Resistance ◽  
Selection For ◽  
The Cost ◽  
Selection Of

AbstractAntibiotic resistance has emerged as one of the most pressing, global threats to public health. In single-species experiments selection for antibiotic resistance occurs at very low antibiotic concentrations. However, it is unclear how far these findings can be extrapolated to natural environments, where species are embedded within complex communities. We competed isogenic strains of Escherichia coli, differing exclusively in a single chromosomal resistance determinant, in the presence and absence of a pig fecal microbial community across a gradient of antibiotic concentration for two relevant antibiotics: gentamicin and kanamycin. We show that the minimal selective concentration was increased by more than one order of magnitude for both antibiotics when embedded in the community. We identified two general mechanisms were responsible for the increase in minimal selective concentration: an increase in the cost of resistance and a protective effect of the community for the susceptible phenotype. These findings have implications for our understanding of the evolution and selection of antibiotic resistance, and can inform future risk assessment efforts on antibiotic concentrations.

scholarly journals A Strategy for Hospital Pharmacists to Control Antimicrobial Resistance (AMR) in Japan

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1284
Author(s):  
Yukihiro Hamada ◽  
Fumiya Ebihara ◽  
Ken Kikuchi
Keyword(s):  
Antibiotic Resistance ◽  
Therapeutic Drug Monitoring ◽  
Antimicrobial Stewardship ◽  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Action Plan ◽  
Therapeutic Drug ◽  
Optimal Selection ◽  
Inappropriate Use ◽  
Selection Of

In Japan, there is concern regarding the relation between the inappropriate use of antibiotics and antibiotic resistance (AMR). Increased bacterial resistance is due in part to the inappropriate use of antimicrobial agents. The support of the pharmacist becomes important, and there is growing interest in antimicrobial stewardship to promote the appropriate and safe use of antimicrobials needed for the optimal selection of drugs, doses, durations of therapy, therapeutic drug monitoring (TDM), and implementations of cost containment strategies in Japan. Pharmacists should strive to disseminate the concept of “choosing wisely” in relation to all medicines, implement further interventions, and put them into practice. In this article, we present data for antimicrobial stewardship and Japan’s AMR action plan, focusing on how pharmacists should be involved in enabling physicians to choose antimicrobials wisely.

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