Chronic exposure of Sprague-Dawley rats to 20 kHz triangular magnetic fields

The aim of the present study was to verify whether the oral administration of cyanidin 3-O-β-d-glucoside (C3G) might counteract damage induced by chronic exposure (28 d) to ochratoxin A (OTA) in rats and if its effect may be mediated by haeme oxygenase-1 (HO-1). Forty male Sprague–Dawley rats, individually caged, were divided into four groups of ten animals. A control group received a commercial diet, group C3G received the control diet supplemented with C3G (1 g/kg feed), group OTA received the control diet supplemented with 200 parts per billion of OTA, and group OTA+C3G received the OTA group diet supplemented with C3G (1 g/kg feed). After 4 weeks of treatment animals were killed and the liver, kidneys and brain of each rat were collected and homogenised to evaluate non-proteic thiol groups (RSH), lipid hydroperoxide (LOOH) levels, HO-1 expression and DNA fragmentation. Rats of the OTA group showed a significant (P < 0·001) decrease in RSH content of kidney and liver and a significant (P < 0·001) increase of LOOH in all the examined tissues compared with the control group. In the OTA+C3G group both RSH content and LOOH levels were similar to those observed in the control group, demonstrating that C3G was able to counteract the effects of OTA. A significant (P < 0·001) induction of HO-1 was evident in kidney and liver of both OTA and C3G groups. DNA damage occurred in all the examined tissues of the OTA group, whereas C3G was able to prevent it. The present study confirmed that the effects of OTA are mediated by oxidative stress and demonstrated that C3G efficiently counteracted deleterious effects of OTA because of its antioxidant and HO-1-inducing properties.

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Acute and Chronic Exposure to Phytoestrogens Modulates Testosterone Concentrations and Testis Morphology in Sprague-Dawley Rats.

Biology of Reproduction ◽

10.1093/biolreprod/81.s1.645 ◽

2009 ◽

Vol 81 (Suppl_1) ◽

pp. 645-645

Author(s):

Justin M. Jacobson ◽

Monika G. Baldridge

Keyword(s):

Chronic Exposure ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Acute And Chronic Exposure

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Evaluation of the Developmental Toxicity of 60 Hz Magnetic Fields and Harmonic Frequencies in Sprague-Dawley Rats

Radiation Research ◽

10.1667/0033-7587(2000)153[0637:eotdto]2.0.co;2 ◽

2000 ◽

Vol 153 (5) ◽

pp. 637-641 ◽

Cited By ~ 7

Author(s):

Bernadette M. Ryan ◽

Mary Polen ◽

James R. Gauger ◽

Eddie Mallett, Jr. ◽

Mark B. Kearns ◽

...

Keyword(s):

Magnetic Fields ◽

Developmental Toxicity ◽

Sprague Dawley ◽

Harmonic Frequencies ◽

Sprague Dawley Rats

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Black tea and curcumin synergistically mitigate the hepatotoxicity and nephropathic changes induced by chronic exposure to aflatoxin‐B1 in Sprague–Dawley rats

Journal of Food Biochemistry ◽

10.1111/jfbc.13346 ◽

2020 ◽

Vol 44 (9) ◽

Author(s):

Haitham I. El‐Mekkawy ◽

Mohammed A. Al‐Kahtani ◽

Ali A. Shati ◽

Mohammed A. Alshehri ◽

Amin A. Al‐Doaiss ◽

...

Keyword(s):

Aflatoxin B1 ◽

Chronic Exposure ◽

Black Tea ◽

Sprague Dawley ◽

Sprague Dawley Rats

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Effect of Chronic Exposure to Dexamethasone on Rocuronium-induced Neuromuscular Blockade and Sugammadex Reversal: an in Vivo Study on Rats

10.21203/rs.3.rs-955941/v1 ◽

2021 ◽

Author(s):

Ha Yeon Park ◽

Heyran Choi ◽

Yong Beom Kim ◽

Seok Kyeong Oh ◽

Taehoon Kim ◽

...

