Effect of time and duration of untreated psychosis on cognitive and social functioning in Chinese patients with first-episode schizophrenia: A 1-year study

2015 ◽  
Vol 69 (4) ◽  
pp. 254-261 ◽  
Author(s):  
Anisha Heeramun-Aubeeluck ◽  
Na Liu ◽  
Felix Fischer ◽  
Nan Huang ◽  
Fazhan Chen ◽  
...  
Keyword(s):  
Social Functioning ◽  
Chinese Patients ◽  
First Episode ◽  
Duration Of Untreated Psychosis ◽  
First Episode Schizophrenia

Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset

2015 ◽  
Vol 30 (8) ◽  
pp. 995-1001 ◽  
Author(s):  
S. Ito ◽  
T. Nemoto ◽  
N. Tsujino ◽  
N. Ohmuro ◽  
K. Matsumoto ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Social Functioning ◽  
First Episode ◽  
Duration Of Untreated Psychosis ◽  
Prospective Longitudinal Study ◽  
Insidious Onset ◽  
First Episode Schizophrenia ◽  
Prospective Longitudinal ◽  
Onset Group

AbstractBackgroundThe mode of onset and the course of schizophrenia illness exhibit substantial individual variations. Previous studies have pointed out that the mode of onset affects the duration of untreated psychosis (DUP) and clinical outcomes, such as cognitive and social functioning. This study attempted to clarify the association between the DUP and clinical features, taking the different modes of onset into consideration, in a prospective longitudinal study examining patients with first-episode schizophrenia.MethodsThis study was conducted in six areas of Japan. Patients with first-episode schizophrenia were followed for over 18 months. Cognitive function, psychopathology, and social functioning were assessed at baseline and at 6, 12, and 18-month follow-up points.ResultsWe identified 168 patients and sufficient information was available to determine the DUP and the mode of onset for 156 patients (92.9%): 79 had an acute onset, and 77 had an insidious onset. The DUP was significantly associated with quality of life (QOL), social functioning, and cognitive function at most of the follow-up points in the insidious-onset group. The DUP and negative symptoms at baseline were significant predictors of cognitive function at the 18-month follow-up in the insidious-onset group.ConclusionsThe present results further support the hypothesis that the DUP affects QOL, social functioning, and cognitive function over the course of illness, especially in patients with an insidious onset. Effective strategies for detecting and caring for individuals with insidious onset early during the course of schizophrenia will be essential for achieving a full patient recovery.

Arginine vasopressin improves the memory deficits in Han Chinese patients with first-episode schizophrenia

Peptides ◽  
2017 ◽  
Vol 97 ◽  
pp. 8-15 ◽  
Author(s):  
Cai-Hong Geng ◽  
Chao Wang ◽  
Jun Yang ◽  
Hua Wang ◽  
Rui-Qing Ma ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Memory Deficits ◽  
Han Chinese ◽  
Chinese Patients ◽  
First Episode ◽  
First Episode Schizophrenia

scholarly journals Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia

2008 ◽  
Vol 193 (3) ◽  
pp. 203-209 ◽  
Author(s):  
Thomas R. E. Barnes ◽  
Verity C. Leeson ◽  
Stanley H. Mutsatsa ◽  
Hilary C. Watt ◽  
Sam B. Hutton ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Social Function ◽  
First Episode ◽  
Duration Of Untreated Psychosis ◽  
Clinical Difference ◽  
Path Analyses ◽  
First Episode Schizophrenia ◽  
The Relationship ◽  
Positive And Negative Symptoms

BackgroundIn first-episode schizophrenia, longer duration of untreated psychosis (DUP) predicts poorer outcomes.AimsTo address whether the relationship between DUP and outcome is a direct causal one or the result of association between symptoms and/or cognitive functioning and social functioning at the same time point.MethodSymptoms, social function and cognitive function were assessed in 98 patients with first-episode schizphrenia at presentation and 1 year later.ResultsThere was no significant clinical difference between participants with short and long DUP at presentation. Linear regression analyses revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation. Path analyses revealed independent direct relationships between DUP and social function, core negative symptoms and positive symptoms. There was no significant association between DUP and cognition.ConclusionsLonger DUP predicts poor social function independently of symptoms. The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP.

scholarly journals Duration of untreated psychosis and pathways to psychiatric services in first-episode schizophrenia

2004 ◽  
Vol 58 (1) ◽  
pp. 76-81 ◽  
Author(s):  
RYOKO YAMAZAWA ◽  
MASAFUMI MIZUNO ◽  
TAKAHIRO NEMOTO ◽  
YUTA MIURA ◽  
MASAAKI MURAKAMI ◽  
...  
Keyword(s):  
Psychiatric Services ◽  
First Episode ◽  
Duration Of Untreated Psychosis ◽  
First Episode Schizophrenia

Duration of untreated psychosis may predict acute treatment response in first-episode schizophrenia

2004 ◽  
Vol 38 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Alp Üçok ◽  
Aslιhan Polat ◽  
Aysun Genç ◽  
Sibel Çakιr ◽  
Nurten Turan
Keyword(s):  
Treatment Response ◽  
Acute Treatment ◽  
First Episode ◽  
Duration Of Untreated Psychosis ◽  
First Episode Schizophrenia
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