Methods for a Conprkhensive Characterization of Nicrocapsules Based on Polyelectrolyte Complexes

1993 ◽  
Vol 21 (3) ◽  
pp. 399-405 ◽  
Author(s):  
H. Dautzenberg ◽  
G. Holzapfel ◽  
B. Lukanoff
Keyword(s):  
Polyelectrolyte Complexes

Preparation and characterization of pH-sensitive microparticles based on polyelectrolyte complexes for antibiotic delivery

2014 ◽  
Vol 55 (5) ◽  
pp. 981-987 ◽  
Author(s):  
L. Agüero ◽  
D. Zaldivar ◽  
L. Peña ◽  
Y. Solís ◽  
J.A. Ramón ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Polyelectrolyte Complexes ◽  
Antibiotic Delivery

scholarly journals Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir

Pharmaceutics ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 20 ◽  
Author(s):  
Raúl Cazorla-Luna ◽  
Fernando Notario-Pérez ◽  
Araceli Martín-Illana ◽  
Roberto Ruiz-Caro ◽  
Aitana Tamayo ◽  
...  
Keyword(s):  
Sexual Transmission ◽  
Microstructural Characterization ◽  
Vaginal Fluid ◽  
Vaginal Mucosa ◽  
Vaginal Microbicides ◽  
Polyelectrolyte Complexes ◽  
Antiretroviral Drug ◽  
Sexual Transmission Of Hiv ◽  
Self Protection

Vaginal microbicides have the potential to give women at high risk of contracting HIV the option of self-protection by preventing the sexual transmission of the virus. In this paper, mucoadhesive vaginal tablets based on chitosan, alone and in combination with pectin and locust bean gum, were developed for the sustained release of tenofovir (an antiretroviral drug). The formulations were placed in simulant vaginal fluid (SVF) to swell, and Hg porosity and SEM microscopy were used for the microstructural characterization of the swelling witnesses. The results show that the association of pectin and chitosan generated polyelectrolyte complexes and produced a robust system able to maintain its structure during the swelling process, when small pores are formed. Drug release and bovine vaginal mucoadhesion studies were performed in SVF showing that tenofovir-controlled dissolution profiles and adhesion to the mucosa were conditioned by the swelling processes of the polymer/s in each formulation. Tablets based on chitosan/pectin have the most homogeneous tenofovir dissolution profiles and last up to 96 h, remaining attached to the vaginal mucosa for the same period. These formulations can therefore be considered a good option for the self-protection of women from the sexual transmission of HIV.

scholarly journals Preparation and Characterization of Polyelectrolyte Complexes of Hibiscus esculentus (Okra) Gum and Chitosan

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Vivekjot Brar ◽  
Gurpreet Kaur
Keyword(s):  
Zeta Potential ◽  
Maximum Yield ◽  
Weight Ratio ◽  
Sem Analysis ◽  
Ionic Gelation ◽  
Complete Conversion ◽  
Polyelectrolyte Complexes ◽  
Hibiscus Esculentus ◽  
Okra Gum

Polyelectrolyte complexes (PECs) of Okra gum (OKG) extracted from fruits of Hibiscus esculentus (Malvaceae) and chitosan (CH) were prepared using ionic gelation technique. The PECs were insoluble and maximum yield was obtained at weight ratio of 7 : 3. The supernatant obtained after extracting PECs was clearly representing complete conversion of polysaccharides into PECs. Complexation was also evaluated by measuring the viscosity of supernatant after precipitation of PECs. The dried PECs were characterized using FTIR, DSC, zeta potential, water uptake, and SEM studies. Thermal analysis of PECs prepared at all ratios (10 : 90, 20 : 80, 30 : 70, 40 : 60, 50 : 50, 60 : 40, 70 : 30, 80 : 20, and 90 : 10; OKG : CH) depicted an endothermic peak at approximately 240°C representing cleavage of electrostatic bond between OKG and CH. The optimized ratio (7 : 3) exhibited a zeta potential of −0.434 mV and displayed a porous structure in SEM analysis. These OKG-CH PECs can be further employed as promising carrier for drug delivery.

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