scholarly journals Galantamine-loaded solid–lipid nanoparticles for enhanced brain delivery: preparation, characterization, in vitro and in vivo evaluations

Drug Delivery ◽  
2015 ◽  
Vol 23 (4) ◽  
pp. 1434-1443 ◽  
Author(s):  
Shubham Misra ◽  
Kanwaljit Chopra ◽  
V. R. Sinha ◽  
Bikash Medhi
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Delivery ◽  
Solid Lipid

Brain delivery of camptothecin by means of solid lipid nanoparticles: Formulation design, in vitro and in vivo studies

2012 ◽  
Vol 439 (1-2) ◽  
pp. 49-62 ◽  
Author(s):  
Susana Martins ◽  
Ingunn Tho ◽  
Isolde Reimold ◽  
Gert Fricker ◽  
Eliana Souto ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
Formulation Design ◽  
Solid Lipid

scholarly journals Improved brain delivery of pueraria flavones via intranasal administration of borneol-modified solid lipid nanoparticles

Nanomedicine ◽  
2019 ◽  
Vol 14 (16) ◽  
pp. 2105-2119 ◽  
Author(s):  
Liping Wang ◽  
Xiao Zhao ◽  
Junfeng Du ◽  
Mei Liu ◽  
Jianfang Feng ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Intranasal Administration ◽  
Brain Area ◽  
Area Under The Curve ◽  
Lipid Nanoparticles ◽  
Brain Delivery ◽  
Solid Lipid ◽  
Physical And Chemical

Aim: To improve the drug delivery to the brain with borneol (Bo)-modified solid lipid nanoparticles (SLNs) of pueraria flavones (PTF) via intranasal administration. Materials & methods: PTF-loaded SLNs were modified with Bo by physical and chemical methods to synthesize PTF-Bo-SA-SLNs and PTF-Bo-SLNs. The prepared SLNs were characterized and their brain delivery effects were evaluated in vitro and in vivo. Results: There was a more pronounced accumulation of PTF-Bo-SA-SLNs in Caco-2 cells. Following intranasal administration, more coumarin-6 was found in the rat brain carried by Bo-SA-SLNs. Brain area under the curve and Cmax of PTF-Bo-SA-SLN were 7.31- and 7.29-times higher than those of PTF-SLN, respectively. Conclusion: PTF-Bo-SA-SLNs are a promising therapeutic carrier for brain disease after intranasal administration.

Solid Lipid Nanoparticles (SLNs) Gels for Topical Delivery of Aceclofenac in vitro and in vivo Evaluation

2013 ◽  
Vol 10 (6) ◽  
pp. 656-666 ◽  
Author(s):  
Sandipan Dasgupta ◽  
Surajit Ghosh ◽  
Subhabrata Ray ◽  
Bhaskar Mazumder
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Topical Delivery ◽  
Lipid Nanoparticles ◽  
In Vivo Evaluation ◽  
Solid Lipid

Transdermal Delivery of Curcumin-Loaded Solid Lipid Nanoparticles as Microneedle Patch: an In Vitro and In Vivo Study

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Ankitha Prabhu ◽  
Jobin Jose ◽  
Lalit Kumar ◽  
S Salwa ◽  
M Vijay Kumar ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Study ◽  
Solid Lipid ◽  
Microneedle Patch
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