Modulatory actions ofo-coumaric acid on carcinogen-activating cytochrome P450 isozymes and the potential for drug interactions in human hepatocarcinoma cells

2015 ◽  
Vol 53 (9) ◽  
pp. 1391-1398 ◽  
Author(s):  
Alaattin Sen ◽  
Gulsum Terzioglu ◽  
Pelin Atmaca ◽  
Gurbet Celik ◽  
Ozden Ozgun ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Coumaric Acid ◽  
Hepatocarcinoma Cells ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes ◽  
Human Hepatocarcinoma Cells

Antibodies as Probes of Cytochrome P450 Isozymes

1986 ◽  
pp. 95-106 ◽  
Author(s):  
Paul E. Thomas ◽  
Linda M. Reik ◽  
Sarah L. Maines ◽  
Stelvio Bandiera ◽  
Dene E. Ryan ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes

Efavirenz-induced neurological symptoms in rare homozygote CYP2B6 *2/*2 (C64T)

2007 ◽  
Vol 18 (8) ◽  
pp. 575-576 ◽  
Author(s):  
Osamu Usami ◽  
Yugo Ashino ◽  
Yuichi Komaki ◽  
Masafumi Tomaki ◽  
Toshiya Irokawa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytochrome P450 ◽  
Plasma Concentrations ◽  
Highly Active ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes ◽  
Hiv 1 ◽  
Rare Homozygote ◽  
Hepatic Cytochrome

Some of the HIV-1-infected patients who were given highly active anti-retroviral therapy (HAART) including efavirenz (EFV) presented adverse central nervous system (CNS) symptoms such as fatigue and insomnia. The incidence of adverse CNS symptoms is associated with hepatic cytochrome P450 isozymes (CYP2B6) polymorphisms. For example, CYP2B6 *6 (G516T and A785G) and *7 (G516T, A785G and C1459T) prolonged the EFV half-life despite discontinuation of EFV. CYP2B6 *2/*2 (C64T) is extremely rare and there have been no data describing the EFV plasma concentrations in C64T homozygous patients, who developed adverse CNS symptoms. C64T homozygous possibly has some catalytic defects.

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