Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea

This article discusses the problem of drug interactions between combined oral contraceptives on the example of Belara® (30 μg of ethinyl estradiol + 2 mg of chlormadinone acetate; Gedeon Richter, Hungary) and medications recommended for the treatment of new coronavirus infection (COVID-19) and concomitant disorders at the pharmacodynamic and pharmacokinetic levels with an assessment of the efficacy and safety of therapy for females. We described safe, potentially dangerous, and dangerous combinations of these drugs. Key words: new coronavirus infection (CAVID-19), combined oral contraceptives, antiviral drugs, antibacterial drugs, antiinflammatory drugs, anticoagulants, migraine drugs, antihypertensive drugs, oral hypoglycemic drugs, essential micronutrients, pharmacodynamic and pharmacokinetic interactions

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The effects of two monophasic oral contraceptives containing 30 mcg of ethinyl estradiol and either 2 mg of chlormadinone acetate or 0.15 mg of desogestrel on lipid, hormone and metabolic parameters

Contraception ◽

10.1016/j.contraception.2008.08.011 ◽

2009 ◽

Vol 79 (1) ◽

pp. 15-23 ◽

Cited By ~ 31

Author(s):

Ulrich H. Winkler ◽

Roland Sudik

Keyword(s):

Oral Contraceptives ◽

Ethinyl Estradiol ◽

Metabolic Parameters ◽

Chlormadinone Acetate

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Decreased Levels of Histidine-Rich Glycoprotein (HRG) and Increased Levels of Free Plasminogen in Women on Oral Contraceptives Low in Estrogen

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657281 ◽

1982 ◽

Vol 48 (03) ◽

pp. 283-285 ◽

Cited By ~ 28

Author(s):

Jørgen Jespersen ◽

Cornelis Kluft

Keyword(s):

Oral Contraceptives ◽

Ethinyl Estradiol ◽

Relative Increase ◽

Normal Group ◽

Plasma Samples ◽

Normal Women ◽

Made In

SummaryDeterminations by immunologic methods of histidine-rich glycoprotein (HRG) and plasminogen, were made in plasma samples collected during one normal or hormone induced cycle in 15 young, normal women and in 11 women using oral contraceptives with 30 μg ethinyl estradiol and 150 μg levo-norgestrel. The hormone group showed an increase in plasminogen level to about 150% of normal, while the concentration of HRG was decreased to about 75% of normal. This resulted in a considerable relative increase in the concentration of free plasminogen in the hormone group (calculated from the equilibrium: HRG·plasminogen ⇌ HRG + plasminogen, using KD = 1.0 μM), representing a doubling of that in the normal group. Hence, more plasminogen is available for binding to fibrin and activation in the hormone group.

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Hormonal contraception as a method of social adaptation of women in modern society

GYNECOLOGY ◽

10.26442/20795696.2019.3.190593 ◽

2019 ◽

Vol 21 (3) ◽

pp. 17-21

Author(s):

Tatyana Yu Pestrikova ◽

Elena A Yurasova ◽

Igor V Yurasov ◽

Tamara D Kovaleva

Keyword(s):

Ethinyl Estradiol ◽

Hormonal Contraception ◽

Modern Society ◽

Well Being ◽

Social Adaptation ◽

Female Employment ◽

Hormonal Contraceptives ◽

Aim Analysis ◽

Positive Effects ◽

Chlormadinone Acetate

Relevance. Currently, women make up more than 40% of the global workforce and more than half of students studying at universities around the world. Women's education, especially at a high level, tends to increase female employment. The mismatch of the style and rhythm of modern life with a genetically determined and working millennium reproductive program requires the choice of a specific approach to social adaptation. Aim. Analysis of literary sources on the use of hormonal contraception as a method of social adaptation. Materials and methods. To write this review, domestic and foreign publications were searched in Russian and international search systems (PubMed, eLibrary, etc.) for the last 2-10 years. The review included articles from peer-reviewed literature. Results. The review describes the features of modern hormonal contraceptives. Their non-contraceptive effects are presented. The individual non-contraceptive effects of a combined oral contraceptive containing 30 mg of ethinyl estradiol and 2 mg of chlormadinone acetate were determined. It has been established that the use of this contraceptive helps to improve the well-being and mood of patients, which allows you to actively use this contraceptive in routine clinical practice with premenstrual syndrome, dysmenorrhea, without the use of analgesics. Conclusions. The numerous positive effects of ethinyl estradiol and chlormadinone acetate allow the use of the drug as a means to increase social adaptation, and, consequently, improve the quality of life.

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