Estimation of Population Pharmacokinetic Parameters Using Destructively Obtained Experimental Data: A Simulation Study of the One-Compartment Open Model

1984 ◽  
Vol 15 (1-2) ◽  
pp. 195-264 ◽  
Author(s):  
F. Tom Lindstrom ◽  
David S. Birkes
Keyword(s):  
Experimental Data ◽  
Simulation Study ◽  
Pharmacokinetic Parameters ◽  
Population Pharmacokinetic ◽  
Open Model ◽  
The One ◽  
Compartment Open Model

Ketamine kinetics: decerebrate vs. intact cats

1979 ◽  
Vol 57 (8) ◽  
pp. 878-881 ◽  
Author(s):  
James E. Heavner ◽  
Duane C. Bloedow
Keyword(s):  
Apparent Volume ◽  
Volume Of Distribution ◽  
Drug Dose ◽  
The Body ◽  
Pharmacokinetic Parameters ◽  
Peripheral Compartment ◽  
Blood Concentrations ◽  
Open Model ◽  
Apparent Volume Of Distribution ◽  
Compartment Open Model

Pharmacokinetic parameters of a ketamine (10 mg/kg, iv) bolus in decerebrate and intact cats were compared. A two-compartment open model best described the data in both groups. The apparent volume of distribution of the peripheral compartment, the apparent volume of distribution of the drug in the body, and the half-life of the postdistributive phase were significantly less (p < 0.05) in the decerebrate animals. These results emphasize the importance of correlating behavior and neuronal activity with plasma or blood concentrations of drug in animals rather than assuming that, for a given drug dose, blood (and thus tissue) levels of the agent will be similar regardless of how the animal is prepared for study.

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