The Relationship between Particulate Matter (PM10) and Hospitalizations and Mortality Of Chronic Obstructive Pulmonary Disease: A Meta-Analysis

2013 ◽  
Vol 10 (3) ◽  
pp. 307-315 ◽  
Author(s):  
Ruixia Zhu ◽  
Yahong Chen ◽  
Shaowei Wu ◽  
Furong Deng ◽  
Yue Liu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Particulate Matter ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Relationship

scholarly journals Investigation Regarding the Correlation between Particulate Matter 2.5 Air Pollution and Mortality Rates due to Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 6 (1) ◽  
pp. 53-59
Author(s):  
Ekta Dhanoa
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Air Pollution ◽  
Particulate Matter ◽  
Pulmonary Disease ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Chronic Obstructive ◽  
Pearson Correlation Coefficient ◽  
Obstructive Pulmonary Disease ◽  
The Relationship

In 2015, 3.2 million people died due to Chronic Obstructive Pulmonary Disease (COPD), worldwide. In fact, survival rates for those living with severe COPD are lower than for those with cancer. The one known contributor to this disease is air pollution, and with its rising levels every year, it is necessary to determine the exact correlation between air pollution and COPD. Data was gathered for a selection of 20 countries from the World Bank Database and Health Data Database. This data was graphed and analyzed using the Pearson correlation coefficient, which is a statistical test that measures the relationship between 2 variables. When calculated, the Pearson correlation coefficient was 0.756, determining that there is a significant relationship between air pollution and COPD. Through the investigation, it is concluded that there is a positive correlation between PM2.5 air pollution and mortality rate due to COPD. PM2.5 is a component of air pollution defined as the amount of atmospheric particulate matter with a diameter less than 2.5 micrometers. Due to its small physical nature, PM2.5 can easily infiltrate the lungs, causing infections in the respiratory organs. They can reach the bronchi and even the alveoli, causing inflammation which ultimately results in COPD and premature deaths. Therefore, this research will aim to investigate the relationship between PM2.5 air pollution and COPD, allowing for a better understanding of these variables.

scholarly journals Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sang Wook Kang ◽  
Su Kang Kim ◽  
Joo-Ho Chung ◽  
Hee-Jae Jung ◽  
Kwan-Il Kim ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Asian Population ◽  
Caucasian Population ◽  
Chronic Obstructive ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
Obstructive Pulmonary Disease ◽  
The Relationship

The relationship between polymorphism of the angiotensin I converting enzyme (ACE) gene and chronic obstructive pulmonary disease (COPD) has been examined in many previous studies. However, their results were controversial. Therefore, we performed a meta-analysis to evaluate the relationship between theACEgene and the risk of COPD. Fourteen case-control studies were included in this meta-analysis. The pooledpvalue, odds ratio (OR), and 95% confidence interval (95% CI) were used to investigate the strength of the association. The meta-analysis was performed using comprehensive meta-analysis software. Our meta-analysis results revealed that ACE polymorphisms were not related to the risk of COPD (p>0.05in each model). In further analyses based on ethnicity, we observed an association between insertion/deletion polymorphism of theACEgene and risk of COPD in the Asian population (codominant 2, OR = 3.126, 95% CI = 1.919–5.093,p<0.001; recessive, OR = 3.326, 95% CI = 2.190–5.050,p<0.001) but not in the Caucasian population (p>0.05in each model). In conclusion, the present meta-analysis indicated that the insertion/deletion polymorphism of theACEgene may be associated with susceptibility to COPD in the Asian population but not in the Caucasian population. However, the results of the present meta-analysis need to be confirmed in a larger sample.

scholarly journals Safety and efficacy of inpatient pulmonary rehabilitation for patients hospitalised with an acute exacerbation of chronic obstructive pulmonary disease: a systematic review protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e043377
Author(s):  
Kai Zhu ◽  
Jagdeep Gill ◽  
Ashley Kirkham ◽  
Joel Chen ◽  
Amy Ellis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Pulmonary Rehabilitation ◽  
Meta Analysis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Safety And Efficacy

IntroductionPulmonary rehabilitation (PR) following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) reduces the risk of hospital admissions, and improves physical function and health-related quality of life. However, the safety and efficacy of in-hospital PR during the most acute phase of an AECOPD is not well established. This paper describes the protocol for a systematic review with meta-analysis to determine the safety and efficacy of inpatient acute care PR during the hospitalisation phase.Methods and analysisMedical literature databases and registries MEDLINE, EMBASE, Physiotherapy Evidence Database, Cumulative Index to Nursing and Allied Health Literature, Canadian Agency for Drugs and Technologies in Health, CENTRAL, Allied and Complementary Medicine Database, WHO trials portal and ClinicalTrials.gov will be searched for articles from inception to June 2021 using a prespecified search strategy. We will identify randomised controlled trials that have a comparison of in-hospital PR with usual care. PR programmes had to commence during the hospitalisation and include a minimum of two sessions. Title and abstract followed by full-text screening will be conducted independently by two reviewers. A meta-analysis will be performed if there is sufficient homogeneity across selected studies or groups of studies. The Population, Intervention, Comparator, Outcomes and Study characteristics framework will be used to standardise the data collection process. The quality of the cumulative evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations framework.Ethics and disseminationAECOPD results in physical limitations which are amenable to PR. This review will assess the safety and efficacy of in-hospital PR for AECOPD. The results will be presented in a peer-reviewed publication and at research conferences. Ethical review is not required for this study.

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