Oral bioavailability enhancement of vinpocetine using self-microemulsifying drug delivery system containing long chain triglycerides: Preparation and in vitro/in vivo evaluation

2010 ◽  
Vol 27 (4) ◽  
pp. 97-107 ◽  
Author(s):  
Mona H. Aburahma ◽  
Hanan M. El-Laithy ◽  
Yassin El-Said Hamza
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
In Vivo Evaluation ◽  
Bioavailability Enhancement ◽  
Long Chain Triglycerides ◽  
Long Chain

scholarly journals Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 210 ◽  
Author(s):  
Jeand Baloch ◽  
Muhammad Farhan Sohail ◽  
Hafiz Shaib Sarwar ◽  
Maria Hassan Kiani ◽  
Gul Majid Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Loading ◽  
Antipsychotic Agent ◽  
In Vivo Evaluation ◽  
Promising Alternative ◽  
Long Chain Triglycerides ◽  
Long Chain

Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery. Chlorpromazine, an antipsychotic agent with poor aqueous solubility—with extensive first-pass metabolism—can be a suitable candidate for the development of SNEDDS. The current study was designed to develop triglyceride-based SNEDDS of chlorpromazine to achieve improved solubility, stability, and oral bioavailability. Materials and Methods: Fifteen SNEDDS formulations of each short, medium, and long chain, triglycerides were synthesized and characterized to achieve optimized formulation. The optimized formulation was characterized for several in vitro and in vivo parameters. Results: Particle size, zeta potential, and drug loading of the optimized SNEDDS (LCT14) were found to be 178 ± 16, −21.4, and 85.5%, respectively. Long chain triglyceride (LCT14) showed a 1.5-fold increased elimination half-life (p < 0.01), up to 6-fold increased oral bioavailability, and 1.7-fold decreased plasma clearance rate (p < 0.01) compared to a drug suspension. Conclusion: The findings suggest that SNEDDS based on long-chain triglycerides (LCT14) formulations seem to be a promising alternative for improving the oral bioavailability of chlorpromazine.

scholarly journals Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation

2020 ◽  
Vol Volume 15 ◽  
pp. 4847-4858
Author(s):  
Muhammad Hanif ◽  
Shahid Shah ◽  
Akhtar Rasul ◽  
Ghulam Abbas ◽  
Muhammad Zaman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
In Vivo Evaluation

Solid self-nanoemulsifying drug delivery system (S-SNEDDS) of darunavir for improved dissolution and oral bioavailability: In vitro and in vivo evaluation

2015 ◽  
Vol 74 ◽  
pp. 1-10 ◽  
Author(s):  
Spandana Inugala ◽  
Basanth Babu Eedara ◽  
Sharath Sunkavalli ◽  
Rajeshri Dhurke ◽  
Prabhakar Kandadi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
In Vivo Evaluation
Sign in / Sign up

Export Citation Format

Share Document