Exendin-4 Protects Murine Pancreatic β-Cells from Free Fatty Acid-Induced Apoptosis Through PI-3K Signaling

2012 ◽  
Vol 38 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Liang Liu ◽  
Yanping Wang ◽  
Linxi Wang ◽  
Yichuan Lin ◽  
Xiaohong Liu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Induced Apoptosis

scholarly journals PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e50128 ◽  
Author(s):  
Hyo-Sup Kim ◽  
You-Cheol Hwang ◽  
Seung-Hoi Koo ◽  
Kyong Soo Park ◽  
Myung-Shik Lee ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Acid Receptor ◽  
Ppar Γ ◽  
Free Fatty Acid Receptor ◽  
Fatty Acid Receptor

Troglitazone does not protect rat pancreatic β cells against free fatty acid-induced cytotoxicity

2002 ◽  
Vol 63 (7) ◽  
pp. 1281-1285 ◽  
Author(s):  
Miriam Cnop ◽  
Jean Claude Hannaert ◽  
Daniel G. Pipeleers
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Β Cells ◽  
Pancreatic Β Cells

Discovery of a novel oxime ether scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists

RSC Advances ◽  
2016 ◽  
Vol 6 (52) ◽  
pp. 46356-46365 ◽  
Author(s):  
Zheng Li ◽  
Jianyong Yang ◽  
Weijie Gu ◽  
Guoshen Cao ◽  
Xiaoting Fu ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Acid Receptor ◽  
Free Fatty Acid Receptor ◽  
Orally Bioavailable ◽  
Glucose Stimulated Insulin Secretion ◽  
Fatty Acid Receptor

The free fatty acid receptor 1 (FFA1) plays a key role in amplifying glucose-stimulated insulin secretion in pancreatic β-cells.

scholarly journals Metabolic consequence of long-term exposure of pancreatic β cells to free fatty acid with special reference to glucose insensitivity

2002 ◽  
Vol 1586 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Katsumi Iizuka ◽  
Hiromu Nakajima ◽  
Mitsuyoshi Namba ◽  
Jun-ichiro Miyagawa ◽  
Junichi Miyazaki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Special Reference ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Metabolic Consequence

ER stress attenuation by Aloe-derived polysaccharides in the protection of pancreatic β-cells from free fatty acid-induced lipotoxicity

2018 ◽  
Vol 500 (3) ◽  
pp. 797-803 ◽  
Author(s):  
Kisoo Kim ◽  
Min Hwa Chung ◽  
Soyoung Park ◽  
Jimin Cha ◽  
Jin Hong Baek ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Er Stress ◽  
Β Cells ◽  
Pancreatic Β Cells
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