Physical-Chemical Factors Affecting the Preparation of a Coarse Solid Dispersion by Crystallization of Indowhacin from a Metastable Solid Solution

1976 ◽  
Vol 2 (4-5) ◽  
pp. 359-376 ◽  
Author(s):  
J. C. Saboe ◽  
R. E. Dempski
2019 ◽  
Vol 3 (1) ◽  
pp. 275-286
Author(s):  
Sarvenaz Bigham ◽  
Behrouz Zarei Darki ◽  
Rahman Patimar ◽  
Eisa Jorjani

Atomic Energy ◽  
2000 ◽  
Vol 88 (1) ◽  
pp. 42-47 ◽  
Author(s):  
V. K. Orlov ◽  
V. M. Teplinskaya ◽  
N. T. Chebotarev

1934 ◽  
Vol 25 (4) ◽  
pp. 491-494 ◽  
Author(s):  
P. A. Buxton

During the last decade, entomologists have made progress in understanding the environment in which certain insects live; in particular, we begin to understand the effect of certain physical and chemical factors, which make up a part of the environment. With this gain in knowledge, it is sometimes possible to forecast outbreaks of insects and of diseases conveyed by them, and one can sometimes say that a particular alteration of the environment will result in loss or gain. But so far as mosquitos are concerned, one must admit that though much work has been devoted to the analytical study of the water in which the early stages are passed, the results are disappointing. A consideration of the published work suggests several reasons for this. Investigation into the ecology of the mosquito has had a vogue, and much of it has been done by workers who were isolated and whose knowledge of chemical technique and freshwater biology was limited. Apart from that, the inherent difficulties are great, for the worker must hunt for the limiting chemical and physical factors among a host of others which are doubtless unimportant, and there are few clues to indicate which of the chemical constituents of the water affects the mosquito. The data are therefore voluminous and it is difficult to reduce them to order and present them so that they can be readily understood.


1981 ◽  
Vol 7 ◽  
Author(s):  
G. Battaglin ◽  
A. Carnera ◽  
G. Della Mea ◽  
P. Mazzoldi ◽  
Animesh K. Jain ◽  
...  

ABSTRACTWe present a comparative study (by 1.8 MeV 4He+ ion channeling) of virgin, self and Eu implanted single crystals of nickel, under irradiation with single ruby laser pulses. The as implanted Eu is nearly non-substitutional and remains so, even after laser treatment. The comparative defect dechanneling behaviour provides explicit evidence of defect-impurity interaction which may be suppressing the formation of an expected metastable solid solution in the Eu-Ni system, which possesses miscibility in the liquid phase. A clear surface Eu peak appears at 2.1 J/cm2.


Author(s):  
Sandeep Kumar Vats ◽  
Roop Narayan Gupta ◽  
Kalaiselvan Ramaraju ◽  
Romi Singh

<p><strong>Objective: </strong>To study the mechanism and factors affecting the design of an industrially scalable formulation in a combined drug delivery module containing solid dispersion (SD) multiunit pellets with novel polymer Soluplus® in a modified release system to address chronotherapeutic needs of hypertension therapy.</p><p><strong>Methods: </strong>Nisoldipine-Soluplus® SD pellet formulations were prepared using the central composite design of experiments (CCD) to study the effect of inert core level and drug to polymer ratio. The solid dispersions were formed on inert pellets surface by fluidized bed coating and characterized by dissolution efficiency and time for 90% drug release. The data was statistically analyzed to develop a response surface for optimum SD formulation in pellets. The SD pellets were characterized by FTIR, DSC and SEM. The optimum formulation of SD coated pellets was further coated with Eudragit S100-L100 polymer mix and characterized for dissolution in multimedia and two-step dissolution for lag time.</p><p><strong>Results: </strong>A response surface was developed for highest dissolution efficiency (%DE) and least time to release 90% drug (T<sub>90</sub>). The model was significant, and the role of core pellets was found to be more significant than the drug-polymer ratio. The study of the desirability function indicated that a polymer content of 75% and inert core level to yield 23% net weight gain, provided optimum dissolution enhanced SD pellets. The drug was found to exist in amorphous form. The final capsules containing Eudragit S100-L100 coated delayed release SD pellets showed a lag time of 2 h and a definite pH-gradient towards drug release.</p><p><strong>Conclusion: </strong>The findings from this study helped to understand the mechanism, design and factors affecting drug release from a delayed release SD system for a poorly soluble drug for potential hypertension chronotherapy.</p>


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