Efficacy of Low Dose Prednisone Plus Aspirin in Preventing Spontaneous Abortions and/or Fetal Deaths Due to Antiphospholipid Antibodies: Results of a Pilot Study

Autoimmunity ◽  
1996 ◽  
Vol 24 (2) ◽  
pp. 123-125 ◽  
Author(s):  
M. G. Mazzucconi ◽  
F. Dragoni ◽  
A. Chistolini ◽  
M. Peraino ◽  
R. Paesano ◽  
...  
Keyword(s):  
Pilot Study ◽  
Antiphospholipid Antibodies ◽  
Low Dose ◽  
Spontaneous Abortions ◽  
Dose Prednisone

scholarly journals Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jiaming Li ◽  
Zhaoyue Wang ◽  
Lan Dai ◽  
Lijuan Cao ◽  
Jian Su ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Low Dose ◽  
Group Versus ◽  
Treg Cells ◽  
Significant Rise ◽  
Control Group ◽  
Foxp3 Mrna ◽  
Experimental Group ◽  
Dose Prednisone ◽  
Chronic Immune Thrombocytopenia

We conducted this randomized trial to investigate the efficacy and safety of rapamycin treatment in adults with chronic immune thrombocytopenia (ITP). Eighty-eight patients were separated into the control (cyclosporine A plus prednisone) and experimental (rapamycin plus prednisone) groups. The CD4+CD25+CD127lowregulatory T (Treg) cells level, Foxp3 mRNA expression, and the relevant cytokines levels were measured before and after treatment. The overall response (OR) was similar in both groups (experimental group versus control group: 58% versus 62%,P=0.70). However, sustained response (SR) was more pronounced in the experimental group than in the control group (68% versus 39%,P<0.05). Both groups showed similar incidence of adverse events (7% versus 11%,P=0.51). As expected, the low pretreatment baseline level of Treg cells was seen in all patients (P<0.001); however, the experimental group experienced a significant rise in Treg cell level, and there was a strong correlation between the levels of Treg cells and TGF-beta after the treatment. In addition, the upregulation maintained a stable level during the follow-up phase. Thus, rapamycin plus low dose prednisone could provide a new promising option for therapy of ITP.

Safety of Low-Dose Heparin for Intracranial Stent-Assisted Angioplasty:A Randomized Controlled Pilot Study

2009 ◽  
Vol 16 (5) ◽  
pp. 642-648 ◽  
Author(s):  
Feng Gao ◽  
Bin Du ◽  
Xiao-Tong Xu ◽  
Yong-Jun Wang ◽  
Wei-Jian Jiang
Keyword(s):  
Pilot Study ◽  
Low Dose ◽  
Intracranial Stent ◽  
Randomized Controlled ◽  
Dose Heparin ◽  
Low Dose Heparin

Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study

Lupus ◽  
2000 ◽  
Vol 9 (9) ◽  
pp. 688-695 ◽  
Author(s):  
P R J Ames ◽  
C Tommasino ◽  
J Alves ◽  
J D Morrow ◽  
L Iannaccone ◽  
...  
Keyword(s):  
Pilot Study ◽  
Antiphospholipid Antibodies

scholarly journals Is mycophenolate mofetil combined with low-dose prednisone a treatment option for advanced IgA nephropathy? A 10-year follow-up case and brief literature review

2018 ◽  
Vol 16 ◽  
pp. 205873921880268
Author(s):  
Qijun Wan ◽  
Yongcheng He ◽  
Hongtao Chen ◽  
Hongping Liu ◽  
Saodong Luan ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Iga Nephropathy ◽  
Treatment Option ◽  
Low Dose ◽  
Interstitial Fibrosis ◽  
Immunosuppressive Treatment ◽  
Channel Blockers ◽  
Tubular Atrophy ◽  
Dose Prednisone

IgA nephropathy (IgAN) is now widely recognized as the most common primary glomerulonephritis worldwide, especially in China. The immunosuppressive treatment option for IgAN is still controversial. Previously, we proved that mycophenolate mofetil (MMF; Shanghai Roche, China) combined with low-dose prednisone was an effective and safe option for biopsy-proven mild to moderate IgAN patients in a short term of follow-up. This article we first reported the safety and efficacy of this regimen in a 42-year-old male biopsy-proven advanced 10-year follow-up IgAN case (Lee’s Class V; the patient was biopsied 10 years ago, so the Oxford Mesangial hypercellularity Endocapillary hypercellularity Segmental glomerulosclerosis Tubular atrophy/interstitial fibrosis (MEST) classification was not used). The mycophenolate and prednisone were only given for a limited time. The other main medications included calcium channel blockers and antiplatelet agents. Clinical and laboratory indexes were aperiodic assessed during the 10-year follow-up. The serum creatinine decreased from 356 to around 210 μmol/L and urine excretion protein reduced from 3.4 g/d to about 0.5 g/d after 6 months of the initiation of this regimen, respectively. These perfect treatment effects could maintain well during the whole follow-up period. No obvious complications were observed.

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