Prepregnancy body mass index is an independent risk factor for gestational hypertension, gestational diabetes, preterm labor, and small- and large-for-gestational-age infants

Objective: To evaluate the impact of obesity on maternal and neonatal outcome. Study Design: Comparative cross sectional study. Place and Duration of Study: Department of Gynaecology and Obstetrics, Pakistan Naval Ship, Shifa HospitalKarachi, from Nov 2016 to Oct 2017. Methodology: All singleton pregnant women of normal prepregnancy body mass index (BMI) and obese women having ≥30 body mass index, delivering newborn at 28-42 weeks of gestation were included. Comparison of antenatal complications and neonatal outcomes was done among both groups. Results: Obese women significantly developed gestational hypertension (OR=7.4 95% CI, 4.84-11.4), preeclampsia (OR=2.22 95% CI, 1.36-3.6), gestational diabetes mellitus (OR=5.2; 95% CI, 3.57-7.58), labor induction (OR= 2.79 95% CI, 2.03-3.84), failed induction of labor (OR = 5.3 95% CI, 8.05-29.38), cesarean delivery (OR=1.89 95% CI, 1.41-2.5), large for gestational age newborn (OR=3.97 95% CI, 2.87-5.50). But there was no statistically significant difference in small for gestational age newborn (OR=0.91 95% CI, 0.42-1.98), new born with APGAR score ≤7 after 5 min after delivery (OR=2.168 95% CI, 0.97-4.82) among obese and normal weight pregnant women. Conclusion: There is increased risk of gestational hypertension, preeclampsia, gestational diabetes, failed induction of labor, dystocia, cesarean delivery and large for gestational age newborns in obese women.Keywords: , , , , ,

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Changes in prepregnancy body mass index between the first and second pregnancies and risk of large-for-gestational-age birth

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2006.12.036 ◽

2007 ◽

Vol 196 (6) ◽

pp. 530.e1-530.e8 ◽

Cited By ~ 41

Author(s):

Darios Getahun ◽

Cande V. Ananth ◽

Morgan R. Peltier ◽

Hamisu M. Salihu ◽

William E. Scorza

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Gestational Age ◽

Large For Gestational Age ◽

Prepregnancy Body Mass Index

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269: Is the risk association between high body mass index and large for gestational age infants magnified by pre-gestational diabetes?

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2009.10.284 ◽

2009 ◽

Vol 201 (6) ◽

pp. S111

Author(s):

Katherine Goetzinger ◽

Alison Cahill ◽

George Macones ◽

Anthony Odibo

Keyword(s):

Body Mass Index ◽

Gestational Diabetes ◽

Body Mass ◽

Gestational Age ◽

High Body Mass Index ◽

Large For Gestational Age ◽

High Body ◽

Risk Association

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Maternal Body Mass Index and Ethnicity in Relation to The Adverse Outcomes of Large for Gestational Age and Gestational Diabetes Mellitus in a Retrospective Cohort of Australian Pregnant Women.

10.21203/rs.3.rs-152021/v1 ◽

2021 ◽

Author(s):

Catherine Knight-Agarwal ◽

Jani Rati ◽

Meisa Al-Foraih ◽

Dionne Eckley ◽

Carrie Ka Wai Lui ◽

...

Keyword(s):

Diabetes Mellitus ◽

Body Mass Index ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Body Mass ◽

Gestational Age ◽

Retrospective Cohort ◽

Adverse Outcomes ◽

Large For Gestational Age ◽

Maternal Body Mass Index

Abstract Background: The prevalence of maternal overweight and obesity has been increasing. This research explored the association between maternal body mass index and ethnicity in relation to the adverse outcomes of large for gestational age and gestational diabetes mellitus. Method: A retrospective cohort study was undertaken with 27 814 Australian women of various ethnicities, who gave birth to a singleton infant between 2008 and 2017. Variables were examined using logistic regression. Results: A significantly higher proportion of large for gestational age infants were born to overweight and obese women compared to those who were classified as underweight and healthy weight. Asian-born women with a body mass index of ≥ 40kg/m2 had an adjusted odds ratio of 9.926 (3.859 - 25.535) for birthing a large for gestational age infant whereas Australian-born women had an adjusted odds ratio of 2.661 (2.256 - 3.139) for the same outcome. Women born in Australia were at high risk of birthing a large for gestational age infant in the presence of insulin controlled gestational diabetes mellitus, but this risk was not significant for those with the diet-controlled type. Asian-born women did not present an elevated risk of birthing a large for gestational infant, in either the diet controlled, or insulin controlled gestational diabetes mellitus groups. Conclusion: Large for gestational age and gestational diabetes mellitus are adverse pregnancy outcomes that can lead to significant maternal and neonatal morbidity. Women who are overweight or obese, and considering a pregnancy, are encouraged to seek culturally appropriate nutrition and weight management advice during the periconception period.

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Maternal body mass index and country of birth in relation to the adverse outcomes of large for gestational age and gestational diabetes mellitus in a retrospective cohort of Australian pregnant women

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-04125-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Catherine R. Knight-Agarwal ◽

Rati Jani ◽

Meisa Al Foraih ◽

Dionne Eckley ◽

Carrie Ka Wai Lui ◽

...

Keyword(s):

Diabetes Mellitus ◽

Body Mass Index ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Body Mass ◽

Gestational Age ◽

Adverse Outcomes ◽

Large For Gestational Age ◽

Maternal Body Mass Index ◽

Country Of Birth

Abstract Background The prevalence of gestational diabetes mellitus in Australia has been rising in line with the increased incidence of maternal overweight and obesity. Women with gestational diabetes mellitus, high body mass index or both are at an elevated risk of birthing a large for gestational age infant. The aim was to explore the relationship between country of birth, maternal body mass index with large for gestational age, and gestational diabetes mellitus. In addition to provide additional information for clinicians when making a risk assessment for large for gestational age babies. Method A retrospective cohort study of 27,814 women residing in Australia but born in other countries, who gave birth to a singleton infant between 2008 and 2017 was undertaken. Logistic regression analysis was used to examine the association between the aforementioned variables. Results A significantly higher proportion of large for gestational age infants was born to overweight and obese women compared to those who were classified as underweight and healthy weight. Asian-born women residing in Australia, with a body mass index of ≥40 kg/m2, had an adjusted odds ratio of 9.926 (3.859–25.535) for birthing a large for gestational age infant. Conversely, Australian-born women with a body mass index of ≥40 kg/m2 had an adjusted odds ratio of 2.661 (2.256–3.139) for the same outcome. Women born in Australia were at high risk of birthing a large for gestational age infant in the presence of insulin-requiring gestational diabetes mellitus, but this risk was not significant for those with the diet-controlled type. Asian-born women did not present an elevated risk of birthing a large for gestational age infant, in either the diet controlled, or insulin requiring gestational diabetes mellitus groups. Conclusions Women who are overweight or obese, and considering a pregnancy, are encouraged to seek culturally appropriate nutrition and weight management advice during the periconception period to reduce their risk of adverse outcomes.

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