Development of a novel vesicular system using a binary mixture of sorbitan monostearate and polyethylene glycol fatty acid esters for rectal delivery of rutin

Abstract A method is described for gas chromatographic (GC) determination of sorbitan fatty acid esters in confectionery products as sorbitan monostearate. A sample is homogenized with chloroform, filtered, dried, and saponified with 0.1N NaOH in ethanol 1 h at 80°C. The saponification mixture is acidified, washed with hexane, and dried. Isosorbide, 1,4-sorbitan, and D-sorbitol are each derivatized at 70°C with pyridine, hexamethyldisilazane, and trimethylchlorosilane. GC separation of the polyols as TMS (trimethylsilyl) derivatives was performed on a 2% Dexsil 300 column temperature-programmed from 120 to 250°C at 107 min. The sorbitan monostearate content of the sample was calculated from the polyols, using the appropriate conversion factor. The procedure was applied to ice creams, cakes, and other confectionery products. Average recoveries from samples spiked with 1.0% Span 60 (sorbitan monostearate) were 91-96% for isosorbide, 83-99% for 1,4-sorbitan, and 82-98% for D-sorbitol. The detection limit was approximately 0.01%.

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Development of the determination methods of fatty acid esters of chloropropanediols in fat-rich foods

Chinese Journal of Chromatography ◽

10.3724/sp.j.1123.2012.09002 ◽

2014 ◽

Vol 31 (2) ◽

pp. 95-101

Author(s):

Xiaobo YAN ◽

Shaoming WU ◽

Nan LI ◽

Huadong LV ◽

Wusheng FU

Keyword(s):

Fatty Acid ◽

Fatty Acid Esters ◽

Determination Methods ◽

Acid Esters

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Mesomorphic Behaviour of Saturated and Monounsaturated C18 and C22 Fatty Acid Esters of Cholesterol

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19940833 ◽

1994 ◽

Vol 59 (4) ◽

pp. 833-840

Author(s):

Slavomír Pirkl

Keyword(s):

Phase Transitions ◽

Fatty Acid ◽

Fatty Acid Esters ◽

Aliphatic Esters ◽

Acid Esters

The phase transitions and effective optical rotary power of saturated and monounsaturated aliphatic esters of cholesterol with 18 and 22 carbon atoms in the chain have been described. The effect of cis/trans isomerism on these properties is discussed.

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The occurrence of long chain polyprenols in leaves of plants of Rosaceae family and their isolation by time-extended liquid chromatography

Biochemistry and Cell Biology ◽

10.1139/o92-068 ◽

1992 ◽

Vol 70 (6) ◽

pp. 448-454 ◽

Cited By ~ 9

Author(s):

Ewa Świeżewska ◽

T. Chojnacki ◽

W. J. Jankowski ◽

K. Singh ◽

J. Olsson

Keyword(s):

Liquid Chromatography ◽

Fatty Acid ◽

Large Scale ◽

Fatty Acid Esters ◽

Large Scale Preparation ◽

Scale Preparation ◽

Wet Weight ◽

Rosaceae Family ◽

Acid Esters ◽

Long Chain

The long chain polyprenols composed of 30 and more isoprene units from leaves of plants belonging to the genera Potentilla and Rosa have been described. They occur in the form of fatty acid esters. The composition of polyprenol mixture was species dependent and its content reached ca. 0.5% wet weight. Large scale preparation of individual polyprenols from a natural polyprenol mixture was performed using time-extended liquid chromatography on the hydrophobic gel Lipidex-5000.Key words: long chain polyprenols, Rosaceae.

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Separation of Fatty Acid Dimethyl Esters on an Ionic Liquid Gas Chromatographic Column

Journal of Chromatographic Science ◽

10.1093/chromsci/bmaa097 ◽

2020 ◽

Author(s):

R E Pauls ◽

B Pease

Keyword(s):

Ionic Liquid ◽

Fatty Acid ◽

Stationary Phases ◽

Carbon Number ◽

Fatty Acid Esters ◽

Reaction Products ◽

Isomer Separation ◽

Metathesis Reaction ◽

Polydimethyl Siloxane ◽

Acid Esters

Abstract An ionic liquid (IL) 111 column was compared with other commonly employed stationary phases including polydimethyl siloxane and polyethylene glycol for the separation of fatty acid monomethyl and dimethyl esters. The fatty acid esters employed in this study were derived from metathesis reactions of vegetable oils both with and without olefins. The IL 111 column demonstrated enhanced performance compared with conventional columns for the separation of these esters. These advantages included significantly enhanced retention of dimethyl esters relative to monomethyl esters, excellent cis/trans isomer separation and the ability to analyze higher carbon number dimethyl esters. As a result, these columns are highly suited for the analysis of mixtures of mono- and dimethyl fatty acid esters found in lipid metathesis reaction products or to determine monofunctional impurities in samples of commercial dimethyl esters.

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