Keyword(s):

Neuromuscular Blockade ◽

Chronic Exposure ◽

Recovery Time ◽

Medical Center ◽

Control Group ◽

Sprague Dawley ◽

Dexamethasone Group ◽

Sprague Dawley Rats ◽

Train Of Four

Abstract Background: Chronic exposure to glucocorticoids is associated with resistance to nondepolarising neuromuscular blocking agents. Therefore, we hypothesised that sugammadex-induced recovery in subjects with chronic exposure to dexamethasone was faster than that in subjects without dexamethasone exposure. Objective: To evaluate the recovery profile of rocuronium-induced neuromuscular blockade after sugammadex administration in rats. Design: An in vivo study on rats.Setting: Asan Institute for Life Sciences, Asan Medical Center, Korea, from April 2017 to October 2017.Animals: Thirty-six male Sprague-Dawley rats.Intervention: Sprague–Dawley rats were allocated to three groups (dexamethasone group, control group, and pair-fed group) for the in vivo study. Dexamethasone group received daily intraperitoneal injections of dexamethasone 500 μg kg-1 or 0.9% saline for 15 days. On the sixteenth day, 3.5 mg kg-1 of rocuronium was administered to achieve complete neuromuscular blockade. Main outcome measures: The recovery time to a train-of-four ratio Results: There were no significant differences in the recovery time to train-of-four ratio to 0.9 among the groups (P = 0.531). The time to second twitch of train-of-four recovery that indicated the duration of rocuronium-induced neuromuscular blockade was significantly shorter in Group D than in Groups C and P (P = 0.001). Conclusion: As previously reported, resistance to rocuronium was observed in rats with chronic exposure to dexamethasone. However, the neuromuscular recovery time after sugammadex administration was not significantly different between groups.

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Effects of Coumarin Following Perinatal and Chronic Exposure in Sprague–Dawley Rats and CD-1 Mice

Fundamental and Applied Toxicology ◽

10.1006/faat.1996.0051 ◽

1996 ◽

Vol 30 (1) ◽

pp. 145-151 ◽

Cited By ~ 35

Author(s):

B Carlton

Keyword(s):

Chronic Exposure ◽

Sprague Dawley ◽

Sprague Dawley Rats

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The Excretion of Catecholamines in Rats During Acute and Chronic Exposure to Altitude

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y71-098 ◽

1971 ◽

Vol 49 (8) ◽

pp. 721-726 ◽

Cited By ~ 9

Author(s):

W. S. Myles ◽

A. J. Ducker

Keyword(s):

Body Weight ◽

Body Temperature ◽

Chronic Exposure ◽

Considerable Increase ◽

Temperature Acclimation ◽

Exposure Condition ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Acute And Chronic Exposure ◽

Increased Activity

The response of the sympathoadrenal medullary system in rats exposed to altitude has been assessed in terms of excretion of free noradrenaline (NA) and adrenaline (A) in the urine. Male Sprague–Dawley rats were either exposed acutely to simulated altitudes of 18 000 ft and 24 000 ft for 6 h or chronically to 18 000 ft for 5 weeks. Acutely exposed animals showed a considerable increase in the excretion of both catecholamines at 18 000 ft and 24 000 ft accompanied by a fall in body temperature. Acclimation to 18 000 ft by chronic exposure was achieved either by allowing the animals to reach the final altitude in stages during the 1st week, or by placing them directly at 18 000 ft. Body weight measurements confirmed that the second exposure condition was the more stressful. Although both groups showed an increase in NA excretion in the initial stages, only the second group exhibited an increase in A excretion. As the exposure continued, NA excretion returned towards sea level values. Preexposed animals maintained their body temperature at 18 000 ft and, when subsequently exposed to 24 000 ft for 6 h, did not excrete increased levels of NA or A. Increased activity of the sympathoadrenal medullary system appears to be involved only in the initial stages of acclimation to altitude.

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