Clofarabine for the treatment of adult acute lymphoid leukemia: the Group for Research on Adult Acute Lymphoblastic Leukemia intergroup

Abstract Objective: Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). Methods: Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. Results: From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. Conclusion: Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.

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Factors Associated with Pediatric Acute Leukemia. Medellín, Colombia. 2008-2011

International Journal of Cancer Research & Therapy ◽

10.33140/ijcrt/03/01/00005 ◽

2018 ◽

Vol 3 (1) ◽

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Acute Leukemia ◽

Metropolitan Area ◽

Lymphoblastic Leukemia ◽

Health Planning ◽

Daily Consumption ◽

Lymphoid Leukemia ◽

Acute Leukemias ◽

Factors Associated ◽

Acute Lymphoid Leukemia

Introduction: Acute leukemias have generated great interest in the world to be within the ten most common cancers, and children ranks first in malignancies. Objective: Analyze the demographic, genetic, environmental, pre and perinatal factors associated with acute lymphoblastic leukemia in pediatric acute leukemia group in Medellin during 2008 - 2011. Methods: Cross-sectional study in children under 15 years with leukemia acute in Medellin and the metropolitan area during 2008 -2011.Se implemented a logistic regression model to identify factors associated with acute lymphoblastic leukemia. Results: 80 patients were studied. Factors associated with multivariate analysis were acute lymphoid leukemia: Daily consumption of alcohol by the father (OR: 3.95; 95% CI 1.26 to 7.55) and that the child had been breastfed (OR: 0.036, 95% CI 0.002 to 0.83). Conclusions: The identification of risk and protective factors associated with acute lymphoid leukemia (ALL) in Medellin and its metropolitan area; they are a useful tool for health planning input.

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Faculty Opinions recommendation of Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1088852.541966 ◽

2007 ◽

Author(s):

Thomas Habermann

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Prognostic Factor ◽

Medical Research ◽

Research Council ◽

Medical Research Council ◽

Lymphoblastic Leukemia ◽

Eastern Cooperative Oncology Group ◽

Independent Prognostic Factor ◽

Oncology Group ◽

Adult Acute Lymphoblastic Leukemia

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The presence of TEL/AML1 rearrangement and cryptic deletion of the TEL gene in adult acute lymphoblastic leukemia (ALL)

Cancer Genetics and Cytogenetics ◽

10.1016/j.cancergencyto.2005.02.020 ◽

2005 ◽

Vol 162 (2) ◽

pp. 176-178 ◽

Cited By ~ 10

Author(s):

Dong Soon Lee ◽

Young Ree Kim ◽

Hyung Kyun Cho ◽

Chung Kee Lee ◽

Jee Hyung Lee ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Adult Acute Lymphoblastic Leukemia

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Treatment of adult acute lymphoblastic leukemia with intensive cyclical chemotherapy: a follow-up report

Blood ◽

10.1182/blood.v78.11.2814.2814 ◽

1991 ◽

Vol 78 (11) ◽

pp. 2814-2822 ◽

Cited By ~ 121

Author(s):

CA Linker ◽

LJ Levitt ◽

M O'Donnell ◽

SJ Forman ◽

CA Ries

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Disease Free Survival ◽

Remission Induction ◽

Cell Phenotype ◽

Free Survival ◽

Prognostic Features ◽

Adult Acute Lymphoblastic Leukemia ◽

Disease Free

Abstract We treated 109 patients with adult acute lymphoblastic leukemia (ALL) diagnosed by histochemical and immunologic techniques. Patients were excluded only for age greater than 50 years and Burkitt's leukemia. Treatment included a four-drug remission induction phase followed by alternating cycles of noncrossresistant chemotherapy and prolonged oral maintenance therapy. Eighty-eight percent of patients entered complete remission. With a median follow-up of 77 months (range, 48 to 111 months), 42% +/- 6% (SEM) of patients achieving remission are projected to remain disease-free at 5 years, and disease-free survival for all patients entered on study is 35% +/- 5%. Failure to achieve remission within the first 4 weeks of therapy and the presence of the Philadelphia chromosome are associated with a 100% risk of relapse. Remission patients with neither of these adverse features have a 48% +/- 6% probability of remaining in continuous remission for 5 years. Patients with T-cell phenotype have a favorable prognosis with 59% +/- 13% of patients achieving remission remaining disease-free compared with 31% +/- 7% of CALLA-positive patients. Intensive chemotherapy may produce prolonged disease-free survival in a sizable fraction of adults with ALL. Improved therapy is needed, especially for patients with adverse prognostic features.

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